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Bmp8a
Gene Detail
Symbol

Name
ID
Bmp8a
bone morphogenetic protein 8a
MGI:104515
Synonyms
Bmp7r1, OP2, osteogenic protein 2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr4:123312645-123343252 bp, - strand
From VEGA annotation of GRCm38

  30608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

HCOP human homology predictions: BMP8A
Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp8a

Human
homologs
BMP8A, bone morphogenetic protein 8a
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 353500
neXtProt AC: NX_Q7Z5Y6

Human Chr (Location): 1p34.3; chr1:39491634-39529869 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Genomic Mutations involving Bmp8a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
About half of the males homozygous for targeted mutations of this gene show spermatogenesis defects and germ cell degeneration.
 
Interactions
Bmp8a interacts with 106 markers (Mir7-2, Mir7b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process BMP signaling pathway, cartilage development, ...
Component extracellular region, extracellular space
Function BMP receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (67)    Tissues (60)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 8
RT-PCR 57
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN bmp8a    NEW 
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008976 (Evidence)
Ensembl Gene Model ENSMUSG00000032726 (Evidence)
Entrez Gene 12163 (Evidence)
UniGene 439749
DFCI TC1589393
DoTS DT.101350906, DT.40158303
NIA Mouse Gene Index U025493
Consensus CDS Project CCDS18616.1, CCDS57293.1
International Mouse Phenotyping Consortium Status Bmp8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008976 VEGA Gene Model | MGI Sequence Detail 30608 C57BL/6J ±  kb
transcript OTTMUST00000020373 VEGA | MGI Sequence Detail 2405 Not Applicable 
polypeptide OTTMUSP00000009339 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(145 from dbSNP Build 137)    SNPs within 2kb including multiple locations(181)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000169 BMP8A
References
(Earliest) J:19593 Ozkaynak E, et al., Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992 Dec 15;267(35):25220-7
(Latest) J:149242 Cameron TL, et al., Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20
All references(50)
Other
accession IDs
MGD-MRK-18614, MGD-MRK-25946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory