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Kpna1 Gene Detail
Summary
  • Symbol
    Kpna1
  • Name
    karyopherin (importin) alpha 1
  • Synonyms
    importin alpha 5, m-importin-alpha-S1, mSRP1, NPI1, Rch2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103560
    NCBI Gene: 16646
  • Gene Overview
    MyGene.info: KPNA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:35978750-36037131 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      58382 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.43 cM, cytoband B4-B5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KPNA1, karyopherin subunit alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KPNA1, karyopherin subunit alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOA5, NPI-1, RCH2, SRP1
  • Links
    NCBI Gene ID: 3836
    neXtProt AC: NX_P52294
    UniProt: P52294

  • Chr Location
    3q21.1; chr3:122421901-122514939 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele do not display any nervous system or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    417
  • Tissues
    90
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038076 VEGA Gene Model | MGI Sequence Detail 58382 C57BL/6J ±  kb
    transcript OTTMUST00000098056 VEGA | MGI Sequence Detail 5039 Not Applicable  
    polypeptide OTTMUSP00000055030 VEGA | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      318 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24445, MGI:2146643
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:19623 Cortes P, et al., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7
    • Latest
      J:238763 Choo HJ, et al., Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import. Stem Cells. 2016 Jul 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory