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Prg2 Gene Detail
Summary
  • Symbol
    Prg2
  • Name
    proteoglycan 2, bone marrow
  • Synonyms
    EMBP, mMBP, mMBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103294
    NCBI Gene: 19074
  • Gene Overview
    MyGene.info: PRG2
Location & Maps
more
  • Sequence Map
    Chr2:84980461-84983632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3172 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMPG, MBP, MBP1, proMBP
  • Links
    NCBI Gene ID: 5553
    neXtProt AC: NX_P13727

  • Chr Location
    11q12; chr11:57386787-57390657 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Prg2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display an essentially normal phenotype although fine structure changes occur in eosinophils.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013454 VEGA Gene Model | MGI Sequence Detail 3172 C57BL/6J ±  kb
transcript OTTMUST00000032528 VEGA | MGI Sequence Detail 838 Not Applicable  
polypeptide OTTMUSP00000014448 VEGA | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 9
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-24176
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:28584 Larson KA, et al., The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol. 1995 Sep 15;155(6):3002-12
  • Latest
    J:229471 Branchfield K, et al., Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory