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Cebpe
Gene Detail
Symbol

Name
ID
Cebpe
CCAAT/enhancer binding protein (C/EBP), epsilon
MGI:103572
Synonyms
C/EBPe, C/EBPepsilon, CRP1, LOC239097
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:54710363-54712174 bp, - strand
From NCBI annotation of GRCm38

  1812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpe

Human
homologs
Human Homolog CEBPE, CCAAT/enhancer binding protein (C/EBP), epsilon
NCBI Gene ID 1053
neXtProt AC  NX_Q15744
Human Synonyms  C/EBP-epsilon, CRP1
Human Chr (Location)  14q11.2; chr14:23117306-23119611 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CEBPE
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.
 
Phenotype Images(1)
Interactions
Cebpe interacts with 38 markers (Mir15b, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cytokine biosynthetic process, defense response to bacterium, ...
Component nucleus
Function DNA binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (12)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
RT-PCR 12
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(3) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000052435 (Evidence)
Entrez Gene110794 (Evidence)
UniGene236223
DFCITC1590508
DoTSDT.103544947
NIA Mouse Gene IndexU248406
Consensus CDS ProjectCCDS27100.1
International Mouse Knockout Project StatusCebpe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 110794 NCBI Gene Model | MGI Sequence Detail 1812 C57BL/6J ±  kb
transcript NM_207131 RefSeq | MGI Sequence Detail 1238 C57BL/6 
polypeptide Q6PZD9 UniProt | EBI | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016468 CCAAT/enhancer-binding
Protein Ontology PR:000005310 CCAAT/enhancer-binding protein epsilon
Graphical View of Protein Domain Structure
References
(Earliest) J:28024 Jenkins NA, et al., Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Genomics. 1995 Jul 20;28(2):333-6
(Latest) J:214157 Glenthoj A, et al., Human alpha-defensin expression is not dependent on CCAAT/enhancer binding protein-epsilon in a murine model. PLoS One. 2014;9(3):e92471
All references(47)
Other
accession IDs
MGD-MRK-24457, MGI:2685140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory