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Skp1a
Gene Detail
Symbol

Name
ID
Skp1a
S-phase kinase-associated protein 1A
MGI:103575
Synonyms
2610043E24Rik, 2610206H23Rik, p19Skp1, Tceb1l
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:52231995-52246858 bp, + strand
From VEGA annotation of GRCm38

  14864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SKP1
Protein SuperFamily: E3 ubiquitin ligase SCF complex, Skp subunit
Gene Tree: Skp1a

Human
homologs
SKP1, S-phase kinase-associated protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6500
neXtProt AC: NX_P63208

Human Synonyms: EMC19, OCP2, OCP-II, p19A, SKP1A, TCEB1L

Human Chr (Location): 5q31; chr5:134156391-134177033 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(25)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Skp1a interacts with 165 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process histone H2A monoubiquitination, protein ubiquitination, ...
Component Cul7-RING ubiquitin ligase complex, cytosol, ...
Function protein binding, ubiquitin-protein transferase activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (89)    Tissues (67)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
Northern blot 1
RT-PCR 14
cDNA source data(323)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SKP1 ; Xenbase skp1 ; ZFIN skp1    NEW 
Molecular
reagents
All nucleic(327) cDNA(324) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005625 (Evidence)
Ensembl Gene Model ENSMUSG00000036309 (Evidence)
Entrez Gene 21402 (Evidence)
UniGene 42944
DFCI TC1646925, TC1573967
DoTS DT.101205392, DT.110506049, DT.94166513, DT.537126
NIA Mouse Gene Index U012582
Consensus CDS Project CCDS24669.1
International Mouse Phenotyping Consortium Status Skp1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005625 VEGA Gene Model | MGI Sequence Detail 14864 C57BL/6J ±  kb
transcript OTTMUST00000012513 VEGA | MGI Sequence Detail 1754 Not Applicable 
polypeptide OTTMUSP00000005803 VEGA | MGI Sequence Detail 163 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR016897 E3 ubiquitin ligase, SCF complex, Skp subunit
InterPro IPR001232 SKP1 component
InterPro IPR016072 SKP1 component, dimerisation
InterPro IPR016073 SKP1 component, POZ
Protein Ontology PR:000000045 S-phase kinase-associated protein 1A
References
(Earliest) J:11083 Bach I, et al., Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990 Sep;8(1):155-64
(Latest) J:205916 Yumimoto K, et al., Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem. 2013 Nov 8;288(45):32766-76
All references(51)
Other
accession IDs
MGD-MRK-24460, MGI:1917574, MGI:1923841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory