Cebpe
Gene Detail

Symbol Name ID

Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon MGI:103572

Synonyms

C/EBPe, C/EBPepsilon, CRP1, LOC239097

Feature Type

protein coding gene

Genetic Map

Chromosome 14

27.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:54710363-54712174 bp, - strand From NCBI annotation of GRCm38   1812 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpe

Human homologs

Human Homolog		CEBPE, CCAAT/enhancer binding protein (C/EBP), epsilon
NCBI Gene ID		1053
neXtProt AC		NX_Q15744
Human Synonyms		C/EBP-epsilon, CRP1
Human Chr (Location)		14q11.2; chr14:23586515-23588820 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CEBPE

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cytokine biosynthetic process, defense response to bacterium, ...
Component	nucleus
Function	DNA binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (12)    Images (2)
Theiler Stages: 22, 26, 28

Assay Type	Results
Northern blot	9
RT-PCR	12

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(3) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000052435 (Evidence)
Entrez Gene	110794 (Evidence)
UniGene	236223
DFCI	TC1590508
DoTS	DT.103544947
NIA Mouse Gene Index	U248406
Consensus CDS Project	CCDS27100.1
International Mouse Knockout Project Status	Cebpe

Sequences

Length	Strain/Species
genomic	110794	NCBI Gene Model | MGI Sequence Detail	1812	C57BL/6J
transcript	NM_207131	RefSeq | MGI Sequence Detail	1238	C57BL/6
polypeptide	Q6PZD9	UniProt | EBI | MGI Sequence Detail	281	Not Applicable

All sequences(16) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR016468	CCAAT/enhancer-binding
Protein Ontology	PR:000005310	CCAAT/enhancer-binding protein epsilon

Graphical View of Protein Domain Structure

References

(Earliest) J:28024 Jenkins NA, et al., Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Genomics. 1995 Jul 20;28(2):333-6
(Latest) J:190743 Kyme P, et al., C/EBPepsilon mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J Clin Invest. 2012 Sep 4;122(9):3316-29
All references(44)

Other accession IDs

MGD-MRK-24457, MGI:2685140