Xpc
Gene Detail

Symbol Name ID

Xpc xeroderma pigmentosum, complementation group C MGI:103557

Feature Type

protein coding gene

Genetic Map

Chromosome 6

40.55 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:91489305-91515884 bp, - strand From VEGA annotation of GRCm38   26580 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Xpc

Human homologs

Human Homolog		XPC, xeroderma pigmentosum, complementation group C
NCBI Gene ID		7508
neXtProt AC		NX_Q01831
Human Synonyms		RAD4, XP3, XPCC
Human Chr (Location)		3p25; chr3:14186647-14220172 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human XPC

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous mutants are highly susceptible to ultraviolet-induced skin tumors and exhibit a 30-fold higher somatic frequency of gene mutations at one year of age. Mutant cells exhibit impaired nucleotide excision repair.

 
Human Diseases Modeled Using Mouse Xpc (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell cycle checkpoint, DNA repair, ...
Component	cytoplasm, nucleus, ...
Function	damaged DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(2) cDNA(53)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024133 (Evidence)
Ensembl Gene Model	ENSMUSG00000030094 (Evidence)
Entrez Gene	22591 (Evidence)
UniGene	2806
DFCI	TC1577300
DoTS	DT.528495, DT.94254077
NIA Mouse Gene Index	U027628
Consensus CDS Project	CCDS39569.1
International Mouse Knockout Project Status	Xpc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024133	VEGA Gene Model | MGI Sequence Detail	26580	C57BL/6J
transcript	OTTMUST00000059041	VEGA | MGI Sequence Detail	3630	Not Applicable
polypeptide	OTTMUSP00000028684	VEGA | MGI Sequence Detail	930	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(144 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004583	DNA repair protein Rad4
InterPro	IPR018026	DNA repair protein Rad4, subgroup
InterPro	IPR018326	Rad4 beta-hairpin domain 1
InterPro	IPR018327	Rad4 beta-hairpin domain 2
InterPro	IPR018328	Rad4 beta-hairpin domain 3
InterPro	IPR018325	Rad4/PNGase transglutaminase-like fold
Protein Ontology	PR:000017494	DNA repair protein complementing XP-C cells

References

(Earliest) J:46331 Lynch HT, et al., Xeroderma pigmentosum. Complementation group C and malignant melanoma. Arch Dermatol. 1984 Feb;120(2):175-9
(Latest) J:193203 Melis JP, et al., Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice. Toxicol Appl Pharmacol. 2013 Jan 15;266(2):289-97
All references(85)

Other accession IDs

MGD-MRK-24442