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Rps6ka1 Gene Detail
Summary
  • Symbol
    Rps6ka1
  • Name
    ribosomal protein S6 kinase polypeptide 1
  • Synonyms
    Rsk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104558
    NCBI Gene: 20111
  • Gene Overview
    MyGene.info: RPS6KA1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133847290-133887797 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.37 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104558
protein coding gene Chr4:133847290-133887797 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028905
protein coding gene Chr4:136147837-136190777 (-)
A/J MGP_AJ_G0028864
protein coding gene Chr4:130429540-130469470 (-)
AKR/J MGP_AKRJ_G0028816
protein coding gene Chr4:134155925-134199631 (-)
BALB/cJ MGP_BALBcJ_G0028887
protein coding gene Chr4:131069055-131109408 (-)
C3H/HeJ MGP_C3HHeJ_G0028601
protein coding gene Chr4:134390917-134432368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029329
protein coding gene Chr4:141040768-141089920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026600
protein coding gene Chr4:123496251-123538327 (-)
CAST/EiJ MGP_CASTEiJ_G0028034
protein coding gene Chr4:132514444-132557956 (-)
CBA/J MGP_CBAJ_G0028566
protein coding gene Chr4:144744012-144790819 (-)
DBA/2J MGP_DBA2J_G0028715
protein coding gene Chr4:130854223-130894600 (-)
FVB/NJ MGP_FVBNJ_G0028683
protein coding gene Chr4:129740718-129783704 (-)
LP/J MGP_LPJ_G0028816
protein coding gene Chr4:136243609-136286037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028708
protein coding gene Chr4:149236793-149294735 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029367
protein coding gene Chr4:134589781-134630647 (-)
PWK/PhJ MGP_PWKPhJ_G0027754
protein coding gene Chr4:127571848-127613987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027580
protein coding gene Chr4:130417209-130460131 (-)
WSB/EiJ MGP_WSBEiJ_G0028113
protein coding gene Chr4:134752582-134797916 (-)



Homology
more
  • Human Ortholog
    RPS6KA1, ribosomal protein S6 kinase A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPS6KA1, ribosomal protein S6 kinase A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HU-1, MAPKAPK1A, p90Rsk, RSK, RSK1
  • Links
    NCBI Gene ID: 6195
    neXtProt AC: NX_Q15418
    UniProt: Q15418

  • Chr Location
    1p36.11; chr1:26529758-26575029 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20111 NCBI Gene Model | MGI Sequence Detail 40508 C57BL/6J ±  kb
transcript NM_009097 RefSeq | MGI Sequence Detail 3151 C57BL/6  
polypeptide P18653 UniProt | EBI | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 138
    cDNA 137
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-25992
References
more
  • Summaries
    All 63
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
  • Latest
    J:235230 Rawashdeh O, et al., Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. J Neurochem. 2016 Sep;138(5):731-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory