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Tnfsf4 Gene Detail
Summary
  • Symbol
    Tnfsf4
  • Name
    tumor necrosis factor (ligand) superfamily, member 4
  • Synonyms
    Ath1, Ath-1, CD134L, gp34, OX40L, TXGP1, Txgp1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:104511
    NCBI Gene: 22164
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161223009-161245777 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104511
 protein coding gene Chr1:161222980-161245981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016652
 protein coding gene Chr1:166670570-166693550 (+)
A/J MGP_AJ_G0016633
 protein coding gene Chr1:159887732-159910670 (+)
AKR/J MGP_AKRJ_G0016599
 protein coding gene Chr1:164758662-164781619 (+)
BALB/cJ MGP_BALBcJ_G0016594
 protein coding gene Chr1:160434305-160456891 (+)
C3H/HeJ MGP_C3HHeJ_G0016418
 protein coding gene Chr1:164971097-164994042 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017055
 protein coding gene Chr1:172313889-172338247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014764
 protein coding gene Chr1:152002946-152026295 (+)
CAST/EiJ MGP_CASTEiJ_G0015998
 protein coding gene Chr1:164590412-164614714 (+)
CBA/J MGP_CBAJ_G0016393
 protein coding gene Chr1:178426751-178449690 (+)
DBA/2J MGP_DBA2J_G0016499
 protein coding gene Chr1:158867445-158890033 (+)
FVB/NJ MGP_FVBNJ_G0016497
 protein coding gene Chr1:157274308-157298887 (+)
LP/J MGP_LPJ_G0016570
 protein coding gene Chr1:167763212-167786178 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016522
 protein coding gene Chr1:185976073-185999015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017091
 protein coding gene Chr1:164578888-164601851 (+)
PWK/PhJ MGP_PWKPhJ_G0015784
 protein coding gene Chr1:158032361-158055291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015571
 protein coding gene Chr1:163476230-163498316 (+)
WSB/EiJ MGP_WSBEiJ_G0016060
 protein coding gene Chr1:164765431-164788995 (+)



Homology
more
  • Human Ortholog
    TNFSF4, TNF superfamily member 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF4, TNF superfamily member 4
  • Synonyms
    CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1
  • Links
    NCBI Gene ID: 7292
    neXtProt AC: NX_P23510
    UniProt: P23510

  • Chr Location
    1q25.1; chr1:173172870-173450733 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tnfsf4 mouse models; 1 with human TNFSF4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 11 alleles in 13 genetic backgrounds
    5 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to an impaired contact hypersensitivity response due to defects in T cell priming and cytokine production. Homozygosity for a null allele confers resistance to autoimmune diabetes development in nonobese diabetic mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    20
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22164 NCBI Gene Model | MGI Sequence Detail 22769 C57BL/6J ±  kb
    transcript NM_009452 RefSeq | MGI Sequence Detail 1609 ZRU/MplStud  
    polypeptide P43488 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1447, MGD-MRK-1450, MGD-MRK-18700, MGD-MRK-25942, MGI:88098
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 24
      Phenotypes 48
    • Earliest
      J:8735 Paigen B, et al., Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3763-7
    • Latest
      J:322579 Li Q, et al., IL-10(-/-) Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways. Front Immunol. 2021;12:645653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory