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Nfatc3
Gene Detail
Symbol

Name
ID
Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
MGI:103296
Synonyms
D8Ertd281e, NFAT4, NFATx
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:106059603-106130537 bp, + strand
From Ensembl annotation of GRCm38

  70935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nfatc3

Human
homologs
Human Homolog NFATC3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NCBI Gene ID 4775
neXtProt AC  NX_Q12968
Human Synonyms  NFAT4, NFATX
Human Chr (Location)  16q22.2; chr16:68085366-68229259 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(49) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Nfatc3 interacts with 410 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular respiration, cellular response to calcium ion, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (210)    Tissues (178)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
RT-PCR 12
cDNA source data(140)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(144) Primer pair(4)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000031902 (Evidence)
Entrez Gene18021 (Evidence)
UniGene383185
DoTSDT.94409379, DT.101737264, DT.101737263, DT.101387568
NIA Mouse Gene IndexU009766
Consensus CDS ProjectCCDS22628.1
International Mouse Knockout Project StatusNfatc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031902 Ensembl Gene Model | MGI Sequence Detail 70935 C57BL/6J ±  kb
transcript ENSMUST00000109308 Ensembl | MGI Sequence Detail 6014 Not Applicable 
polypeptide ENSMUSP00000104931 Ensembl | MGI Sequence Detail 1076 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(19)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011166 nuclear factor of activated T-cells, cytoplasmic 3
References
(Earliest) J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
(Latest) J:205486 Kurabayashi N, et al., Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013 Dec 15;27(24):2708-21
All references(110)
Other
accession IDs
MGD-MRK-24179, MGI:1098734, MGI:2142861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory