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Tns1
Gene Detail
 Symbol
Name
ID
Tns1
tensin 1
MGI:104552
Synonyms 1110018I21Rik, 1200014E20Rik, E030018G17Rik, E030037J05Rik, Tns
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:73910232-74124449 bp, - strand
From VEGA annotation of GRCm38

  214218 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tns1

Human
homologs
Human Homolog TNS1, tensin 1
NCBI Gene ID 7145
neXtProt AC  NX_Q9HBL0
Human Synonyms  MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS
Human Chr (Location)  2q35-q36; chr2:217799789-217944073 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure.
 
Phenotype Images(2)
Interactions
Tns1 interacts with 387 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell-substrate junction assembly, fibroblast migration
Component cell-substrate junction, focal adhesion
Function actin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (35)    Tissues (24)    Images (6)
Theiler Stages: 10, 14, 15, 16, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 7
Northern blot 12
Western blot 8
RT-PCR 4
cDNA source data(188)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(191) Genomic(1) cDNA(189) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000047279 (Evidence)
Ensembl Gene ModelENSMUSG00000055322 (Evidence)
Entrez Gene21961 (Evidence)
UniGene309975
DFCITC1577382, TC1591177, TC1592782, TC1610113, TC1655942, TC1656988, TC1675970
DoTSDT.101385602, DT.110916900, DT.110916945, DT.491814, DT.87043388, DT.91313695, DT.94172179, DT.97382320, DT.97391468
NIA Mouse Gene IndexU043831
Consensus CDS ProjectCCDS48288.1
International Mouse Knockout Project StatusTns1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047279 VEGA Gene Model | MGI Sequence Detail 214218 C57BL/6J ±  kb
transcript OTTMUST00000122614 VEGA | MGI Sequence Detail 9904 Not Applicable 
polypeptide OTTMUSP00000067201 VEGA | MGI Sequence Detail 1867 Not Applicable 

For the selected sequences
All sequences(134) RefSeq(49) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(1762 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR014020 Tensin phosphatase, C2 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000016521 tensin-1
References (Earliest) J:29385 Jankowski SA, et al., Genes for tensin, villin and desmin are linked on mouse chromosome 1. Mamm Genome. 1995 Oct;6(10):744-5
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGD-MRK-25984, MGI:1915754, MGI:1918975, MGI:2138313, MGI:2444104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory