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Fgd1
Gene Detail
 Symbol
Name
ID
Fgd1
FYVE, RhoGEF and PH domain containing 1
MGI:104566
Synonyms faciogenital dysplasia, ZFYVE3
Feature Type protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:151046150-151089521 bp, + strand
From VEGA annotation of GRCm38

  43372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd1

Human
homologs
Human Homolog FGD1, FYVE, RhoGEF and PH domain containing 1
NCBI Gene ID 2245
neXtProt AC  NX_P98174
Human Synonyms  AAS, FGDY, MRXS16, ZFYVE3
Human Chr (Location)  Xp11.21; chrX:54445454-54496166 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(77)
Incidental mutations (data from APF )
Interactions
Fgd1 interacts with 98 markers (Mir17, Mir19a, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process actin cytoskeleton organization, cytoskeleton organization, ...
Component cell projection, cytoplasm, ...
Function guanyl-nucleotide exchange factor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (129)    Tissues (58)    Images (24)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 75
Northern blot 8
RT-PCR 46
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019292 (Evidence)
Ensembl Gene ModelENSMUSG00000025265 (Evidence)
Entrez Gene14163 (Evidence)
Consensus CDS ProjectCCDS30467.1
International Mouse Knockout Project StatusFgd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019292 VEGA Gene Model | MGI Sequence Detail 43372 C57BL/6J ±  kb
transcript OTTMUST00000046115 VEGA | MGI Sequence Detail 4001 Not Applicable 
polypeptide OTTMUSP00000020818 VEGA | MGI Sequence Detail 960 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000007473 FYVE, RhoGEF and PH domain-containing protein 1
References (Earliest) J:26633 Pasteris NG, et al., Cloning and regional localization of the mouse faciogenital dysplasia (Fgd1) gene. Mamm Genome. 1995 Sep;6(9):658-61
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGD-MRK-26000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory