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Tnfrsf4
Gene Detail
Symbol

Name
ID
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
MGI:104512
Synonyms
ACT35, CD134, Ox40, Txgp1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
87.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:156013843-156016612 bp, + strand
From VEGA annotation of GRCm38

  2770 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 4
Gene Tree: Tnfrsf4

Human
homologs
Human Homolog TNFRSF4, tumor necrosis factor receptor superfamily, member 4
NCBI Gene ID 7293
neXtProt AC  NX_P43489
Human Synonyms  ACT35, CD134, IMD16, OX40, TXGP1L
Human Chr (Location)  1p36; chr1:1211326-1214168 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TNFRSF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygote null mice have defects in T cell response to antigen including proliferation, production of cytokines, and generation of memory T cells.
 
Phenotype Images(1)
Interactions
Tnfrsf4 interacts with 22 markers (Mir27a, Mir27b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(7)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010989 (Evidence)
Ensembl Gene ModelENSMUSG00000029075 (Evidence)
Entrez Gene22163 (Evidence)
UniGene13885
DFCITC1586899, TC1650389
DoTSDT.101293666, DT.522461
NIA Mouse Gene IndexU005228
Consensus CDS ProjectCCDS19055.1
International Mouse Knockout Project StatusTnfrsf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010989 VEGA Gene Model | MGI Sequence Detail 2770 C57BL/6J ±  kb
transcript OTTMUST00000025777 VEGA | MGI Sequence Detail 1030 Not Applicable 
polypeptide OTTMUSP00000011828 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(7) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020445 Tumour necrosis factor receptor 4
Protein Ontology PR:000001960 tumor necrosis factor receptor superfamily member 4
References
(Earliest) J:15504 Calderhead DM, et al., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993 Nov 15;151(10):5261-71
(Latest) J:210316 Mahmud SA, et al., Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014 May;15(5):473-81
All references(110)
Other
accession IDs
MGD-MRK-13094, MGD-MRK-25943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory