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Tyro3 Gene Detail
Summary
  • Symbol
    Tyro3
  • Name
    TYRO3 protein tyrosine kinase 3
  • Synonyms
    Brt, Dtk, Etk-2, Rse, Sky, Sky, Tif
  • Feature Type
    protein coding gene
  • IDs
    MGI:104294
    NCBI Gene: 22174
  • Gene Overview
    MyGene.info: TYRO3
Location & Maps
more
  • Sequence Map
    Chr2:119797733-119818104 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20372 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM, cytoband F
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    TYRO3, TYRO3 protein tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TYRO3, TYRO3 protein tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    BYK, Dtk, Etk-2, Rek, RSE, Sky, Tif
  • Links
    NCBI Gene ID: 7301
    neXtProt AC: NX_Q06418

  • Chr Location
    15q15; chr15:41557871-41579338 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    52 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Gene trapped
    37
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Tyro3
  • Incidental Mutations
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016527 VEGA Gene Model | MGI Sequence Detail 20372 C57BL/6J ±  kb
transcript OTTMUST00000039943 VEGA | MGI Sequence Detail 3989 Not Applicable  
polypeptide OTTMUSP00000017810 VEGA | MGI Sequence Detail 880 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    158 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 139
    Genomic 18
    cDNA 114
    Primer pair 6
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-25620, MGD-MRK-37049, MGI:2138899
References
more
  • Summaries
    All 88
    Developmental Gene Expression 14
    Diseases 2
    Gene Ontology 16
    Phenotypes 38
  • Earliest
    J:18515 Lai C, et al., An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory