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Napa
Gene Detail
Symbol

Name
ID
Napa
N-ethylmaleimide sensitive fusion protein attachment protein alpha
MGI:104563
Synonyms
1500039N14Rik, a-SNAP, hyh, RA81, SNAPA, SNARE
Feature Type
protein coding gene
Genetic Map
Chromosome 7
8.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:16098458-16117975 bp, + strand
From VEGA annotation of GRCm38

  19518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2839  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: soluble NSF attachment protein
Gene Tree: Napa

Human
homologs
Human Homolog NAPA, N-ethylmaleimide-sensitive factor attachment protein, alpha
NCBI Gene ID 8775
neXtProt AC  NX_P54920
Human Synonyms  SNAPA
Human Chr (Location)  19q13.33; chr19:47487634-47515258 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
The homozygous null mutation is embryonic lethal while partial loss of function homozygous mutants develop hydrocephalus and die postnatally. These mutants also display central nervous system abnormalities and impaired motor capabilities.
 
Interactions
Napa interacts with 185 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process apical protein localization, brain development, ...
Component cell, extracellular vesicular exosome, ...
Function protein binding, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (30)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Western blot 2
cDNA source data(238)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(239) cDNA(239)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023922 (Evidence)
Ensembl Gene ModelENSMUSG00000006024 (Evidence)
Entrez Gene108124 (Evidence)
UniGene104540
DFCITC1573250
DoTSDT.101394424, DT.536141, DT.97338435
NIA Mouse Gene IndexU007700
Consensus CDS ProjectCCDS20843.1
International Mouse Knockout Project StatusNapa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023922 VEGA Gene Model | MGI Sequence Detail 19518 C57BL/6J ±  kb
transcript OTTMUST00000058448 VEGA | MGI Sequence Detail 2517 Not Applicable 
polypeptide OTTMUSP00000028316 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000744 NSF attachment protein
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000010981 alpha-soluble NSF attachment protein
References
(Earliest) J:14015 Lane PW, Hydrocephaly with hop gait (hyh). Mouse News Lett. 1985;73:18
(Latest) J:167753 Burgalossi A, et al., SNARE protein recycling by alphaSNAP and betaSNAP supports synaptic vesicle priming. Neuron. 2010 Nov 4;68(3):473-87
All references(56)
Other
accession IDs
MGD-MRK-11037, MGD-MRK-25997, MGI:1328319, MGI:1914252, MGI:2142218, MGI:96302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory