Kpna1 MGI Mouse Gene Detail - MGI:103560 - karyopherin (importin) alpha 1

Symbol

Kpna1
Name

karyopherin (importin) alpha 1
Synonyms

importin alpha 5, m-importin-alpha-S1, mSRP1, NPI1, Rch2

Feature Type

protein coding gene
IDs

MGI:103560
NCBI Gene: 16646
Gene Overview

MyGene.info: KPNA1
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:35983288-36037136 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM, cytoband B4-B5
Mapping Data

3 experiments

SNPs within 2kb

313 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103560	protein coding gene	Chr16:35978750-36037136 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022775	protein coding gene	Chr16:34337428-34404731 (+)
A/J	MGP_AJ_G0022740	protein coding gene	Chr16:32670222-32729950 (+)
AKR/J	MGP_AKRJ_G0022713	protein coding gene	Chr16:33816858-33880979 (+)
BALB/cJ	MGP_BALBcJ_G0022742	protein coding gene	Chr16:32791525-32849888 (+)
C3H/HeJ	MGP_C3HHeJ_G0022507	protein coding gene	Chr16:33943016-34004720 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023191	protein coding gene	Chr16:35080630-35142610 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020709	protein coding gene	Chr16:33026104-33086130 (+)
CAST/EiJ	MGP_CASTEiJ_G0022035	protein coding gene	Chr16:34173629-34234050 (+)
CBA/J	MGP_CBAJ_G0022477	protein coding gene	Chr16:36502184-36567227 (+)
DBA/2J	MGP_DBA2J_G0022610	protein coding gene	Chr16:32494143-32552850 (+)
FVB/NJ	MGP_FVBNJ_G0022585	protein coding gene	Chr16:32489281-32547156 (+)
LP/J	MGP_LPJ_G0022677	protein coding gene	Chr16:34065988-34131025 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022604	protein coding gene	Chr16:35770836-35832667 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023203	protein coding gene	Chr16:33873941-33940370 (+)
PWK/PhJ	MGP_PWKPhJ_G0021776	protein coding gene	Chr16:32911430-32971836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021607	protein coding gene	Chr16:33689168-33740752 (+)
WSB/EiJ	MGP_WSBEiJ_G0022079	protein coding gene	Chr16:33804325-33865131 (+)

Human Ortholog

KPNA1, karyopherin subunit alpha 1

Vertebrate Orthologs

10

Human Ortholog

KPNA1, karyopherin subunit alpha 1
Orthology source: HomoloGene, HGNC
Synonyms

IPOA5, NPI-1, RCH2, SRP1
Links

HGNC:6394

NCBI Gene ID: 3836

neXtProt AC: NX_P52294

UniProt: P52294
Chr Location

3q21.1; chr3:122421901-122514939 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55642
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KPNA1
Protein SuperFamily

Importin_alpha
Gene Tree

Kpna1

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Gene trapped

26
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele do not display any nervous system or behavioral abnormalities.

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All GO Annotations

23
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1048
Tissues

90
cDNA Data

15
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kpna1

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Kpna1 interacts with 461 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

69
RefSeq

6
UniProt

6
CCDS

CCDS28144.1

Ensembl

ENSMUSG00000022905 (Evidence)
NCBI Gene

16646

			Length	Strain/Species	Flank
genomic	16646	NCBI Gene Model \| MGI Sequence Detail	53849	C57BL/6J	± kb
transcript	NM_008465	RefSeq \| MGI Sequence Detail	4022	C57BL/6
polypeptide	Q60960	UniProt \| EBI \| MGI Sequence Detail	538	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009432 importin subunit alpha-5

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR032413 Atypical Arm repeat

IPR002652 Importin-alpha, importin-beta-binding domain

IPR036975 Importin-alpha, importin-beta-binding domain superfamily

IPR024931 Importin subunit alpha

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All nucleic 19

Genomic 1

cDNA 15

Primer pair 3

Microarray probesets 7

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MGD-MRK-24445, MGI:2146643

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 12
Earliest

J:19623 Cortes P, et al., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7
Latest

J:271259 Panayotis N, et al., Importin alpha5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1. Cell Rep. 2018 Dec 11;25(11):3169-3179.e7

TSS for Kpna1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138240	Chr16:35983089-35983106 (+)	-190 bp
Tssr138241	Chr16:35983307-35983395 (+)	63 bp
Tssr138242	Chr16:35983424-35983435 (+)	142 bp
Tssr138244	Chr16:36034937-36034959 (+)	51,660 bp
Tssr138245	Chr16:36035364-36035373 (+)	52,081 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/24/2020 MGI 6.15