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Kpna1
Gene Detail
 Symbol
Name
ID
Kpna1
karyopherin (importin) alpha 1
MGI:103560
Synonyms m-importin-alpha-S1, mSRP1, NPI1, Rch2
Feature Type protein coding gene
Genetic Map
Chromosome 16
25.43 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:35978750-36037131 bp, + strand
From VEGA annotation of GRCm38

  58382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55642  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Importin_alpha
Gene Tree: Kpna1

Human
homologs
Human Homolog KPNA1, karyopherin alpha 1 (importin alpha 5)
NCBI Gene ID 3836
neXtProt AC  NX_P52294
Human Synonyms  IPOA5, NPI-1, RCH2, SRP1
Human Chr (Location)  3q21; chr3:122421901-122514939 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele do not display any nervous system or behavioral abnormalities.
 
Interactions
Kpna1 interacts with 462 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of protein import into nucleus, protein import into nucleus, ...
Component cytoplasm, dendrite, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (390)    Tissues (87)    Images (24)
Theiler Stages: 10, 15, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 324
RT-PCR 62
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000038076 (Evidence)
Ensembl Gene ModelENSMUSG00000022905 (Evidence)
Entrez Gene16646 (Evidence)
DFCITC1572345, TC1660014
DoTSDT.101391425, DT.531972, DT.91428420
NIA Mouse Gene IndexU017066
Consensus CDS ProjectCCDS28144.1
International Mouse Knockout Project StatusKpna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038076 VEGA Gene Model | MGI Sequence Detail 58382 C57BL/6J ±  kb
transcript OTTMUST00000098056 VEGA | MGI Sequence Detail 5039 Not Applicable 
polypeptide OTTMUSP00000055030 VEGA | MGI Sequence Detail 538 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(318 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR002652 Importin-alpha, importin-beta-binding domain
InterPro IPR024931 Importin subunit alpha
Protein Ontology PR:000009432 importin subunit alpha-1
References (Earliest) J:19623 Cortes P, et al., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7
(Latest) J:185771 Tran MH, et al., Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis. Biol Reprod. 2012 Mar;86(3):84
All references(49)
Other
accession IDs
MGD-MRK-24445, MGI:2146643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory