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Nqo2 Gene Detail
Summary
  • Symbol
    Nqo2
  • Name
    N-ribosyldihydronicotinamide quinone reductase 2
  • Synonyms
    Nmor2, NRH: quinone oxidoreductase, Ox2, Ox-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104513
    NCBI Gene: 18105
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:33964687-33988443 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.01 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104513
protein coding gene Chr13:33964466-33988465 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020444
protein coding gene Chr13:32066553-32091300 (+)
A/J MGP_AJ_G0020399
protein coding gene Chr13:31125312-31149413 (+)
AKR/J MGP_AKRJ_G0020376
protein coding gene Chr13:31860259-31886260 (+)
BALB/cJ MGP_BALBcJ_G0020394
protein coding gene Chr13:31202071-31225995 (+)
C3H/HeJ MGP_C3HHeJ_G0020193
protein coding gene Chr13:31792016-31815414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020828
protein coding gene Chr13:33132277-33160145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018415
protein coding gene Chr13:29440539-29463575 (+)
CAST/EiJ MGP_CASTEiJ_G0019709
protein coding gene Chr13:31449861-31473920 (+)
CBA/J MGP_CBAJ_G0020153
protein coding gene Chr13:34577525-34604108 (+)
DBA/2J MGP_DBA2J_G0020275
protein coding gene Chr13:30650379-30681029 (+)
FVB/NJ MGP_FVBNJ_G0020255
protein coding gene Chr13:30230389-30257201 (+)
LP/J MGP_LPJ_G0020351
protein coding gene Chr13:32294036-32319535 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020286
protein coding gene Chr13:34796481-34824891 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020871
protein coding gene Chr13:31518513-31547160 (+)
PWK/PhJ MGP_PWKPhJ_G0019464
protein coding gene Chr13:30766656-30795998 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019289
protein coding gene Chr13:30170921-30193095 (+)
WSB/EiJ MGP_WSBEiJ_G0019771
protein coding gene Chr13:31877699-31903890 (+)



Homology
more
  • Human Ortholog
    NQO2, N-ribosyldihydronicotinamide:quinone reductase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NQO2, N-ribosyldihydronicotinamide:quinone reductase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHQV, DIA6, NMOR2, QR2
  • Links
    NCBI Gene ID: 4835
    neXtProt AC: NX_P16083
    UniProt: P16083

  • Chr Location
    6p25.2; chr6:2999816-3019876 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NQO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions in this gene have an essentially normal phenotype but with abnormalities in WBC counts and increased susceptibility to chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046949 Ensembl Gene Model | MGI Sequence Detail 23757 C57BL/6J ±  kb
    transcript ENSMUST00000222740 Ensembl | MGI Sequence Detail 995 Not Applicable  
    polypeptide ENSMUSP00000152294 Ensembl | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13091, MGD-MRK-13093, MGD-MRK-25944
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory