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Cxcl12 Gene Detail
Summary
  • Symbol
    Cxcl12
  • Name
    C-X-C motif chemokine ligand 12
  • Synonyms
    PBSF, PBSF/SDF-1, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b, TLSF-a, TLSF-b, TPAR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103556
    NCBI Gene: 20315
  • Alliance
  • Transcription Start Sites
    55 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:117145496-117158328 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 54.81 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103556
protein coding gene Chr6:117145496-117158329 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031177
protein coding gene Chr6:119868254-119881078 (+)
A/J MGP_AJ_G0031147
protein coding gene Chr6:115264014-115276834 (+)
AKR/J MGP_AKRJ_G0031077
protein coding gene Chr6:118357842-118370666 (+)
BALB/cJ MGP_BALBcJ_G0031157
protein coding gene Chr6:115059791-115072614 (+)
C3H/HeJ MGP_C3HHeJ_G0030552
protein coding gene Chr6:65922611-65935437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031615
protein coding gene Chr6:122914398-122927229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028780
protein coding gene Chr6:112232674-112245529 (+)
CAST/EiJ MGP_CASTEiJ_G0030264
protein coding gene Chr6:118732055-118749718 (+)
CBA/J MGP_CBAJ_G0030841
protein coding gene Chr6:127802285-127815113 (+)
DBA/2J MGP_DBA2J_G0030997
protein coding gene Chr6:114197485-114210307 (+)
FVB/NJ MGP_FVBNJ_G0030949
protein coding gene Chr6:113337261-113350093 (+)
LP/J MGP_LPJ_G0031075
protein coding gene Chr6:119888322-119901147 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030983
protein coding gene Chr6:131912179-131925008 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031644
protein coding gene Chr6:118396570-118409413 (+)
PWK/PhJ MGP_PWKPhJ_G0029980
protein coding gene Chr6:113180796-113198645 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029808
protein coding gene Chr6:117119540-117132395 (+)
WSB/EiJ MGP_WSBEiJ_G0030347
protein coding gene Chr6:118675468-118688328 (+)



Homology
more
  • Human Ortholog
    CXCL12, C-X-C motif chemokine ligand 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL12, C-X-C motif chemokine ligand 12
  • Synonyms
    IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1
  • Links
    NCBI Gene ID: 6387
    neXtProt AC: NX_P48061
    UniProt: P48061

  • Chr Location
    10q11.21; chr10:44370165-44386493 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with human CXCL12 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 9 alleles in 18 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display late embryonic lethality, impaired myelopoiesis, abnormal cerebellum development, abnormal germ cell migration, abnormal angiogenesis around the stomach, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061353 Ensembl Gene Model | MGI Sequence Detail 12833 C57BL/6J ±  kb
    transcript ENSMUST00000073043 Ensembl | MGI Sequence Detail 5627 Not Applicable  
    polypeptide ENSMUSP00000072800 Ensembl | MGI Sequence Detail 119 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 250
      Genomic 2
      cDNA 217
      Primer pair 19
      Other 12

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-16620, MGD-MRK-16621, MGD-MRK-24440, MGI:2141381
    References
    more
    • Summaries
      All 500
      Developmental Gene Expression 171
      Gene Ontology 18
      Phenotypes 148
    • Earliest
      J:17644 Tashiro K, et al., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993 Jul 30;261(5121):600-3
    • Latest
      J:344967 Le VH, et al., CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm. Development. 2024 Jan 15;151(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory