Kpna1
Gene Detail

Symbol

Name
ID

Kpna1
karyopherin (importin) alpha 1
MGI:103560

Synonyms

m-importin-alpha-S1, mSRP1, NPI1, Rch2

Feature Type

protein coding gene

Genetic Map

Chromosome 16
25.43 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:35978750-36037131 bp, + strand From VEGA annotation of GRCm38   58382 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:55642  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Importin_alpha
Gene Tree: Kpna1

Human
homologs

Human Homolog		KPNA1, karyopherin alpha 1 (importin alpha 5)
NCBI Gene ID		3836
neXtProt AC		NX_P52294
Human Synonyms		IPOA5, NPI-1, RCH2, SRP1
Human Chr (Location)		3q21; chr3:122421901-122514939 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trap allele do not display any nervous system or behavioral abnormalities.

 

Interactions

Kpna1 interacts with 462 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	positive regulation of protein import into nucleus, protein import into nucleus, ...
Component	cytoplasm, dendrite, ...
Function	protein binding, protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (390)    Tissues (87)    Images (24)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	4
RNA in situ	324
RT-PCR	62

cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000038076 (Evidence)
Ensembl Gene Model	ENSMUSG00000022905 (Evidence)
Entrez Gene	16646 (Evidence)
DFCI	TC1660014, TC1572345
DoTS	DT.91428420, DT.531972, DT.101391425
NIA Mouse Gene Index	U017066
Consensus CDS Project	CCDS28144.1
International Mouse Knockout Project Status	Kpna1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038076	VEGA Gene Model | MGI Sequence Detail	58382	C57BL/6J
transcript	OTTMUST00000098056	VEGA | MGI Sequence Detail	5039	Not Applicable
polypeptide	OTTMUSP00000055030	VEGA | MGI Sequence Detail	538	Not Applicable

All sequences(79) RefSeq(4) UniProt(13)

Polymorphisms

SNPs within 2kb(318 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000225	Armadillo
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR002652	Importin-alpha, importin-beta-binding domain
InterPro	IPR024931	Importin subunit alpha
Protein Ontology	PR:000009432	importin subunit alpha-1

References

(Earliest) J:19623 Cortes P, et al., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7
(Latest) J:185771 Tran MH, et al., Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis. Biol Reprod. 2012 Mar;86(3):84
All references(49)

Other
accession IDs

MGD-MRK-24445, MGI:2146643