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Cacnb3 Gene Detail
Summary
  • Symbol
    Cacnb3
  • Name
    calcium channel, voltage-dependent, beta 3 subunit
  • Synonyms
    Beta3, Cchb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103307
    NCBI Gene: 12297
  • Gene Overview
    MyGene.info: CACNB3
Location & Maps
more
  • Sequence Map
    Chr15:98632220-98644530 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12311 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.64 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CACNB3, calcium voltage-gated channel auxiliary subunit beta 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CACNB3, calcium voltage-gated channel auxiliary subunit beta 3
    Orthology source: HomoloGene
  • Synonyms
    CAB3, CACNLB3
  • Links
    NCBI Gene ID: 784
    neXtProt AC: NX_P54284

  • Chr Location
    12q13; chr12:48814432-48828943 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Cacnb3
  • Incidental Mutations
Homozygotes for a null allele show altered Ca2+ channel activity, hyporesponsiveness to DHP, high blood pressure on a high salt diet, and impaired calcium responses and cytokine production in CD4 T cells. Homozygotes for another null allele show enhancedNMDA activity and long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003352 Ensembl Gene Model | MGI Sequence Detail 12311 C57BL/6J ±  kb
transcript ENSMUST00000003442 Ensembl | MGI Sequence Detail 2819 Not Applicable  
polypeptide ENSMUSP00000003442 Ensembl | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004948 voltage-dependent L-type calcium channel subunit beta-3
  • InterPro Domains
    IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001452 SH3 domain
    IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunit
    IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Molecular
Reagents
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  • All nucleic 109
    Genomic 4
    cDNA 101
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-24191
References
more
  • Summaries
    All 58
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 7
    Phenotypes 37
  • Earliest
    J:28415 Chin H, et al., Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits. Genomics. 1995 Aug 10;28(3):592-5
  • Latest
    J:219845 Dilger EK, et al., Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015 Feb 25;35(8):3652-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory