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Xpc
Gene Detail
Symbol

Name
ID
Xpc
xeroderma pigmentosum, complementation group C
MGI:103557
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.55 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:91489305-91515884 bp, - strand
From VEGA annotation of GRCm38

  26580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Xpc

Human
homologs
Human Homolog XPC, xeroderma pigmentosum, complementation group C
NCBI Gene ID 7508
neXtProt AC  NX_Q01831
Human Synonyms  p125, RAD4, XP3, XPCC
Human Chr (Location)  3p25.1; chr3:14145147-14178672 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human XPC
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are highly susceptible to ultraviolet-induced skin tumors and exhibit a 30-fold higher somatic frequency of gene mutations at one year of age. Mutant cells exhibit impaired nucleotide excision repair.
 
Human Diseases Modeled Using Mouse Xpc (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Xpc interacts with 172 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(2) cDNA(53)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024133 (Evidence)
Ensembl Gene ModelENSMUSG00000030094 (Evidence)
Entrez Gene22591 (Evidence)
UniGene2806
DFCITC1577300
DoTSDT.528495, DT.94254077
NIA Mouse Gene IndexU027628
Consensus CDS ProjectCCDS39569.1
International Mouse Knockout Project StatusXpc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024133 VEGA Gene Model | MGI Sequence Detail 26580 C57BL/6J ±  kb
transcript OTTMUST00000059041 VEGA | MGI Sequence Detail 3630 Not Applicable 
polypeptide OTTMUSP00000028684 VEGA | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004583 DNA repair protein Rad4
InterPro IPR018026 DNA repair protein Rad4, subgroup
InterPro IPR018326 Rad4 beta-hairpin domain 1
InterPro IPR018327 Rad4 beta-hairpin domain 2
InterPro IPR018328 Rad4 beta-hairpin domain 3
InterPro IPR018325 Rad4/PNGase transglutaminase-like fold
Protein Ontology PR:000017494 DNA repair protein complementing XP-C cells
References
(Earliest) J:46331 Lynch HT, et al., Xeroderma pigmentosum. Complementation group C and malignant melanoma. Arch Dermatol. 1984 Feb;120(2):175-9
(Latest) J:207379 Ito S, et al., The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells. FEBS Lett. 2014 Apr 2;588(7):1128-35
All references(88)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-24442

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory