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Cebpe Gene Detail
Summary
  • Symbol
    Cebpe
  • Name
    CCAAT/enhancer binding protein epsilon
  • Synonyms
    C/EBPe, C/EBPepsilon, CRP1, LOC239097
  • Feature Type
    protein coding gene
  • IDs
    MGI:103572
    NCBI Gene: 110794
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54947823-54949604 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103572
 protein coding gene Chr14:54947817-54949631 (-)
129S1/SvImJ ENSMUSG00200039184
 protein coding gene Chr14:43527421-43529232 (-)
A/J ENSMUSG00195028557
 protein coding gene Chr14:43751731-43753542 (-)
AKR/J ENSMUSG00220026852
 protein coding gene Chr14:43079681-43081492 (-)
BALB/cJ ENSMUSG00180047825
 protein coding gene Chr14:43375495-43377306 (-)
C3H/HeJ ENSMUSG00175037581
 protein coding gene Chr14:45057887-45059698 (-)
C57BL/6NJ ENSMUSG00215045335
 protein coding gene Chr14:43270781-43272595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019269
 protein coding gene Chr14:46136984-46138797 (-)
CAST/EiJ ENSTCUG00005044292
 protein coding gene Chr14:45055591-45057402 (-)
CBA/J ENSMUSG00210044256
 protein coding gene Chr14:43738424-43740235 (-)
DBA/2J ENSMUSG00185051679
 protein coding gene Chr14:48784424-48786235 (-)
FVB/NJ ENSMUSG00205033804
 protein coding gene Chr14:43127345-43129156 (-)
JF1/MsJ ENSUMUG00000026526
 protein coding gene Chr14:60033762-60035576 (-)
LP/J ENSMUSG00230051663
 protein coding gene Chr14:60893346-60903126 (-)
NOD/ShiLtJ ENSMUSG00190038550
 protein coding gene Chr14:43488234-43490045 (-)
NZO/HlLtJ ENSMUSG00225049250
 protein coding gene Chr14:51191495-51201276 (-)
PWK/PhJ ENSLUMG00010046796
 protein coding gene Chr14:42961335-42963146 (-)
SPRET/EiJ ENSMSPG00010040053
 protein coding gene Chr14:46358163-46359939 (-)
WSB/EiJ ENSIUOG00005034551
 protein coding gene Chr14:42952263-42954074 (-)



Homology
more
  • Human Ortholog
    CEBPE, CCAAT enhancer binding protein epsilon
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEBPE, CCAAT enhancer binding protein epsilon
  • Synonyms
    c/EBP epsilon, C/EBP-epsilon, CRP1, IMD108, SGD1
  • Links
    NCBI Gene ID: 1053
    UniProt: Q15744

  • Chr Location
    14q11.2; chr14:23117036-23120256 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CEBPE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    12
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110794 NCBI Gene Model | MGI Sequence Detail 1782 C57BL/6J ±  kb
    transcript NM_207131 RefSeq | MGI Sequence Detail 1208 ZRU/MplStud  
    polypeptide Q6PZD9 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-24457, MGI:2685140
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:30069 Williams SC, et al., A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 1991 Sep;5(9):1553-67
    • Latest
      J:383004 Lokken-Toyli KL, et al., Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice. Nat Microbiol. 2024 Mar;9(3):727-736
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory