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Cxcl12
Gene Detail
 Symbol
Name
ID
Cxcl12
chemokine (C-X-C motif) ligand 12
MGI:103556
Synonyms PBSF, PBSF/SDF-1, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b, TLSF-a, TLSF-b, TPAR1
Feature Type protein coding gene
Genetic Map
Chromosome 6
54.81 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:117168535-117181367 bp, + strand
From VEGA annotation of GRCm38

  12833 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: CXC chemokine
Gene Tree: Cxcl12

Human
homologs
Human Homolog CXCL12, chemokine (C-X-C motif) ligand 12
NCBI Gene ID 6387
neXtProt AC  NX_P48061
Human Synonyms  IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1
Human Chr (Location)  10q11.1; chr10:44370153-44385097 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CXCL12
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Targeted(13)
 
Homozygous null mice display late embryonic lethality, impaired myelopoiesis, abnormal cerebellum development, abnormal germ cell migration, abnormal angiogenesis around the stomach, and ventricular septal defects.
 
Phenotype Images(2)
Interactions
Cxcl12 interacts with 393 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adult locomotory behavior, ameboidal cell migration, ...
Component external side of plasma membrane, extracellular region, ...
Function chemokine activity, chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (87 records)
Data Summary: Results (647)    Tissues (303)    Images (101)
Theiler Stages: 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 525
Western blot 2
RT-PCR 120
cDNA source data(210)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(220) Genomic(2) cDNA(210) Primer pair(7) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000022768 (Evidence)
Ensembl Gene ModelENSMUSG00000061353 (Evidence)
Entrez Gene20315 (Evidence)
UniGene303231
DFCITC1575734, TC1607385, TC1610196, TC1612258, TC1633641, TC1634864, TC1648517
DoTSDT.536858, DT.60105045, DT.87051055
Consensus CDS ProjectCCDS20463.1, CCDS39605.1, CCDS39606.1
International Mouse Knockout Project StatusCxcl12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022768 VEGA Gene Model | MGI Sequence Detail 12833 C57BL/6J ±  kb
transcript OTTMUST00000054664 VEGA | MGI Sequence Detail 5627 Not Applicable 
polypeptide OTTMUSP00000026114 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(2)
Polymorphisms RFLP(6) : SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000006066 stromal cell-derived factor 1
References (Earliest) J:17644 Tashiro K, et al., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993 Jul 30;261(5121):600-3
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(207)
Other
accession IDs
MGD-MRK-16620, MGD-MRK-16621, MGD-MRK-24440, MGI:2141381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory