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Flot2 Gene Detail
Summary
  • Symbol
    Flot2
  • Name
    flotillin 2
  • Synonyms
    Esa, reggie-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103309
    NCBI Gene: 14252
  • Gene Overview
    MyGene.info: FLOT2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78037931-78060434 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103309
protein coding gene Chr11:78037841-78060434 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018761
protein coding gene Chr11:78999919-79024795 (+)
A/J MGP_AJ_G0018727
protein coding gene Chr11:75993594-76016805 (+)
AKR/J MGP_AKRJ_G0018697
protein coding gene Chr11:78299948-78321757 (+)
BALB/cJ MGP_BALBcJ_G0018701
protein coding gene Chr11:76387585-76412611 (+)
C3H/HeJ MGP_C3HHeJ_G0018514
protein coding gene Chr11:78334048-78356950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019152
protein coding gene Chr11:81472276-81495718 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016787
protein coding gene Chr11:72969862-72990181 (+)
CAST/EiJ MGP_CASTEiJ_G0018068
protein coding gene Chr11:78766211-78792614 (+)
CBA/J MGP_CBAJ_G0018484
protein coding gene Chr11:85025171-85050597 (+)
DBA/2J MGP_DBA2J_G0018593
protein coding gene Chr11:75576014-75598373 (+)
FVB/NJ MGP_FVBNJ_G0018583
protein coding gene Chr11:75158280-75182105 (+)
LP/J MGP_LPJ_G0018664
protein coding gene Chr11:79544127-79566957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018609
protein coding gene Chr11:85466596-85489832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019192
protein coding gene Chr11:78536831-78559146 (+)
PWK/PhJ MGP_PWKPhJ_G0017839
protein coding gene Chr11:76351310-76373887 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017630
protein coding gene Chr11:78140676-78164583 (+)
WSB/EiJ MGP_WSBEiJ_G0018121
protein coding gene Chr11:78349077-78372400 (+)



Homology
more
  • Human Ortholog
    FLOT2, flotillin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLOT2, flotillin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECS1, ECS-1, ESA, ESA1, M17S1
  • Links
    NCBI Gene ID: 2319
    neXtProt AC: NX_Q14254
    UniProt: Q14254

  • Chr Location
    17q11.2; chr17:28879339-28897728 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3293
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FLOT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced metastase into the lungs in a breast cancer model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061981 Ensembl Gene Model | MGI Sequence Detail 22504 C57BL/6J ±  kb
transcript ENSMUST00000072289 Ensembl | MGI Sequence Detail 2621 Not Applicable  
polypeptide ENSMUSP00000072136 Ensembl | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 107
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-24193, MGI:2144228
References
more
  • Summaries
    All 63
    Developmental Gene Expression 2
    Gene Ontology 13
    Phenotypes 19
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:263557 Riento K, et al., Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels. PLoS One. 2018;13(5):e0197401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory