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Tnfrsf4 Gene Detail
Summary
  • Symbol
    Tnfrsf4
  • Name
    tumor necrosis factor receptor superfamily, member 4
  • Synonyms
    ACT35, CD134, Ox40, Txgp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104512
    NCBI Gene: 22163
  • Gene Overview
    MyGene.info: TNFRSF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:156013843-156016612 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2770 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 87.68 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TNFRSF4, TNF receptor superfamily member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFRSF4, TNF receptor superfamily member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACT35, CD134, IMD16, OX40, TXGP1L
  • Links
    NCBI Gene ID: 7293
    neXtProt AC: NX_P43489
    UniProt: P43489

  • Chr Location
    1p36.33; chr1:1211326-1216812 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    52 phenotypes from multigenic genotypes
    1 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have defects in T cell response to antigen including proliferation, production of cytokines, and generation of memory T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010989 VEGA Gene Model | MGI Sequence Detail 2770 C57BL/6J ±  kb
transcript OTTMUST00000025777 VEGA | MGI Sequence Detail 1030 Not Applicable  
polypeptide OTTMUSP00000011828 VEGA | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001960 tumor necrosis factor receptor superfamily member 4
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR020445 Tumour necrosis factor receptor 4
    IPR034022 Tumour necrosis factor receptor 4, N-terminal
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13094, MGD-MRK-25943
References
more
  • Summaries
    All 138
    Gene Ontology 13
    Phenotypes 65
  • Earliest
    J:15504 Calderhead DM, et al., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993 Nov 15;151(10):5261-71
  • Latest
    J:244094 Lan P, et al., TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017 Jun 01;127(6):2222-2234

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory