Tyro3
Gene Detail

Symbol Name ID

Tyro3 TYRO3 protein tyrosine kinase 3 MGI:104294

Synonyms

Brt, Dtk, Etk-2, Rse, Sky, Sky, Tif

Feature Type

protein coding gene

Genetic Map

Chromosome 2

59.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr2:119797733-119818104 bp, + strand From VEGA annotation of GRCm38   20372 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree: Tyro3

Human homologs

Human Homolog		TYRO3, TYRO3 protein tyrosine kinase
NCBI Gene ID		7301
neXtProt AC		NX_Q06418
Human Synonyms		BYK, Dtk, RSE, Sky, Tif
Human Chr (Location)		15q15; chr15:41851220-41871536 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(40) : Targeted(3) Gene trapped(37)
 

Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	apoptotic cell clearance, cell adhesion, ...
Component	endoplasmic reticulum membrane, integral to membrane, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (101)    Tissues (45)    Images (19)
Theiler Stages: 20, 22, 23, 28

Assay Type	Results
RNA in situ	45
Northern blot	16
RT-PCR	4
RNase protection	36

cDNA source data(112)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(137) Genomic(18) cDNA(112) Primer pair(6) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016527 (Evidence)
Ensembl Gene Model	ENSMUSG00000027298 (Evidence)
Entrez Gene	22174 (Evidence)
UniGene	2901
DFCI	TC1577144, TC1597287
DoTS	DT.101387951, DT.101387954, DT.493284, DT.99846504
NIA Mouse Gene Index	U002324
EC	2.7.10.1
PDB	3QUP, 4FEQ, 4FF8
Consensus CDS Project	CCDS16611.1
International Mouse Knockout Project Status	Tyro3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016527	VEGA Gene Model | MGI Sequence Detail	20372	C57BL/6J
transcript	OTTMUST00000039943	VEGA | MGI Sequence Detail	3989	Not Applicable
polypeptide	OTTMUSP00000017810	VEGA | MGI Sequence Detail	880	Not Applicable

All sequences(62) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000016878	tyrosine-protein kinase receptor TYRO3

References

(Earliest) J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
(Latest) J:190898 Bauer T, et al., Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012 Oct 22;209(11):2033-47
All references(83)

Other accession IDs

MGD-MRK-25620, MGD-MRK-37049, MGI:2138899