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Madcam1
Gene Detail
Symbol

Name
ID
Madcam1
mucosal vascular addressin cell adhesion molecule 1
MGI:103579
Synonyms
MGC:35998
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:79664574-79668536 bp, + strand
From Ensembl annotation of GRCm38

  3963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8413  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Gene Tree: Madcam1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
 
Mice homozygous for a knock-out allele exhibit small Peyer's patches and decreased homing of IgA-secreting plasma cells in the lamina propria.
 
Interactions
Madcam1 interacts with 36 markers (Mir15a, Mir133b, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell adhesion, keratinocyte differentiation, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (20)    Tissues (10)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 6
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(17) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000020310 (Evidence)
Entrez Gene17123 (Evidence)
UniGene391556
DFCITC1592164, TC1587891
DoTSDT.91446656, DT.40158034
Consensus CDS ProjectCCDS23981.1
International Mouse Knockout Project StatusMadcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020310 Ensembl Gene Model | MGI Sequence Detail 3963 C57BL/6J ±  kb
transcript ENSMUST00000020554 Ensembl | MGI Sequence Detail 1420 Not Applicable 
polypeptide ENSMUSP00000020554 Ensembl | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015169 Adhesion molecule, immunoglobulin-like
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000010041 mucosal addressin cell adhesion molecule 1
References
(Earliest) J:13162 Berlin C, et al., Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993 Jul 16;74(1):185-5
(Latest) J:196959 Castagnaro L, et al., Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18;38(4):782-91
All references(61)
Other
accession IDs
MGD-MRK-24464, MGI:2143785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory