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Tnfsf4
Gene Detail
Symbol

Name
ID
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
MGI:104511
Synonyms
Ath1, Ath-1, CD134L, gp34, OX40L, TXGP1, Txgp1l
Feature Type
protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:161395409-161418410 bp, + strand
From VEGA annotation of GRCm38

  23002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TNFSF4
Protein SuperFamily: tumour necrosis factor ligand superfamily member 4
Gene Tree: Tnfsf4

Human
homologs
TNFSF4, tumor necrosis factor (ligand) superfamily, member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7292
neXtProt AC: NX_P23510

Human Synonyms: CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1

Human Chr (Location): 1q25; chr1:173183731-173208072 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TNFSF4

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : QTL(6) Targeted(5) Transgenic(3)
 
Homozygous inactivation of this gene leads to an impaired contact hypersensitivity response due to defects in T cell priming and cytokine production. Homozygosity for a null allele confers resistance to autoimmune diabetes development in nonobese diabetic mice.
 
Human Diseases Modeled in Mice Using Tnfsf4 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Tnfsf4 interacts with 163 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process acute inflammatory response, blood vessel development, ...
Component cell surface, extracellular space, ...
Function cytokine activity, tumor necrosis factor receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (121)    Tissues (20)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042461 (Evidence)
Ensembl Gene Model ENSMUSG00000026700 (Evidence)
Entrez Gene 22164 (Evidence)
UniGene 4994
DFCI TC1591765
DoTS DT.91328630
NIA Mouse Gene Index U042225
PDB 2HEY, 2HEW
Consensus CDS Project CCDS15416.1
International Mouse Phenotyping Consortium Status Tnfsf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042461 VEGA Gene Model | MGI Sequence Detail 23002 C57BL/6J ±  kb
transcript OTTMUST00000111962 VEGA | MGI Sequence Detail 1842 Not Applicable 
polypeptide OTTMUSP00000062822 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(226 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000001949 tumor necrosis factor ligand superfamily member 4
References
(Earliest) J:32776 Paigen B, et al., Genetics of artherosclerosis susceptibility among inbred strains of mice. Mouse News Lett. 1986;76:73
(Latest) J:218141 Kamachi F, et al., OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo. Biochem Biophys Res Commun. 2014 Feb 7;444(2):235-40
All references(82)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1447, MGD-MRK-1450, MGD-MRK-18700, MGD-MRK-25942, MGI:88098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory