Rcn1 MGI Mouse Gene Detail - MGI:104559

Symbol

Rcn1
Name

reticulocalbin 1
Synonyms

Rcn

Feature Type

protein coding gene
IDs

MGI:104559
NCBI Gene: 19672
Gene Overview

MyGene.info: RCN1
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:105386291-105399319 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 55.18 cM
Mapping Data

7 experiments

SNPs within 2kb

138 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104559	protein coding gene	Chr2:105385948-105399319 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026229	protein coding gene	Chr2:107545719-107558747 (-)
A/J	MGP_AJ_G0026190	protein coding gene	Chr2:103061702-103074898 (-)
AKR/J	MGP_AKRJ_G0026170	protein coding gene	Chr2:105871593-105884782 (-)
BALB/cJ	MGP_BALBcJ_G0026199	protein coding gene	Chr2:103338736-103351875 (-)
C3H/HeJ	MGP_C3HHeJ_G0025949	protein coding gene	Chr2:106181969-106195017 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026650	protein coding gene	Chr2:111074301-111087329 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024036	protein coding gene	Chr2:98855319-98870203 (-)
CAST/EiJ	MGP_CASTEiJ_G0025414	protein coding gene	Chr2:106710166-106723188 (-)
CBA/J	MGP_CBAJ_G0025927	protein coding gene	Chr2:114904425-114920197 (-)
DBA/2J	MGP_DBA2J_G0026065	protein coding gene	Chr2:102602823-102616027 (-)
FVB/NJ	MGP_FVBNJ_G0026028	protein coding gene	Chr2:101583606-101596633 (-)
LP/J	MGP_LPJ_G0026168	protein coding gene	Chr2:107668537-107681767 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026052	protein coding gene	Chr2:118748455-118761483 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026704	protein coding gene	Chr2:106066095-106079123 (-)
PWK/PhJ	MGP_PWKPhJ_G0025149	protein coding gene	Chr2:102143566-102156656 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024949	protein coding gene	Chr2:105294667-105308932 (-)
WSB/EiJ	MGP_WSBEiJ_G0025481	protein coding gene	Chr2:106806068-106819096 (-)

Human Ortholog

RCN1, reticulocalbin 1

Vertebrate Orthologs

10

Human Ortholog

RCN1, reticulocalbin 1
Orthology source: HomoloGene, HGNC
Synonyms

HEL-S-84, PIG20, RCAL, RCN
Links

HGNC:9934

NCBI Gene ID: 5954

neXtProt AC: NX_Q15293

UniProt: Q15293
Chr Location

11p13; chr11:32090931-32105726 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20637
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RCN1
Protein SuperFamily

reticulocalbin
Gene Tree

Rcn1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Rcn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

421
Tissues

30
cDNA Data

77
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcn1

ZFIN rcn1

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Rcn1 interacts with 207 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS16498.1
UniGene

4876

Ensembl

ENSMUSG00000005973 (Evidence)
NCBI Gene

19672

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005973	Ensembl Gene Model \| MGI Sequence Detail	13029	C57BL/6J	± kb
transcript	ENSMUST00000006128	Ensembl \| MGI Sequence Detail	2720	Not Applicable
polypeptide	ENSMUSP00000006128	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013838 reticulocalbin-1

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 81

Genomic 3

cDNA 77

Primer pair 1

Microarray probesets 5

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MGD-MRK-25993

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:265611 Jin J, et al., Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016 Mar;54(3):410-23

TSS for Rcn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25561	Chr2:105399594-105399642 (-)	-299 bp
Tssr25560	Chr2:105399390-105399421 (-)	-87 bp
Tssr25559	Chr2:105399372-105399379 (-)	-57 bp
Tssr25558	Chr2:105399355-105399358 (-)	-38 bp
Tssr25557	Chr2:105399308-105399315 (-)	7 bp
Tssr25556	Chr2:105399286-105399300 (-)	26 bp
Tssr25555	Chr2:105399249-105399275 (-)	57 bp
Tssr25554	Chr2:105399208-105399243 (-)	93 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14