About   Help   FAQ
Rela
Gene Detail
Symbol

Name
ID
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
MGI:103290
Synonyms
p65, p65 NF kappaB
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband B1-3
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:5637483-5648130 bp, + strand
From VEGA annotation of GRCm38

  10648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RELA
Protein SuperFamily: rel-related protein
Gene Tree: Rela

Human
homologs
RELA, v-rel avian reticuloendotheliosis viral oncogene homolog A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5970
neXtProt AC: NX_Q04206

Human Synonyms: NFKB3, p65

Human Chr (Location): 11q13; chr11:65653596-65662972 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are embryonic lethal due to hepatic apoptosis.
 
Interactions
Rela interacts with 80 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (126 annotations)
Process cellular response to hydrogen peroxide, cellular response to interleukin-1, ...
Component cytoplasm, cytosol, ...
Function actinin binding, activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (320)    Tissues (99)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 273
Western blot 21
RT-PCR 17
cDNA source data(141)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rela ; ZFIN rela    NEW 
Molecular
reagents
All nucleic(151) Genomic(5) cDNA(141) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016639 (Evidence)
Ensembl Gene Model ENSMUSG00000024927 (Evidence)
Entrez Gene 19697 (Evidence)
UniGene 249966
DFCI TC1745475, TC1721835, TC1573535
DoTS DT.94285313, DT.535234, DT.101179598
NIA Mouse Gene Index U038712
PDB 1LE9, 2LWW, 1LE5, 2I9T, 1VKX, 1RAM, 1LEI, 1BFT, 1K3Z, 1IKN, 2RAM, 1OY3, 1MY7, 1MY5
Consensus CDS Project CCDS29473.1
International Mouse Phenotyping Consortium Status Rela
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016639 VEGA Gene Model | MGI Sequence Detail 10648 C57BL/6J ±  kb
transcript OTTMUST00000040255 VEGA | MGI Sequence Detail 2716 Not Applicable 
polypeptide OTTMUSP00000017977 VEGA | MGI Sequence Detail 549 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013875 transcription factor p65
References
(Earliest) J:35636 Nolan GP, et al., DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991 Mar 8;64(5):961-9
(Latest) J:221512 Zhao X, et al., alpha-Actinin 4 potentiates nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-kappaB) activity in podocytes independent of its cytoplasmic actin binding function. J Biol Chem. 2015 Jan 2;290(1):338-49
All references(305)
Other
accession IDs
MGD-MRK-24172

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory