About   Help   FAQ
Mgat3 Gene Detail
Summary
  • Symbol
    Mgat3
  • Name
    mannoside acetylglucosaminyltransferase 3
  • Synonyms
    1110038J12Rik, GnT-III
  • Feature Type
    protein coding gene
  • IDs
    MGI:104532
    NCBI Gene: 17309
  • Gene Overview
    MyGene.info: MGAT3
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:80173721-80215519 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104532
protein coding gene Chr15:80173651-80215519 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022095
protein coding gene Chr15:80496565-80547517 (+)
A/J MGP_AJ_G0022056
protein coding gene Chr15:77705911-77747550 (+)
AKR/J MGP_AKRJ_G0022031
protein coding gene Chr15:79874992-79919319 (+)
BALB/cJ MGP_BALBcJ_G0022062
protein coding gene Chr15:77713340-77756557 (+)
C3H/HeJ MGP_C3HHeJ_G0021833
protein coding gene Chr15:79871227-79914493 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022505
protein coding gene Chr15:83662557-83707828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020035
protein coding gene Chr15:74186854-74235698 (+)
CAST/EiJ MGP_CASTEiJ_G0021354
protein coding gene Chr15:80587328-80633164 (+)
CBA/J MGP_CBAJ_G0021798
protein coding gene Chr15:86320279-86361657 (+)
DBA/2J MGP_DBA2J_G0021927
protein coding gene Chr15:77198213-77240456 (+)
FVB/NJ MGP_FVBNJ_G0021905
protein coding gene Chr15:76218469-76261784 (+)
LP/J MGP_LPJ_G0021995
protein coding gene Chr15:80677657-80720518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021925
protein coding gene Chr15:91334455-91384180 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022519
protein coding gene Chr15:79911275-79955676 (+)
PWK/PhJ MGP_PWKPhJ_G0021096
protein coding gene Chr15:77210163-77254673 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020933
protein coding gene Chr15:79712482-79763843 (+)
WSB/EiJ MGP_WSBEiJ_G0021406
protein coding gene Chr15:80315893-80360678 (+)



Homology
more
  • Human Ortholog
    MGAT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MGAT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNT3, GNT-III
  • Links
    NCBI Gene ID: 4248
    neXtProt AC: NX_Q09327
    UniProt: Q09327

  • Chr Location
    22q13.1; chr22:39447166-39492194 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31088
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MGAT3
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced DEN and PB-induced hepatic tumors and reduced hepatocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042428 Ensembl Gene Model | MGI Sequence Detail 41799 C57BL/6J ±  kb
    transcript ENSMUST00000044970 Ensembl | MGI Sequence Detail 4665 Not Applicable  
    polypeptide ENSMUSP00000043077 Ensembl | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010380 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
    • InterPro Domains
      IPR006813 Glycosyl transferase, family 17
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 6
      cDNA 44

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-25963, MGI:1916016, MGI:2146079
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:237673 Kizuka Y, et al., Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016 Jan 01;473(1):21-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory