Rps6ka1 MGI Mouse Gene Detail - MGI:104558 - ribosomal protein S6 kinase A1

Symbol

Rps6ka1
Name

ribosomal protein S6 kinase A1
Synonyms

Rsk1

Feature Type

protein coding gene
IDs

MGI:104558
NCBI Gene: 20111
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:133574601-133615108 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.37 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

1274 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104558	protein coding gene	Chr4:133574601-133615466 (-)
129S1/SvImJ	ENSMUSG00200018336	protein coding gene	Chr4:127007810-127047980 (-)
A/J	ENSMUSG00195040691	protein coding gene	Chr4:128341581-128381787 (-)
AKR/J	ENSMUSG00220041478	protein coding gene	Chr4:127333364-127373572 (-)
BALB/cJ	ENSMUSG00180041560	protein coding gene	Chr4:125980928-126021145 (-)
C3H/HeJ	ENSMUSG00175031677	protein coding gene	Chr4:126992831-127033040 (-)
C57BL/6NJ	ENSMUSG00215050446	protein coding gene	Chr4:128512421-128552924 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026600	protein coding gene	Chr4:123496251-123538327 (-)
CAST/EiJ	ENSTCUG00005042801	protein coding gene	Chr4:127900537-127940255 (-)
CBA/J	ENSMUSG00210053734	protein coding gene	Chr4:126616573-126656775 (-)
DBA/2J	ENSMUSG00185050464	protein coding gene	Chr4:128154431-128194648 (-)
FVB/NJ	ENSMUSG00205040811	protein coding gene	Chr4:126396328-126436645 (-)
JF1/MsJ	ENSUMUG00000023074	protein coding gene	Chr4:128828152-128868663 (-)
LP/J	ENSMUSG00230035983	protein coding gene	Chr4:131945831-131986408 (-)
NOD/ShiLtJ	ENSMUSG00190032120	protein coding gene	Chr4:126386781-126426998 (-)
NZO/HlLtJ	ENSMUSG00225025625	protein coding gene	Chr4:137872636-137913136 (-)
PWK/PhJ	ENSLUMG00010048223	protein coding gene	Chr4:125833454-125873619 (-)
SPRET/EiJ	ENSMSPG00010041073	protein coding gene	Chr4:127911326-127951169 (-)
WSB/EiJ	ENSIUOG00005038027	protein coding gene	Chr4:126273950-126313649 (-)

Human Ortholog

RPS6KA1, ribosomal protein S6 kinase A1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KA1, ribosomal protein S6 kinase A1
Synonyms

HU-1, MAPKAPK1, MAPKAPK1A, p90Rsk, RSK, RSK1
Links

HGNC:10430

NCBI Gene ID: 6195

UniProt: Q15418
Chr Location

1p36.11; chr1:26529756-26575030 (+) GRCh38

MGI Vertebrate Homology

Rps6ka1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RPS6KA1
Protein SuperFamily

Ribsml_S6_kin_2
Gene Tree

Rps6ka1

Diseases

1 with human RPS6KA1 associations

				Human Disease	Mouse Models
				alcohol-related birth defects IDs alcohol-related birth defects DOID:0050668

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

40
Radiation induced

1
Targeted

9
Genomic Mutations

4 involving Rps6ka1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

40
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

661
Tissues

55
cDNA Data

137
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps6ka1

ZFIN rps6ka3a

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All Sequences

79
RefSeq

10
UniProt

11
CCDS

CCDS18758.2, CCDS71487.1, CCDS71488.1

Ensembl

ENSMUSG00000003644 (Evidence)
NCBI Gene

20111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003644	Ensembl Gene Model \| MGI Sequence Detail	40508	C57BL/6J	± kb
transcript	ENSMUST00000137486	Ensembl \| MGI Sequence Detail	2296	Not Applicable
polypeptide	ENSMUSP00000119328	Ensembl \| MGI Sequence Detail	741	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000014282 ribosomal protein S6 kinase alpha-1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016239 Ribosomal protein S6 kinase II

IPR041906 Ribosomal S6 kinase, N-terminal catalytic domain

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P18653 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 141

cDNA 139

Primer pair 2

Antibodies 4

Microarray probesets 4

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MGD-MRK-25992

Summaries

All 86

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 23
Earliest

J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
Latest

J:378389 Liu X, et al., Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome. Cell Rep Med. 2026 Jan 20;7(1):102531

TSS for Rps6ka1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43831	Chr4:133615134-133615135 (-)	-27 bp
Tssr43830	Chr4:133615076-133615115 (-)	12 bp
Tssr43829	Chr4:133615055-133615073 (-)	44 bp
Tssr43828	Chr4:133602571-133602585 (-)	12,530 bp
Tssr43827	Chr4:133602539-133602550 (-)	12,563 bp
Tssr43826	Chr4:133601993-133602033 (-)	13,095 bp
Tssr43825	Chr4:133601969-133601980 (-)	13,133 bp
Tssr43824	Chr4:133600359-133600372 (-)	14,742 bp
Tssr43823	Chr4:133600308-133600355 (-)	14,776 bp
Tssr43822	Chr4:133599615-133599657 (-)	15,472 bp
Tssr43821	Chr4:133592627-133592648 (-)	22,470 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24