About   Help   FAQ
Bmp8a
Gene Detail
 Symbol
Name
ID
Bmp8a
bone morphogenetic protein 8a
MGI:104515
Synonyms Bmp7r1, OP2, osteogenic protein 2
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr4:123312645-123343252 bp, - strand
From VEGA annotation of GRCm38

  30608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp8a

Human
homologs
Human Homolog BMP8A, bone morphogenetic protein 8a
NCBI Gene ID 353500
neXtProt AC  NX_Q7Z5Y6
Human Chr (Location)  1p34.3; chr1:39491646-39529869 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
About half of the males homozygous for targeted mutations of this gene show spermatogenesis defects and germ cell degeneration.
 
Interactions
Bmp8a interacts with 106 markers (Mir7-2, Mir7b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (67)    Tissues (59)    Images (5)
Theiler Stages: 12, 16, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 2
Northern blot 8
RT-PCR 57
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008976 (Evidence)
Ensembl Gene ModelENSMUSG00000032726 (Evidence)
Entrez Gene12163 (Evidence)
UniGene439749
DFCITC1589393
DoTSDT.101350906, DT.40158303
NIA Mouse Gene IndexU025493
Consensus CDS ProjectCCDS18616.1, CCDS57293.1
International Mouse Knockout Project StatusBmp8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008976 VEGA Gene Model | MGI Sequence Detail 30608 C57BL/6J ±  kb
transcript OTTMUST00000020373 VEGA | MGI Sequence Detail 2405 Not Applicable 
polypeptide OTTMUSP00000009339 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(145 from dbSNP Build 137)    SNPs within 2kb including multiple locations(181)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000169 BMP8A
References (Earliest) J:19593 Ozkaynak E, et al., Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992 Dec 15;267(35):25220-7
(Latest) J:149242 Cameron TL, et al., Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20
All references(51)
Other
accession IDs
MGD-MRK-18614, MGD-MRK-25946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory