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Cebpd Gene Detail
Summary
  • Symbol
    Cebpd
  • Name
    CCAAT/enhancer binding protein (C/EBP), delta
Location & Maps
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  • Sequence Map
    Chr16:15887286-15888466 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1181 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CEBPD, CCAAT/enhancer binding protein delta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CEBPD, CCAAT/enhancer binding protein delta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C/EBP-delta, CELF, CRP3, NF-IL6-beta
  • Links
    NCBI Gene ID: 1052
    neXtProt AC: NX_P49716

  • Chr Location
    8p11.2-p11.1; chr8:47736914-47738164 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Mice homozygous for a knock-out allele are viable and healthy and perform normally on several behavioral tasks, but display enhanced contextual fear conditioning. Mice homozygous for a second knock-out allele exhibit nearly normal or only slightly impaired adipocyte differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071637 Ensembl Gene Model | MGI Sequence Detail 1181 C57BL/6J ±  kb
transcript ENSMUST00000096232 Ensembl | MGI Sequence Detail 1180 Not Applicable  
polypeptide Q00322 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR031106 CCAAT/enhancer-binding protein C/EBP
    IPR016468 CCAAT/enhancer-binding protein, chordates
Molecular
Reagents
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  • All nucleic 49
    Genomic 5
    cDNA 41
    Primer pair 1
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-24458
References
more
  • Summaries
    All 98
    Developmental Gene Expression 20
    Gene Ontology 13
    Phenotypes 26
  • Earliest
    J:23758 Cao Z, et al., Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991 Sep;5(9):1538-52
  • Latest
    J:224441 Lim GE, et al., 14-3-3zeta coordinates adipogenesis of visceral fat. Nat Commun. 2015;6:7671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory