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Tnfrsf4 Gene Detail
Summary
  • Symbol
    Tnfrsf4
  • Name
    tumor necrosis factor receptor superfamily, member 4
  • Synonyms
    ACT35, CD134, Ox40, Txgp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104512
    NCBI Gene: 22163
  • Gene Overview
    MyGene.info: TNFRSF4
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156013843-156016612 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 87.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104512
protein coding gene Chr4:156013595-156016613 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029243
protein coding gene Chr4:160383619-160386400 (+)
A/J MGP_AJ_G0029208
protein coding gene Chr4:153623700-153626481 (+)
AKR/J MGP_AKRJ_G0029156
protein coding gene Chr4:157804471-157807252 (+)
BALB/cJ MGP_BALBcJ_G0029224
protein coding gene Chr4:154099507-154102288 (+)
C3H/HeJ MGP_C3HHeJ_G0028945
protein coding gene Chr4:158367563-158370344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029673
protein coding gene Chr4:166065059-166067828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026917
protein coding gene Chr4:145901308-145904126 (+)
CAST/EiJ MGP_CASTEiJ_G0028357
protein coding gene Chr4:155805470-155808296 (+)
CBA/J MGP_CBAJ_G0028907
protein coding gene Chr4:171107601-171110382 (+)
DBA/2J MGP_DBA2J_G0029056
protein coding gene Chr4:153645030-153647811 (+)
FVB/NJ MGP_FVBNJ_G0029019
protein coding gene Chr4:152893007-152895776 (+)
LP/J MGP_LPJ_G0029146
protein coding gene Chr4:160319972-160322735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029046
protein coding gene Chr4:173899272-173902041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029705
protein coding gene Chr4:158449337-158452118 (+)
PWK/PhJ MGP_PWKPhJ_G0028078
protein coding gene Chr4:149784341-149787109 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027912
protein coding gene Chr4:152696660-152699428 (+)
WSB/EiJ MGP_WSBEiJ_G0028437
protein coding gene Chr4:158613540-158616321 (+)



Homology
more
  • Human Ortholog
    TNFRSF4, TNF receptor superfamily member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFRSF4, TNF receptor superfamily member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACT35, CD134, IMD16, OX40, TXGP1L
  • Links
    NCBI Gene ID: 7293
    neXtProt AC: NX_P43489
    UniProt: P43489

  • Chr Location
    1p36.33; chr1:1211326-1216812 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    52 phenotypes from multigenic genotypes
    1 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygote null mice have defects in T cell response to antigen including proliferation, production of cytokines, and generation of memory T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029075 Ensembl Gene Model | MGI Sequence Detail 2770 C57BL/6J ±  kb
transcript ENSMUST00000030952 Ensembl | MGI Sequence Detail 1030 Not Applicable  
polypeptide ENSMUSP00000030952 Ensembl | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR020445 Tumour necrosis factor receptor 4
    IPR034022 Tumour necrosis factor receptor 4, N-terminal
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13094, MGD-MRK-25943
References
more
  • Summaries
    All 142
    Developmental Gene Expression 1
    Gene Ontology 14
    Phenotypes 68
  • Earliest
    J:15504 Calderhead DM, et al., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993 Nov 15;151(10):5261-71
  • Latest
    J:259357 Geng J, et al., The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017 Jul;18(7):800-812

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory