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Nfatc3
Gene Detail
 Symbol
Name
ID
Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
MGI:103296
Synonyms D8Ertd281e, NFAT4, NFATx
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:106059603-106130537 bp, + strand
From NCBI annotation of GRCm38

  70935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nfatc3

Human
homologs
Human Homolog NFATC3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NCBI Gene ID 4775
neXtProt AC  NX_Q12968
Human Synonyms  NFAT4, NFATX
Human Chr (Location)  16q22.2; chr16:68085366-68229259 (+)  GRCh38
Alleles
and
phenotypes
All alleles(56) : Targeted(7) Gene trapped(49)
 
Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular respiration, cellular response to lithium ion, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (210)    Tissues (177)    Images (9)
Theiler Stages: 17, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 198
RT-PCR 12
cDNA source data(140)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(148) cDNA(144) Primer pair(4)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000031902 (Evidence)
Entrez Gene18021 (Evidence)
UniGene383185
DoTSDT.101387568, DT.101737263, DT.101737264, DT.94409379
NIA Mouse Gene IndexU009766
Consensus CDS ProjectCCDS22628.1
International Mouse Knockout Project StatusNfatc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18021 NCBI Gene Model | MGI Sequence Detail 70935 C57BL/6J ±  kb
transcript NM_010901 RefSeq | MGI Sequence Detail 6032 C57BL/6 
polypeptide P97305 UniProt | EBI | MGI Sequence Detail 1075 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(10)
Polymorphisms SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011166 nuclear factor of activated T-cells, cytoplasmic 3
Graphical View of Protein Domain Structure
References (Earliest) J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
(Latest) J:198568 Neria F, et al., NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells. Glia. 2013 Jul;61(7):1052-66
All references(108)
Other
accession IDs
MGD-MRK-24179, MGI:1098734, MGI:2142861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory