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Madcam1
Gene Detail
 Symbol
Name
ID
Madcam1
mucosal vascular addressin cell adhesion molecule 1
MGI:103579
Synonyms MGC:35998
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:79664574-79668536 bp, + strand
From NCBI annotation of GRCm38

  3963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8413  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Gene Tree: Madcam1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
 
Mice homozygous for a knock-out allele exhibit small Peyer's patches and decreased homing of IgA-secreting plasma cells in the lamina propria.
 
Interactions
Madcam1 interacts with 36 markers (Mir15a, Mir133b, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell adhesion, keratinocyte differentiation, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (20)    Tissues (10)    Images (6)
Theiler Stages: 20, 21, 22, 23, 24, 25
Assay TypeResults
Immunohistochemistry 14
RNA in situ 6
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(17) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000020310 (Evidence)
Entrez Gene17123 (Evidence)
UniGene391556
DFCITC1587891, TC1592164
DoTSDT.40158034, DT.91446656
Consensus CDS ProjectCCDS23981.1
International Mouse Knockout Project StatusMadcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17123 NCBI Gene Model | MGI Sequence Detail 3963 C57BL/6J ±  kb
transcript NM_013591 RefSeq | MGI Sequence Detail 1420 C57BL/6 
polypeptide Q61826 UniProt | EBI | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015169 Adhesion molecule, immunoglobulin-like
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000010041 mucosal addressin cell adhesion molecule 1
Graphical View of Protein Domain Structure
References (Earliest) J:13162 Berlin C, et al., Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993 Jul 16;74(1):185-5
(Latest) J:196959 Castagnaro L, et al., Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18;38(4):782-91
All references(61)
Other
accession IDs
MGD-MRK-24464, MGI:2143785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory