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Sla Gene Detail
Summary
  • Symbol
    Sla
  • Name
    src-like adaptor
  • Synonyms
    Slap, Slap-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104295
    NCBI Gene: 20491
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66780819-66831829 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.30 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104295
protein coding gene Chr15:66780819-66831829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021908
protein coding gene Chr15:66301630-66354038 (-)
A/J MGP_AJ_G0021867
protein coding gene Chr15:63793154-63844441 (-)
AKR/J MGP_AKRJ_G0021849
protein coding gene Chr15:65553237-65607428 (-)
BALB/cJ MGP_BALBcJ_G0021874
protein coding gene Chr15:63969218-64027230 (-)
C3H/HeJ MGP_C3HHeJ_G0021647
protein coding gene Chr15:65676243-65729347 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022313
protein coding gene Chr15:68875849-68927526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019850
protein coding gene Chr15:60564563-60617067 (-)
CAST/EiJ MGP_CASTEiJ_G0021166
protein coding gene Chr15:66329607-66387283 (-)
CBA/J MGP_CBAJ_G0021613
protein coding gene Chr15:71164608-71218007 (-)
DBA/2J MGP_DBA2J_G0021738
protein coding gene Chr15:63574835-63626454 (-)
FVB/NJ MGP_FVBNJ_G0021720
protein coding gene Chr15:62613050-62663855 (-)
LP/J MGP_LPJ_G0021810
protein coding gene Chr15:66194717-66248624 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021743
protein coding gene Chr15:76259759-76311701 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022335
protein coding gene Chr15:65934043-65983114 (-)
PWK/PhJ MGP_PWKPhJ_G0020907
protein coding gene Chr15:63668265-63720068 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020748
protein coding gene Chr15:65793476-65845924 (-)
WSB/EiJ MGP_WSBEiJ_G0021218
protein coding gene Chr15:65899104-65951727 (-)



Homology
more
  • Human Ortholog
    SLA, Src like adaptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLA, Src like adaptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLA1, SLAP
  • Links
    NCBI Gene ID: 6503
    neXtProt AC: NX_Q13239
    UniProt: Q13239

  • Chr Location
    8q24.22; chr8:133036728-133103360 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 36206
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLA
  • Gene Tree
    Sla
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation in this locus affects T cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20491 NCBI Gene Model | MGI Sequence Detail 51011 C57BL/6J ±  kb
transcript NM_009192 RefSeq | MGI Sequence Detail 3135 C57BL/6  
polypeptide Q60898 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 46
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-25621
References
more
  • Summaries
    All 75
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 34
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory