Cxcl12
Gene Detail

Symbol Name ID

Cxcl12 chemokine (C-X-C motif) ligand 12 MGI:103556

Synonyms

PBSF, PBSF/SDF-1, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b, TLSF-a, TLSF-b, TPAR1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

54.81 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:117168535-117181367 bp, + strand From VEGA annotation of GRCm38   12833 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:507  Vertebrate Homology Class
1 mouse; 1 rat; 1 chicken

Protein SuperFamily: CXC chemokine
Gene Tree: Cxcl12

Alleles and phenotypes

All alleles(10) : Targeted(9) Gene trapped(1)
 

Homozygous null mice display late embryonic lethality, impaired myelopoiesis, abnormal cerebellum development, abnormal germ cell migration, abnormal angiogenesis around the stomach, and ventricular septal defects.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	adult locomotory behavior, ameboidal cell migration, ...
Component	external side of plasma membrane, extracellular region, ...
Function	chemokine activity, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (80 records)
Data Summary: Results (611)    Tissues (266)    Images (95)
Theiler Stages: 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	489
Western blot	2
RT-PCR	120

cDNA source data(204)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(214) Genomic(2) cDNA(204) Primer pair(7) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000022768 (Evidence)
Ensembl Gene Model	ENSMUSG00000061353 (Evidence)
Entrez Gene	20315 (Evidence)
UniGene	303231
DFCI	TC1575734, TC1607385, TC1610196, TC1612258, TC1633641, TC1634864, TC1648517
DoTS	DT.536858, DT.60105045, DT.87051055
Consensus CDS Project	CCDS20463.1, CCDS39605.1, CCDS39606.1
International Mouse Knockout Project Status	Cxcl12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022768	VEGA Gene Model | MGI Sequence Detail	12833	C57BL/6J
transcript	OTTMUST00000054664	VEGA | MGI Sequence Detail	5627	Not Applicable
polypeptide	OTTMUSP00000026114	VEGA | MGI Sequence Detail	119	Not Applicable

All sequences(60) RefSeq(6) UniProt(2)

Polymorphisms

RFLP(6) : SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001811	Chemokine interleukin-8-like domain
InterPro	IPR002473	CXC chemokine, interleukin 8
Protein Ontology	PR:000006066	stromal cell-derived factor 1

References

(Earliest) J:17644 Tashiro K, et al., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993 Jul 30;261(5121):600-3
(Latest) J:195048 Li W, et al., Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell. 2013 Feb 25;24(4):359-71
All references(186)

Other accession IDs

MGD-MRK-16620, MGD-MRK-16621, MGD-MRK-24440, MGI:2141381