About   Help   FAQ
Gene Detail
ribosomal protein S6 kinase polypeptide 3
Synonyms Rsk2
Feature Type protein coding gene
Genetic Map
Chromosome X
73.27 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
ChrX:159210307-159368244 bp, + strand
From VEGA annotation of GRCm38

  157938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:37940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ribosomal protein S6 kinase II
Gene Tree: Rps6ka3

Human Homolog RPS6KA3, ribosomal protein S6 kinase, 90kDa, polypeptide 3
NCBI Gene ID 6197
neXtProt AC  NX_P51812
Human Synonyms  CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, p90-RSK2, pp90RSK2, RSK, RSK2, S6K-alpha3
Human Chr (Location)  Xp22.2-p22.1; chrX:20149911-20267071 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human RPS6KA3
alleles, and
All mutations/alleles(14) : Gene trapped(8) Radiation induced(1) Spontaneous(1) Targeted(4)
Genomic Mutations involving Rps6ka3 (2)
Incidental mutations (data from Mutagenetix )
Homozygotes/hemizygotes are a model for Coffin-Lowry Syndrome. One allele shows impaired osteoblast function with reduced long and craniofacial bones. Another allele shows infertility, lipodystrophy, impaired glycogen, glucose, and insulin metabolism, and impaired memory and coordination.
Human Diseases Modeled Using Mouse Rps6ka3 (1)    Alleles Annotated to Human Diseases(2)   
Rps6ka3 interacts with 479 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (22 annotations)
Process cell cycle, intracellular signal transduction, ...
Component cytoplasm, nucleus
Function ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ...
External Resources: FuncBase
Literature Summary: (6 records)
Data Summary: Results (45)    Tissues (31)    Images (13)
Theiler Stages: 5, 19, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 43
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(17) Genomic(1) cDNA(15) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000016505 (Evidence)
Ensembl Gene ModelENSMUSG00000031309 (Evidence)
Entrez Gene110651 (Evidence)
DFCITC1599183, TC1603641, TC1604508, TC1614243, TC1625640, TC1651511, TC1781222
DoTSDT.101735238, DT.529779, DT.532005, DT.91336024, DT.99840043
NIA Mouse Gene IndexU020358, U217856
PDB3UBD, 4GUE, 2QR7, 2QR8, 3G51, 4EL9
Consensus CDS ProjectCCDS30502.1
International Mouse Knockout Project StatusRps6ka3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016505 VEGA Gene Model | MGI Sequence Detail 157938 C57BL/6J ±  kb
transcript OTTMUST00000039877 VEGA | MGI Sequence Detail 7244 Not Applicable 
polypeptide OTTMUSP00000017786 VEGA | MGI Sequence Detail 740 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(8) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(444 from dbSNP Build 137)
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016239 Ribosomal protein S6 kinase II
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000014284 ribosomal protein S6 kinase alpha-3
References (Earliest) J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
(Latest) J:211945 Laugel-Haushalter V, et al., RSK2 is a modulator of craniofacial development. PLoS One. 2014;9(1):e84343
All references(59)
Disease annotation references (5)
accession IDs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory