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Cxcl12
Gene Detail
Symbol

Name
ID
Cxcl12
chemokine (C-X-C motif) ligand 12
MGI:103556
Synonyms
PBSF, PBSF/SDF-1, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b, TLSF-a, TLSF-b, TPAR1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
54.81 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:117168535-117181367 bp, + strand
From VEGA annotation of GRCm38

  12833 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CXCL12
Protein SuperFamily: CXC chemokine
Gene Tree: Cxcl12

Human
homologs
CXCL12, chemokine (C-X-C motif) ligand 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6387
neXtProt AC: NX_P48061

Human Synonyms: IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1

Human Chr (Location): 10q11.1; chr10:44370153-44385097 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CXCL12

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Targeted(13)
 
Homozygous null mice display late embryonic lethality, impaired myelopoiesis, abnormal cerebellum development, abnormal germ cell migration, abnormal angiogenesis around the stomach, and ventricular septal defects.
 
Phenotype Images(2)
Interactions
Cxcl12 interacts with 392 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process adult locomotory behavior, ameboidal-type cell migration, ...
Component external side of plasma membrane, extracellular exosome, ...
Function chemokine activity, chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (841)    Tissues (371)    Images (105)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 72
RNA in situ 533
Western blot 2
RT-PCR 234
cDNA source data(211)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CXCL12 ; Xenbase cxcl12 ; ZFIN cxcl12a, cxcl12b    NEW 
Molecular
reagents
All nucleic(225) Genomic(2) cDNA(211) Primer pair(10) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000022768 (Evidence)
Ensembl Gene Model ENSMUSG00000061353 (Evidence)
Entrez Gene 20315 (Evidence)
UniGene 303231
DFCI TC1610196, TC1607385, TC1575734, TC1648517, TC1612258, TC1634864, TC1633641
DoTS DT.87051055, DT.60105045, DT.536858
Consensus CDS Project CCDS20463.1, CCDS39605.1, CCDS39606.1
International Mouse Phenotyping Consortium Status Cxcl12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022768 VEGA Gene Model | MGI Sequence Detail 12833 C57BL/6J ±  kb
transcript OTTMUST00000054664 VEGA | MGI Sequence Detail 5627 Not Applicable 
polypeptide OTTMUSP00000026114 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000006066 stromal cell-derived factor 1
References
(Earliest) J:17644 Tashiro K, et al., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993 Jul 30;261(5121):600-3
(Latest) J:217117 Arranz L, et al., Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 7;512(7512):78-81
All references(213)
Other
accession IDs
MGD-MRK-16620, MGD-MRK-16621, MGD-MRK-24440, MGI:2141381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory