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Amph
Gene Detail
Symbol

Name
ID
Amph
amphiphysin
MGI:103574
Feature Type
protein coding gene
Genetic Map
Chromosome 13
6.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:18948371-19150913 bp, + strand
From Ensembl annotation of GRCm38

  202543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121585  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Amph

Human
homologs
Human Homolog AMPH, amphiphysin
NCBI Gene ID 273
neXtProt AC  NX_P49418
Human Synonyms  AMPH1
Human Chr (Location)  7p14-p13; chr7:38383696-38631567 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation of this gene exhibit learning deficits and synaptic vesicle recycling defects, and die between 2 to 5 months of age from rare irreversible seizures.
 
Interactions
Amph interacts with 242 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process learning, synaptic vesicle endocytosis
Component axon terminus, cell, ...
Function phospholipid binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (22)    Tissues (22)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 1
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000021314 (Evidence)
Entrez Gene218038 (Evidence)
UniGene101650
DFCITC1575858, TC1601312, TC1596118
DoTSDT.101725192, DT.103562549, DT.50316707
NIA Mouse Gene IndexU014580
Consensus CDS ProjectCCDS26258.1
International Mouse Knockout Project StatusAmph
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021314 Ensembl Gene Model | MGI Sequence Detail 202543 C57BL/6J ±  kb
transcript ENSMUST00000003345 Ensembl | MGI Sequence Detail 3193 Not Applicable 
polypeptide ENSMUSP00000003345 Ensembl | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(1774 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003005 Amphiphysin
InterPro IPR003017 Amphiphysin, isoform 1
InterPro IPR027267 Arfaptin homology (AH) domain/BAR domain
InterPro IPR004148 BAR domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004004 amphiphysin
References
(Earliest) J:28029 Jenkins NA, et al., Amphiphysin (Amph) maps to the proximal region of mouse chromosome 13. Genomics. 1995 Jul 20;28(2):363-5
(Latest) J:204152 Onishi K, et al., Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013 Dec 4;33(49):19071-85
All references(40)
Other
accession IDs
MGD-MRK-24459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory