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Xpc
Gene Detail
Symbol

Name
ID
Xpc
xeroderma pigmentosum, complementation group C
MGI:103557
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.55 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:91489305-91515884 bp, - strand
From VEGA annotation of GRCm38

  26580 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: XPC
Gene Tree: Xpc

Human
homologs
XPC, xeroderma pigmentosum, complementation group C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7508
neXtProt AC: NX_Q01831

Human Synonyms: p125, RAD4, XP3, XPCC

Human Chr (Location): 3p25.1; chr3:14145147-14178672 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human XPC

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Spontaneous(1) Targeted(4)
Genomic Mutations involving Xpc (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are highly susceptible to ultraviolet-induced skin tumors and exhibit a 30-fold higher somatic frequency of gene mutations at one year of age. Mutant cells exhibit impaired nucleotide excision repair.
 
Human Diseases Modeled in Mice Using Xpc (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Xpc interacts with 171 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, extracellular exosome, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xpc    NEW 
Molecular
reagents
All nucleic(55) Genomic(2) cDNA(53)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024133 (Evidence)
Ensembl Gene Model ENSMUSG00000030094 (Evidence)
Entrez Gene 22591 (Evidence)
UniGene 2806
DFCI TC1577300
DoTS DT.528495, DT.94254077
NIA Mouse Gene Index U027628
Consensus CDS Project CCDS39569.1
International Mouse Phenotyping Consortium Status Xpc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024133 VEGA Gene Model | MGI Sequence Detail 26580 C57BL/6J ±  kb
transcript OTTMUST00000059041 VEGA | MGI Sequence Detail 3630 Not Applicable 
polypeptide OTTMUSP00000028684 VEGA | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004583 DNA repair protein Rad4
InterPro IPR018026 DNA repair protein Rad4, subgroup
InterPro IPR018326 Rad4 beta-hairpin domain 1
InterPro IPR018327 Rad4 beta-hairpin domain 2
InterPro IPR018328 Rad4 beta-hairpin domain 3
InterPro IPR018325 Rad4/PNGase transglutaminase-like fold
Protein Ontology PR:000017494 DNA repair protein complementing XP-C cells
References
(Earliest) J:46331 Lynch HT, et al., Xeroderma pigmentosum. Complementation group C and malignant melanoma. Arch Dermatol. 1984 Feb;120(2):175-9
(Latest) J:220043 Hosseini M, et al., Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice. J Invest Dermatol. 2015 Apr;135(4):1108-18
All references(90)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-24442

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory