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Nfatc3
Gene Detail
Symbol

Name
ID
Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
MGI:103296
Synonyms
D8Ertd281e, NFAT4, NFATx
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:106059603-106130537 bp, + strand
From Ensembl annotation of GRCm38

  70935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFATC3
Gene Tree: Nfatc3

Human
homologs
NFATC3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4775
neXtProt AC: NX_Q12968

Human Synonyms: NFAT4, NFATX

Human Chr (Location): 16q22.2; chr16:68085366-68229259 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(49) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Nfatc3 interacts with 409 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process blood vessel remodeling, calcineurin-NFAT signaling cascade, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (210)    Tissues (178)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
RT-PCR 12
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NFATC3 ; Xenbase nfatc3    NEW 
Molecular
reagents
All nucleic(148) cDNA(144) Primer pair(4)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000031902 (Evidence)
Entrez Gene 18021 (Evidence)
UniGene 383185
DoTS DT.101737263, DT.101387568, DT.94409379, DT.101737264
NIA Mouse Gene Index U009766
Consensus CDS Project CCDS22628.1
International Mouse Phenotyping Consortium Status Nfatc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031902 Ensembl Gene Model | MGI Sequence Detail 70935 C57BL/6J ±  kb
transcript ENSMUST00000109308 Ensembl | MGI Sequence Detail 6014 Not Applicable 
polypeptide ENSMUSP00000104931 Ensembl | MGI Sequence Detail 1076 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(10)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011166 nuclear factor of activated T-cells, cytoplasmic 3
References
(Earliest) J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
(Latest) J:213158 Cho A, et al., Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 2014 Apr 2;82(1):109-24
All references(112)
Other
accession IDs
MGD-MRK-24179, MGI:1098734, MGI:2142861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory