Fgd1
Gene Detail

Symbol Name ID

Fgd1 FYVE, RhoGEF and PH domain containing 1 MGI:104566

Synonyms

faciogenital dysplasia, ZFYVE3

Feature Type

protein coding gene

Genetic Map

Chromosome X

68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:151046150-151089521 bp, + strand From VEGA annotation of GRCm38   43372 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Fgd1 ± 2 cM)

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd1

Human ortholog

FGD1 FYVE, RhoGEF and PH domain containing 1 NCBI Gene ID 2245
Human Synonyms: AAS, FGDY, MRXS16, ZFYVE3
Human ChrX:54471887-54522599 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human FGD1 (1)

Alleles and phenotypes

All alleles(77) : Gene trapped(77)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	actin cytoskeleton organization, cytoskeleton organization, ...
Component	cell projection, cytoplasm, ...
Function	guanyl-nucleotide exchange factor activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (129)    Tissues (58)    Images (24)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	75
Northern blot	8
RT-PCR	46

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019292 (Evidence)
Ensembl Gene Model	ENSMUSG00000025265 (Evidence)
Entrez Gene	14163 (Evidence)
Consensus CDS Project	CCDS30467.1
International Mouse Knockout Project Status	Fgd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019292	VEGA Gene Model | MGI Sequence Detail	43372	C57BL/6J
transcript	OTTMUST00000046115	VEGA | MGI Sequence Detail	4001	Not Applicable
polypeptide	OTTMUSP00000020818	VEGA | MGI Sequence Detail	960	Not Applicable

All sequences(33) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000007473	FYVE, RhoGEF and PH domain-containing protein 1

References

(Earliest) J:26633 Pasteris NG, et al., Cloning and regional localization of the mouse faciogenital dysplasia (Fgd1) gene. Mamm Genome. 1995 Sep;6(9):658-61
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Other accession IDs

MGD-MRK-26000