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Nsf
Gene Detail
Symbol

Name
ID
Nsf
N-ethylmaleimide sensitive fusion protein
MGI:104560
Synonyms
N-ethylmaleimide sensitive factor, SKD2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
67.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:103821782-103954056 bp, - strand
From VEGA annotation of GRCm38

  132275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NSF
Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Nsf

Human
homologs
NSF, N-ethylmaleimide-sensitive factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4905
neXtProt AC: NX_P46459

Human Synonyms: SKD2

Human Chr (Location): 17q21; chr17:46590669-46757464 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(138) : Gene trapped(135) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Nsf interacts with 234 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process Golgi to plasma membrane protein transport, Golgi vesicle docking, ...
Component cytoplasm, dendritic shaft, ...
Function ATPase activity, ATPase activity, coupled, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (194)    Tissues (133)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 184
Western blot 4
RT-PCR 6
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase nsf ; ZFIN nsfa, nsfb    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000003022 (Evidence)
Ensembl Gene Model ENSMUSG00000034187 (Evidence)
Entrez Gene 18195 (Evidence)
DFCI TC1573896, TC1660834, TC1608602
DoTS DT.97415200, DT.97415197, DT.91576973, DT.91437239, DT.101318535
NIA Mouse Gene Index U033515
EC 3.6.4.6
Consensus CDS Project CCDS25524.1
International Mouse Phenotyping Consortium Status Nsf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003022 VEGA Gene Model | MGI Sequence Detail 132275 C57BL/6J ±  kb
transcript OTTMUST00000006200 VEGA | MGI Sequence Detail 3766 Not Applicable 
polypeptide OTTMUSP00000002926 VEGA | MGI Sequence Detail 744 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(761 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR009010 Aspartate decarboxylase-like domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR004201 CDC48, domain 2
InterPro IPR003338 CDC48, N-terminal subdomain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011443 vesicle-fusing ATPase
References
(Earliest) J:18876 Puschel AW, et al., The N-ethylmaleimide-sensitive fusion protein (NSF) is preferentially expressed in the nervous system. FEBS Lett. 1994 Jun 20;347(1):55-8
(Latest) J:209576 Piccoli G, et al., Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. Mol Cell Biol. 2014 Jun 15;34(12):2147-2161
All references(63)
Other
accession IDs
MGD-MRK-25994, MGI:2144115, MGI:2144400, MGI:2144446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory