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Nqo2
Gene Detail
 Symbol
Name
ID
Nqo2
NAD(P)H dehydrogenase, quinone 2
MGI:104513
Synonyms Nmor2, NRH: quinone oxidoreductase, Ox2, Ox-2
Feature Type protein coding gene
Genetic Map
Chromosome 13
14.01 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:33964659-33988465 bp, + strand
From NCBI annotation of GRCm38

  23807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Nqo2

Human
homologs
Human Homolog NQO2, NAD(P)H dehydrogenase, quinone 2
NCBI Gene ID 4835
neXtProt AC  NX_P16083
Human Synonyms  DHQV, DIA6, NMOR2, QR2
Human Chr (Location)  6p25.2; chr6:2999833-3019763 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NQO2
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(11) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygouse for disruptions in this gene have an essentially normal phenotype but with abnormalities in WBC counts and increased susceptibility to chemically induced tumors.
 
Interactions
Nqo2 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process oxidation-reduction process
Component cytoplasm, extracellular vesicular exosome, ...
Function dihydronicotinamide riboside quinone reductase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (4)
Theiler Stages: 23
Assay TypeResults
RNA in situ 4
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000046949 (Evidence)
Entrez Gene18105 (Evidence)
NIA Mouse Gene IndexU043327
EC1.10.99.2
Consensus CDS ProjectCCDS26442.1
International Mouse Knockout Project StatusNqo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18105 NCBI Gene Model | MGI Sequence Detail 23807 C57BL/6J ±  kb
transcript NM_020282 RefSeq | MGI Sequence Detail 3974 C57BL/6 
polypeptide Q9JI75 UniProt | EBI | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003680 Flavodoxin-like fold
Protein Ontology PR:000011389 ribosyldihydronicotinamide dehydrogenase [quinone]
Graphical View of Protein Domain Structure
References (Earliest) J:5757 Kumaki K, et al., Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977 Jan 10;252(1):157-65
(Latest) J:175324 Patrick BA, et al., Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer. Oncogene. 2011 Mar 3;30(9):1098-107
All references(42)
Other
accession IDs
MGD-MRK-13091, MGD-MRK-13093, MGD-MRK-25944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory