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Apof
Gene Detail
Symbol

Name
ID
Apof
apolipoprotein F
MGI:104539
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:128267997-128270151 bp, + strand
From NCBI annotation of GRCm38

  2155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: APOF
Protein SuperFamily: apolipoprotein F, eukaryotic type
Gene Tree: Apof

Human
homologs
APOF, apolipoprotein F
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 319
neXtProt AC: NX_Q13790

Human Synonyms: Apo-F, LTIP

Human Chr (Location): 12q13.3; chr12:56360571-56362799 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired ABCG1-mediated cholesterol efflux.
 
Interactions
Apof interacts with 22 markers (Mir34b, Mir34c, Mir138-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cholesterol efflux, cholesterol metabolic process, ...
Component extracellular region, high-density lipoprotein particle, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (47)    Tissues (1)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN apof    NEW 
Molecular
reagents
All nucleic(59) cDNA(59)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047631 (Evidence)
Entrez Gene 103161 (Evidence)
UniGene 26513
DFCI TC1579251
DoTS DT.494209
NIA Mouse Gene Index U012179
Consensus CDS Project CCDS24268.1
International Mouse Phenotyping Consortium Status Apof
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 103161 NCBI Gene Model | MGI Sequence Detail 2155 C57BL/6J ±  kb
transcript NM_133997 RefSeq | MGI Sequence Detail 1930 C57BL/6 
polypeptide Q91V80 UniProt | EBI | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026114 Apolipoprotein F
Protein Ontology PR:000004156 apolipoprotein F
Graphical View of Protein Domain Structure
References
(Earliest) J:34160 Gwynn B, et al., Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics. 1996 Jul 15;35(2):389-91
(Latest) J:211505 Li L, et al., Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice. Biochem Biophys Res Commun. 2013 Nov 29;441(4):880-5
All references(34)
Other
accession IDs
MGD-MRK-25971, MGI:2143547

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory