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Nsf
Gene Detail
 Symbol
Name
ID
Nsf
N-ethylmaleimide sensitive fusion protein
MGI:104560
Synonyms N-ethylmaleimide sensitive factor, SKD2
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:103821782-103954056 bp, - strand
From VEGA annotation of GRCm38

  132275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Nsf

Human
homologs
Human Homolog NSF, N-ethylmaleimide-sensitive factor
NCBI Gene ID 4905
neXtProt AC  NX_P46459
Human Synonyms  SKD2
Human Chr (Location)  17q21; chr17:46590669-46757464 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(138) : Gene trapped(135) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nsf interacts with 234 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process ATP catabolic process, positive regulation of receptor recycling, ...
Component cytoplasm, dendritic shaft, ...
Function ATPase activity, ATPase activity, coupled, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (194)    Tissues (133)    Images (44)
Theiler Stages: 17, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 184
Western blot 4
RT-PCR 6
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000003022 (Evidence)
Ensembl Gene ModelENSMUSG00000034187 (Evidence)
Entrez Gene18195 (Evidence)
DFCITC1573896, TC1608602, TC1660834
DoTSDT.101318535, DT.91437239, DT.91576973, DT.97415197, DT.97415200
NIA Mouse Gene IndexU033515
EC3.6.4.6
Consensus CDS ProjectCCDS25524.1
International Mouse Knockout Project StatusNsf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003022 VEGA Gene Model | MGI Sequence Detail 132275 C57BL/6J ±  kb
transcript OTTMUST00000006200 VEGA | MGI Sequence Detail 3766 Not Applicable 
polypeptide OTTMUSP00000002926 VEGA | MGI Sequence Detail 744 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(761 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR009010 Aspartate decarboxylase-like domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR004201 CDC48, domain 2
InterPro IPR003338 CDC48, N-terminal subdomain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011443 vesicle-fusing ATPase
References (Earliest) J:18876 Puschel AW, et al., The N-ethylmaleimide-sensitive fusion protein (NSF) is preferentially expressed in the nervous system. FEBS Lett. 1994 Jun 20;347(1):55-8
(Latest) J:209576 Piccoli G, et al., Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. Mol Cell Biol. 2014 Jun 15;34(12):2147-2161
All references(61)
Other
accession IDs
MGD-MRK-25994, MGI:2144115, MGI:2144400, MGI:2144446

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory