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Rela
Gene Detail
 Symbol
Name
ID
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
MGI:103290
Synonyms p65, p65 NF kappaB
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband B1-3
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:5637483-5648130 bp, + strand
From VEGA annotation of GRCm38

  10648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: rel-related protein
Gene Tree: Rela

Human
homologs
Human Homolog RELA, v-rel avian reticuloendotheliosis viral oncogene homolog A
NCBI Gene ID 5970
neXtProt AC  NX_Q04206
Human Synonyms  NFKB3, p65
Human Chr (Location)  11q13; chr11:65653596-65662972 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are embryonic lethal due to hepatic apoptosis.
 
Interactions
Rela interacts with 80 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process cellular response to hydrogen peroxide, cellular response to interleukin-1, ...
Component cytoplasm, cytosol, ...
Function activating transcription factor binding, ankyrin repeat binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (300)    Tissues (91)    Images (36)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 273
RT-PCR 24
cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(151) Genomic(5) cDNA(141) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016639 (Evidence)
Ensembl Gene ModelENSMUSG00000024927 (Evidence)
Entrez Gene19697 (Evidence)
UniGene249966
DFCITC1573535, TC1721835, TC1745475
DoTSDT.101179598, DT.535234, DT.94285313
NIA Mouse Gene IndexU038712
PDB1BFT, 1IKN, 1K3Z, 1LEI, 1RAM, 1VKX, 2I9T, 2LWW, 2RAM, 1LE5, 1LE9, 1MY5, 1MY7, 1OY3
Consensus CDS ProjectCCDS29473.1
International Mouse Knockout Project StatusRela
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016639 VEGA Gene Model | MGI Sequence Detail 10648 C57BL/6J ±  kb
transcript OTTMUST00000040255 VEGA | MGI Sequence Detail 2716 Not Applicable 
polypeptide OTTMUSP00000017977 VEGA | MGI Sequence Detail 549 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000013875 transcription factor p65
References (Earliest) J:35636 Nolan GP, et al., DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991 Mar 8;64(5):961-9
(Latest) J:210175 Du W, et al., Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood. 2014 Mar 20;123(12):1938-47
All references(285)
Other
accession IDs
MGD-MRK-24172

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory