Nfatc3
Gene Detail

Symbol Name ID

Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 MGI:103296

Synonyms

D8Ertd281e, NFAT4, NFATx

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr8:106059603-106130537 bp, + strand From NCBI annotation of GRCm38   70935 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:27827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nfatc3

Human homologs

Human Homolog		NFATC3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NCBI Gene ID		4775
neXtProt AC		NX_Q12968
Human Synonyms		NFAT4, NFATX
Human Chr (Location)		16q22.2; chr16:68119269-68263162 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(55) : Targeted(6) Gene trapped(49)
 

Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cellular respiration, cellular response to lithium ion, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (210)    Tissues (177)    Images (9)
Theiler Stages: 17, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	198
RT-PCR	12

cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) cDNA(134) Primer pair(4)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000031902 (Evidence)
Entrez Gene	18021 (Evidence)
UniGene	383185
DoTS	DT.101387568, DT.101737263, DT.101737264, DT.94409379
NIA Mouse Gene Index	U009766
Consensus CDS Project	CCDS22628.1
International Mouse Knockout Project Status	Nfatc3

Sequences

Length	Strain/Species
genomic	18021	NCBI Gene Model | MGI Sequence Detail	70935	C57BL/6J
transcript	NM_010901	RefSeq | MGI Sequence Detail	6032	C57BL/6
polypeptide	P97305	UniProt | EBI | MGI Sequence Detail	1075	Not Applicable

All sequences(49) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR008366	Nuclear factor of activated T cells (NFAT)
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR011539	Rel homology domain
Protein Ontology	PR:000011166	nuclear factor of activated T-cells, cytoplasmic 3

Graphical View of Protein Domain Structure

References

(Earliest) J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
(Latest) J:193870 Phuong TT, et al., Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. 2013 Jan 11;430(2):722-8
All references(105)

Other accession IDs

MGD-MRK-24179, MGI:1098734, MGI:2142861