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Tyro3
Gene Detail
 Symbol
Name
ID
Tyro3
TYRO3 protein tyrosine kinase 3
MGI:104294
Synonyms Brt, Dtk, Etk-2, Rse, Sky, Sky, Tif
Feature Type protein coding gene
Genetic Map
Chromosome 2
59.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:119797733-119818104 bp, + strand
From VEGA annotation of GRCm38

  20372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree: Tyro3

Human
homologs
Human Homolog TYRO3, TYRO3 protein tyrosine kinase
NCBI Gene ID 7301
neXtProt AC  NX_Q06418
Human Synonyms  BYK, Dtk, RSE, Sky, Tif
Human Chr (Location)  15q15; chr15:41559022-41579338 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(37) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tyro3 interacts with 216 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic cell clearance, cell adhesion, ...
Component cell, endoplasmic reticulum membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (101)    Tissues (45)    Images (19)
Theiler Stages: 20, 22, 23, 28
Assay TypeResults
RNA in situ 45
Northern blot 16
RT-PCR 4
RNase protection 36
cDNA source data(114)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) Genomic(18) cDNA(114) Primer pair(6) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016527 (Evidence)
Ensembl Gene ModelENSMUSG00000027298 (Evidence)
Entrez Gene22174 (Evidence)
UniGene2901
DFCITC1577144, TC1597287
DoTSDT.101387951, DT.101387954, DT.493284, DT.99846504
NIA Mouse Gene IndexU002324
EC2.7.10.1
PDB3QUP, 4FEQ, 4FF8
Consensus CDS ProjectCCDS16611.1, CCDS71119.1
International Mouse Knockout Project StatusTyro3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016527 VEGA Gene Model | MGI Sequence Detail 20372 C57BL/6J ±  kb
transcript OTTMUST00000039943 VEGA | MGI Sequence Detail 3989 Not Applicable 
polypeptide OTTMUSP00000017810 VEGA | MGI Sequence Detail 880 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(6) UniProt(2)
Polymorphisms RFLP(7) : SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000016878 tyrosine-protein kinase receptor TYRO3
References (Earliest) J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
(Latest) J:207107 Ji R, et al., TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol. 2013 Dec 15;191(12):6165-77
All references(89)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-25620, MGD-MRK-37049, MGI:2138899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory