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Nfatc3 Gene Detail
Summary
  • Symbol
    Nfatc3
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
  • Synonyms
    D8Ertd281e, NFAT4, NFATx
  • Feature Type
    protein coding gene
  • IDs
    MGI:103296
    NCBI Gene: 18021
  • Gene Overview
    MyGene.info: NFATC3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:106058840-106130537 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71698 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.08 cM, cytoband D
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    NFATC3, nuclear factor of activated T cells 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFATC3, nuclear factor of activated T cells 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NFAT4, NFATX
  • Links
    NCBI Gene ID: 4775
    neXtProt AC: NX_Q12968
    UniProt: Q12968

  • Chr Location
    16q22.1; chr16:68085366-68229259 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27827
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NFATC3
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    51 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061942 VEGA Gene Model | MGI Sequence Detail 71698 C57BL/6J ±  kb
    transcript OTTMUST00000151181 VEGA | MGI Sequence Detail 5984 Not Applicable  
    polypeptide OTTMUSP00000078400 VEGA | MGI Sequence Detail 1076 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      163 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain (RHD), DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 144
      Primer pair 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24179, MGI:1098734, MGI:2142861
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 27
      Phenotypes 48
    • Earliest
      J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
    • Latest
      J:251244 Hatem-Vaquero M, et al., Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochim Biophys Acta. 2017 Sep;1860(9):922-935

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory