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Cxcl12 Gene Detail
Summary
  • Symbol
    Cxcl12
  • Name
    chemokine (C-X-C motif) ligand 12
  • Synonyms
    PBSF, PBSF/SDF-1, Scyb12, Sdf1, SDF-1, Sdf1a, Sdf1b, TLSF-a, TLSF-b, TPAR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103556
    NCBI Gene: 20315
  • Gene Overview
    MyGene.info: CXCL12
Location & Maps
more
  • Sequence Map
    Chr6:117168535-117181367 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12833 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 54.81 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CXCL12, C-X-C motif chemokine ligand 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXCL12, C-X-C motif chemokine ligand 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1
  • Links
    NCBI Gene ID: 6387
    neXtProt AC: NX_P48061

  • Chr Location
    10q11.1; chr10:44370153-44385097 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CXCL12 associations

Human Disease Mouse Models
       Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 11 alleles in 20 genetic backgrounds
    2 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    1
  • Targeted
    16
  • Transgenic
    1
Homozygous null mice display late embryonic lethality, impaired myelopoiesis, abnormal cerebellum development, abnormal germ cell migration, abnormal angiogenesis around the stomach, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022768 VEGA Gene Model | MGI Sequence Detail 12833 C57BL/6J ±  kb
transcript OTTMUST00000054664 VEGA | MGI Sequence Detail 5627 Not Applicable  
polypeptide OTTMUSP00000026114 VEGA | MGI Sequence Detail 119 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    112 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006066 stromal cell-derived factor 1
  • InterPro Domains
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 227
    Genomic 2
    cDNA 212
    Primer pair 11
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-16620, MGD-MRK-16621, MGD-MRK-24440, MGI:2141381
References
more
  • Summaries
    All 236
    Developmental Gene Expression 101
    Gene Ontology 17
    Phenotypes 60
  • Earliest
    J:17644 Tashiro K, et al., Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993 Jul 30;261(5121):600-3
  • Latest
    J:229448 Tsai HH, et al., Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22;351(6271):379-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory