Tnfsf4
Gene Detail

Symbol Name ID

Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 MGI:104511

Synonyms

Ath1, Ath-1, CD134L, gp34, OX40L, TXGP1, Txgp1l

Feature Type

protein coding gene

Genetic Map

Chromosome 1

69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr1:161395409-161418410 bp, + strand From VEGA annotation of GRCm38   23002 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumour necrosis factor ligand superfamily member 4
Gene Tree: Tnfsf4

Human homologs

Human Homolog		TNFSF4, tumor necrosis factor (ligand) superfamily, member 4
NCBI Gene ID		7292
neXtProt AC		NX_P23510
Human Synonyms		CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1
Human Chr (Location)		1q25; chr1:173152870-173176471 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TNFSF4

Alleles and phenotypes

All alleles(11) : Targeted(5) QTL(6)
 

Homozygous inactivation of this gene leads to an impaired contact hypersensitivity response due to defects in T cell priming and cytokine production. Homozygosity for a null allele confers resistance to autoimmune diabetes development in nonobese diabetic mice.

 
Human Diseases Modeled Using Mouse Tnfsf4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (67 annotations)

Process	acute inflammatory response, blood vessel development, ...
Component	cell surface, extracellular space, ...
Function	cytokine activity, tumor necrosis factor receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (121)    Tissues (20)    Images (19)
Theiler Stages: 23

Assay Type	Results
RNA in situ	121

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042461 (Evidence)
Ensembl Gene Model	ENSMUSG00000026700 (Evidence)
Entrez Gene	22164 (Evidence)
UniGene	4994
DFCI	TC1591765
DoTS	DT.91328630
NIA Mouse Gene Index	U042225
PDB	2HEW, 2HEY
Consensus CDS Project	CCDS15416.1
International Mouse Knockout Project Status	Tnfsf4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042461	VEGA Gene Model | MGI Sequence Detail	23002	C57BL/6J
transcript	OTTMUST00000111962	VEGA | MGI Sequence Detail	1842	Not Applicable
polypeptide	OTTMUSP00000062822	VEGA | MGI Sequence Detail	198	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(126 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000001949	tumor necrosis factor ligand superfamily member 4

References

(Earliest) J:32776 Paigen B, et al., Genetics of artherosclerosis susceptibility among inbred strains of mice. Mouse News Lett. 1986;76:73
(Latest) J:191423 Chappell CP, et al., Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med. 2012 Sep 24;209(10):1825-40
All references(86)

Other accession IDs

MGD-MRK-1447, MGD-MRK-1450, MGD-MRK-18700, MGD-MRK-25942, MGI:88098