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Kpna1 Gene Detail
Summary
  • Symbol
    Kpna1
  • Name
    karyopherin (importin) alpha 1
  • Synonyms
    importin alpha 5, m-importin-alpha-S1, mSRP1, NPI1, Rch2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103560
    NCBI Gene: 16646
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:35803692-35857506 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.43 cM, cytoband B4-B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103560
 protein coding gene Chr16:35799120-35857506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022775
 protein coding gene Chr16:34337428-34404731 (+)
A/J MGP_AJ_G0022740
 protein coding gene Chr16:32670222-32729950 (+)
AKR/J MGP_AKRJ_G0022713
 protein coding gene Chr16:33816858-33880979 (+)
BALB/cJ MGP_BALBcJ_G0022742
 protein coding gene Chr16:32791525-32849888 (+)
C3H/HeJ MGP_C3HHeJ_G0022507
 protein coding gene Chr16:33943016-34004720 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023191
 protein coding gene Chr16:35080630-35142610 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020709
 protein coding gene Chr16:33026104-33086130 (+)
CAST/EiJ MGP_CASTEiJ_G0022035
 protein coding gene Chr16:34173629-34234050 (+)
CBA/J MGP_CBAJ_G0022477
 protein coding gene Chr16:36502184-36567227 (+)
DBA/2J MGP_DBA2J_G0022610
 protein coding gene Chr16:32494143-32552850 (+)
FVB/NJ MGP_FVBNJ_G0022585
 protein coding gene Chr16:32489281-32547156 (+)
LP/J MGP_LPJ_G0022677
 protein coding gene Chr16:34065988-34131025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022604
 protein coding gene Chr16:35770836-35832667 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023203
 protein coding gene Chr16:33873941-33940370 (+)
PWK/PhJ MGP_PWKPhJ_G0021776
 protein coding gene Chr16:32911430-32971836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021607
 protein coding gene Chr16:33689168-33740752 (+)
WSB/EiJ MGP_WSBEiJ_G0022079
 protein coding gene Chr16:33804325-33865131 (+)



Homology
more
  • Human Ortholog
    KPNA1, karyopherin subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNA1, karyopherin subunit alpha 1
  • Synonyms
    IPOA5, NPI-1, RCH2, SRP1
  • Links
    NCBI Gene ID: 3836
    neXtProt AC: NX_P52294
    UniProt: P52294

  • Chr Location
    3q21.1; chr3:122421901-122514939 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele do not display any nervous system or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1110
  • Tissues
    101
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16646 NCBI Gene Model | MGI Sequence Detail 53815 C57BL/6J ±  kb
    transcript NM_008465 RefSeq | MGI Sequence Detail 4022 C57BL/6  
    polypeptide Q60960 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24445, MGI:2146643
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:19623 Cortes P, et al., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7
    • Latest
      J:294736 Marvaldi L, et al., Importin alpha3 regulates chronic pain pathways in peripheral sensory neurons. Science. 2020 Aug 14;369(6505):842-846
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/09/2022
    MGI 6.21     		The Jackson Laboratory