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Napb
Gene Detail
Symbol

Name
ID
Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
MGI:104562
Synonyms
Brp14, b-SNAP, E161, I47, SNARE
Feature Type
protein coding gene
Genetic Map
Chromosome 2
73.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:148693985-148732467 bp, - strand
From VEGA annotation of GRCm38

  38483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5332  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: soluble NSF attachment protein
Gene Tree: Napb

Human
homologs
Human Homolog NAPB, N-ethylmaleimide-sensitive factor attachment protein, beta
NCBI Gene ID 63908
neXtProt AC  NX_Q9H115
Human Synonyms  SNAPB, SNAP-BETA
Human Chr (Location)  20p12.3-p11.21; chr20:23374519-23421519 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit seizures, ataxia, abnormal synaptic vesicle priming, and premature death.
 
Interactions
Napb interacts with 411 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process intracellular protein transport, membrane fusion, ...
Component extracellular vesicular exosome, membrane, ...
Function protein binding, soluble NSF attachment protein activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (128)    Tissues (34)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000015716 (Evidence)
Ensembl Gene ModelENSMUSG00000027438 (Evidence)
Entrez Gene17957 (Evidence)
DFCITC1659128, TC1592357, TC1577878, TC1695921
DoTSDT.94313323, DT.55245822, DT.94383879, DT.94393348
NIA Mouse Gene IndexU023466
Consensus CDS ProjectCCDS16842.1
International Mouse Knockout Project StatusNapb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015716 VEGA Gene Model | MGI Sequence Detail 38483 C57BL/6J ±  kb
transcript OTTMUST00000037337 VEGA | MGI Sequence Detail 4412 Not Applicable 
polypeptide OTTMUSP00000016726 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000744 NSF attachment protein
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000010982 beta-soluble NSF attachment protein
References
(Earliest) J:18876 Puschel AW, et al., The N-ethylmaleimide-sensitive fusion protein (NSF) is preferentially expressed in the nervous system. FEBS Lett. 1994 Jun 20;347(1):55-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGD-MRK-25996, MGI:1930655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory