Cebpd
Gene Detail

Symbol Name ID

Cebpd CCAAT/enhancer binding protein (C/EBP), delta MGI:103573

BioType Conflict

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:15887286-15888466 bp, + strand From Ensembl annotation of GRCm38   1181 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3808  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 zebrafish

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpd

Human homologs

Human Homolog		CEBPD, CCAAT/enhancer binding protein (C/EBP), delta
NCBI Gene ID		1052
neXtProt AC		NX_P49716
Human Synonyms		C/EBP-delta, CELF, CRP3, NF-IL6-beta
Human Chr (Location)		8p11.2-p11.1; chr8:48649476-48650726 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele are viable and healthy and perform normally on several behavioral tasks, but display enhanced contextual fear conditioning. Mice homozygous for a second knock-out allele exhibit nearly normal or only slightly impaired adipocyte differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	fat cell differentiation, inner ear development, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (141)    Tissues (122)    Images (8)
Theiler Stages: 1, 2, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	118
Northern blot	9
Western blot	8

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(5) cDNA(42) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000071637 (Evidence)
Entrez Gene	12609 (Evidence)
UniGene	347407
DFCI	TC1578875
DoTS	DT.101364847, DT.110721652, DT.531992, DT.94349867
NIA Mouse Gene Index	U016849
International Mouse Knockout Project Status	Cebpd

Sequences

Length	Strain/Species
genomic	ENSMUSG00000071637	Ensembl Gene Model | MGI Sequence Detail	1181	C57BL/6J
transcript	ENSMUST00000096232	Ensembl | MGI Sequence Detail	1180	Not Applicable
polypeptide	Q00322	UniProt | EBI | MGI Sequence Detail	268	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(4) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR016468	CCAAT/enhancer-binding
Protein Ontology	PR:000005309	CCAAT/enhancer-binding protein delta

Graphical View of Protein Domain Structure

References

(Earliest) J:23758 Cao Z, et al., Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 1991 Sep;5(9):1538-52
(Latest) J:192313 Yan C, et al., CCAAT/Enhancer-Binding Protein delta Is a Critical Mediator of Lipopolysaccharide-Induced Acute Lung Injury. Am J Pathol. 2013 Feb;182(2):420-30
All references(91)

Other accession IDs

MGD-MRK-24458