Nsf
Gene Detail

Symbol Name ID

Nsf N-ethylmaleimide sensitive fusion protein MGI:104560

Synonyms

N-ethylmaleimide sensitive factor, SKD2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:103821782-103954056 bp, - strand From VEGA annotation of GRCm38   132275 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4502  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Nsf

Human homologs

Human Homolog		NSF, N-ethylmaleimide-sensitive factor
NCBI Gene ID		4905
neXtProt AC		NX_P46459
Human Synonyms		SKD2
Human Chr (Location)		17q21; chr17:44668035-44834830 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(138) : Targeted(3) Gene trapped(135)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	ATP catabolic process, positive regulation of receptor recycling, ...
Component	cytoplasm, dendritic shaft, ...
Function	ATPase activity, ATPase activity, coupled, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (194)    Tissues (133)    Images (44)
Theiler Stages: 17, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	184
Western blot	4
RT-PCR	6

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000003022 (Evidence)
Ensembl Gene Model	ENSMUSG00000034187 (Evidence)
Entrez Gene	18195 (Evidence)
DFCI	TC1573896, TC1608602, TC1660834
DoTS	DT.101318535, DT.91437239, DT.91576973, DT.97415197, DT.97415200
NIA Mouse Gene Index	U033515
EC	3.6.4.6
Consensus CDS Project	CCDS25524.1
International Mouse Knockout Project Status	Nsf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003022	VEGA Gene Model | MGI Sequence Detail	132275	C57BL/6J
transcript	OTTMUST00000006200	VEGA | MGI Sequence Detail	3766	Not Applicable
polypeptide	OTTMUSP00000002926	VEGA | MGI Sequence Detail	744	Not Applicable

All sequences(74) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(612 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR009010	Aspartate decarboxylase-like domain
InterPro	IPR003960	ATPase, AAA-type, conserved site
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR004201	CDC48, domain 2
InterPro	IPR003338	CDC48, N-terminal subdomain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000011443	vesicle-fusing ATPase

References

(Earliest) J:18876 Puschel AW, et al., The N-ethylmaleimide-sensitive fusion protein (NSF) is preferentially expressed in the nervous system. FEBS Lett. 1994 Jun 20;347(1):55-8
(Latest) J:169453 Piccoli G, et al., LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci. 2011 Feb 9;31(6):2225-37
All references(59)

Other accession IDs

MGD-MRK-25994, MGI:2144115, MGI:2144400, MGI:2144446