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Skp1a
Gene Detail
 Symbol
Name
ID
Skp1a
S-phase kinase-associated protein 1A
MGI:103575
Synonyms 2610043E24Rik, 2610206H23Rik, p19Skp1, Tceb1l
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:52231995-52246858 bp, + strand
From VEGA annotation of GRCm38

  14864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin ligase SCF complex, Skp subunit
Gene Tree: Skp1a

Human
homologs
Human Homolog SKP1, S-phase kinase-associated protein 1
NCBI Gene ID 6500
neXtProt AC  NX_P63208
Human Synonyms  EMC19, OCP2, OCP-II, p19A, SKP1A, TCEB1L
Human Chr (Location)  5q31; chr5:134156391-134177033 (-)  GRCh38
Alleles
and
phenotypes
All alleles(25) : Gene trapped(25)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process histone H2A monoubiquitination, protein ubiquitination, ...
Component Cul7-RING ubiquitin ligase complex, cytosol, ...
Function protein binding, ubiquitin-protein transferase activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (96)    Tissues (72)    Images (9)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 74
Northern blot 1
RT-PCR 21
cDNA source data(323)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(327) cDNA(324) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005625 (Evidence)
Ensembl Gene ModelENSMUSG00000036309 (Evidence)
Entrez Gene21402 (Evidence)
UniGene42944
DFCITC1573967, TC1646925
DoTSDT.101205392, DT.110506049, DT.537126, DT.94166513
NIA Mouse Gene IndexU012582
Consensus CDS ProjectCCDS24669.1
International Mouse Knockout Project StatusSkp1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005625 VEGA Gene Model | MGI Sequence Detail 14864 C57BL/6J ±  kb
transcript OTTMUST00000012512 VEGA | MGI Sequence Detail 1440 Not Applicable 
polypeptide OTTMUSP00000005802 VEGA | MGI Sequence Detail 163 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR016897 E3 ubiquitin ligase, SCF complex, Skp subunit
InterPro IPR001232 SKP1 component
InterPro IPR016072 SKP1 component, dimerisation
InterPro IPR016073 SKP1 component, POZ
Protein Ontology PR:000000045 S-phase kinase-associated protein 1A
References (Earliest) J:11083 Bach I, et al., Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990 Sep;8(1):155-64
(Latest) J:205916 Yumimoto K, et al., Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem. 2013 Nov 8;288(45):32766-76
All references(54)
Other
accession IDs
MGD-MRK-24460, MGI:1917574, MGI:1923841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory