Bmp8a
Gene Detail

Symbol Name ID

Bmp8a bone morphogenetic protein 8a MGI:104515

Synonyms

Bmp7r1, OP2, osteogenic protein 2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr4:123312645-123343252 bp, - strand From VEGA annotation of GRCm38   30608 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp8a

Human homologs

Human Homolog		BMP8B, bone morphogenetic protein 8b
NCBI Gene ID		656
neXtProt AC		NX_P34820
Human Synonyms		BMP8, OP2
Human Chr (Location)		1p35-p32; chr1:40223903-40254533 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

About half of the males homozygous for targeted mutations of this gene show spermatogenesis defects and germ cell degeneration.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cartilage development, cell differentiation, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (67)    Tissues (59)    Images (5)
Theiler Stages: 12, 16, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	2
Northern blot	8
RT-PCR	57

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008976 (Evidence)
Ensembl Gene Model	ENSMUSG00000032726 (Evidence)
Entrez Gene	12163 (Evidence)
UniGene	439749
DFCI	TC1589393
DoTS	DT.101350906, DT.40158303
NIA Mouse Gene Index	U025493
Consensus CDS Project	CCDS18616.1, CCDS57293.1
International Mouse Knockout Project Status	Bmp8a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008976	VEGA Gene Model | MGI Sequence Detail	30608	C57BL/6J
transcript	OTTMUST00000020373	VEGA | MGI Sequence Detail	2405	Not Applicable
polypeptide	OTTMUSP00000009339	VEGA | MGI Sequence Detail	412	Not Applicable

All sequences(27) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000169	BMP8A

References

(Earliest) J:19593 Ozkaynak E, et al., Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992 Dec 15;267(35):25220-7
(Latest) J:149242 Cameron TL, et al., Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20
All references(48)

Other accession IDs

MGD-MRK-18614, MGD-MRK-25946