About   Help   FAQ
Cacnb3
Gene Detail
Symbol

Name
ID
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
MGI:103307
Synonyms
Beta3, Cchb3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr15:98632220-98644530 bp, + strand
From NCBI annotation of GRCm38

  12311 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Cacnb3

Human
homologs
Human Homolog CACNB3, calcium channel, voltage-dependent, beta 3 subunit
NCBI Gene ID 784
neXtProt AC  NX_P54284
Human Synonyms  CAB3, CACNLB3
Human Chr (Location)  12q13; chr12:48814432-48828943 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Radiation induced(1) Targeted(4)
Genomic Mutations involving Cacnb3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show altered Ca2+ channel activity, hyporesponsiveness to DHP, high blood pressure on a high salt diet, and impaired calcium responses and cytokine production in CD4 T cells. Homozygotes for another null allele show enhanced NMDA activity and long term potentiation.
 
Interactions
Cacnb3 interacts with 186 markers (Mir26a-2, Mir26b, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component apical plasma membrane, membrane, ...
Function calcium channel activity, high voltage-gated calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (153)    Tissues (66)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
RT-PCR 60
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) Genomic(4) cDNA(101) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003352 (Evidence)
Entrez Gene12297 (Evidence)
UniGene3544
DFCITC1576146, TC1608549, TC1633383, TC1702154
DoTSDT.101162275, DT.101204103, DT.101254264, DT.101284081, DT.103564421, DT.492368
NIA Mouse Gene IndexU108305
Consensus CDS ProjectCCDS27800.1, CCDS37192.1
International Mouse Knockout Project StatusCacnb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12297 NCBI Gene Model | MGI Sequence Detail 12311 C57BL/6J ±  kb
transcript NM_007581 RefSeq | MGI Sequence Detail 2822 C57BL/6 
polypeptide P54285 UniProt | EBI | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(30) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunit
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology PR:000004948 voltage-dependent L-type calcium channel subunit beta-3
Graphical View of Protein Domain Structure
References
(Earliest) J:28415 Chin H, et al., Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits. Genomics. 1995 Aug 10;28(3):592-5
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(60)
Other
accession IDs
MGD-MRK-24191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory