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Tns1 Gene Detail
Summary
  • Symbol
    Tns1
  • Name
    tensin 1
  • Synonyms
    1110018I21Rik, 1200014E20Rik, E030018G17Rik, E030037J05Rik, Tns
  • Feature Type
    protein coding gene
  • IDs
    MGI:104552
    NCBI Gene: 21961
  • Gene Overview
    MyGene.info: TNS1
Location & Maps
more
  • Sequence Map
    Chr1:73910232-74124449 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      214218 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.17 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TNS1, tensin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNS1, tensin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS
  • Links
    NCBI Gene ID: 7145
    neXtProt AC: NX_Q9HBL0

  • Chr Location
    2q35; chr2:217799789-217978827 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11219
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Tns1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047279 VEGA Gene Model | MGI Sequence Detail 214218 C57BL/6J ±  kb
transcript OTTMUST00000150486 VEGA | MGI Sequence Detail 5643 Not Applicable  
polypeptide OTTMUSP00000078017 VEGA | MGI Sequence Detail 1880 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1749 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 191
    Genomic 1
    cDNA 189
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-25984, MGI:1915754, MGI:1918975, MGI:2138313, MGI:2444104
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:29385 Jankowski SA, et al., Genes for tensin, villin and desmin are linked on mouse chromosome 1. Mamm Genome. 1995 Oct;6(10):744-5
  • Latest
    J:231945 Dina C, et al., Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct;47(10):1206-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory