About   Help   FAQ
Cebpe Gene Detail
Summary
  • Symbol
    Cebpe
  • Name
    CCAAT/enhancer binding protein (C/EBP), epsilon
  • Synonyms
    C/EBPe, C/EBPepsilon, CRP1, LOC239097
  • Feature Type
    protein coding gene
  • IDs
    MGI:103572
    NCBI Gene: 110794
  • Gene Overview
    MyGene.info: CEBPE
Location & Maps
more
  • Sequence Map
    Chr14:54710363-54712174 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1812 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CEBPE, CCAAT/enhancer binding protein epsilon
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CEBPE, CCAAT/enhancer binding protein epsilon
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C/EBP-epsilon, CRP1
  • Links
    NCBI Gene ID: 1053
    neXtProt AC: NX_Q15744

  • Chr Location
    14q11.2; chr14:23117306-23119985 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CEBPE associations

Human Disease Mouse Models
       Specific Granule Deficiency; SGD   OMIM: 245480
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Cebpe
  • Incidental Mutations
Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 110794 NCBI Gene Model | MGI Sequence Detail 1812 C57BL/6J ±  kb
transcript NM_207131 RefSeq | MGI Sequence Detail 1238 C57BL/6  
polypeptide Q6PZD9 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    54 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005310 CCAAT/enhancer-binding protein epsilon
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR031106 CCAAT/enhancer-binding protein C/EBP
    IPR016468 CCAAT/enhancer-binding protein, chordates
Molecular
Reagents
less
  • All nucleic 15
    Genomic 3
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-24457, MGI:2685140
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:28024 Jenkins NA, et al., Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Genomics. 1995 Jul 20;28(2):333-6
  • Latest
    J:227992 Paul F, et al., Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell. 2015 Dec 17;163(7):1663-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory