About   Help   FAQ
Prg2 Gene Detail
Summary
  • Symbol
    Prg2
  • Name
    proteoglycan 2, bone marrow
  • Synonyms
    EMBP, mMBP, mMBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103294
    NCBI Gene: 19074
  • Gene Overview
    MyGene.info: PRG2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84980461-84983632 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103294
protein coding gene Chr2:84980461-84983632 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025917
protein coding gene Chr2:85686621-85689790 (+)
A/J MGP_AJ_G0025891
protein coding gene Chr2:82365239-82368420 (+)
AKR/J MGP_AKRJ_G0025861
protein coding gene Chr2:84496080-84499263 (+)
BALB/cJ MGP_BALBcJ_G0025888
protein coding gene Chr2:82495783-82498964 (+)
C3H/HeJ MGP_C3HHeJ_G0025647
protein coding gene Chr2:84727209-84730392 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026334
protein coding gene Chr2:88341024-88344195 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023736
protein coding gene Chr2:79192406-79195597 (+)
CAST/EiJ MGP_CASTEiJ_G0025108
protein coding gene Chr2:85274125-85277274 (+)
CBA/J MGP_CBAJ_G0025628
protein coding gene Chr2:91492301-91495480 (+)
DBA/2J MGP_DBA2J_G0025759
protein coding gene Chr2:81902299-81905478 (+)
FVB/NJ MGP_FVBNJ_G0025722
protein coding gene Chr2:81157115-81160274 (+)
LP/J MGP_LPJ_G0025847
protein coding gene Chr2:85476786-85479967 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025752
protein coding gene Chr2:93813127-93816296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026390
protein coding gene Chr2:84744044-84747223 (+)
PWK/PhJ MGP_PWKPhJ_G0024852
protein coding gene Chr2:81744881-81749274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024656
protein coding gene Chr2:84864151-84867325 (+)
WSB/EiJ MGP_WSBEiJ_G0025178
protein coding gene Chr2:85399355-85403981 (+)



Homology
more
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMPG, MBP, MBP1, proMBP
  • Links
    NCBI Gene ID: 5553
    neXtProt AC: NX_P13727
    UniProt: P13727

  • Chr Location
    11q12.1; chr11:57386787-57390657 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype although fine structure changes occur in eosinophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19074 NCBI Gene Model | MGI Sequence Detail 3172 C57BL/6J ±  kb
    transcript NM_008920 RefSeq | MGI Sequence Detail 838 C57BL/6  
    polypeptide Q61878 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 9
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24176
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:28584 Larson KA, et al., The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol. 1995 Sep 15;155(6):3002-12
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory