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Polr1c Gene Detail
Summary
  • Symbol
    Polr1c
  • Name
    polymerase (RNA) I polypeptide C
  • Synonyms
    40kDa, RPA40, Rpo1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103288
    NCBI Gene: 20016
  • Gene Overview
    MyGene.info: POLR1C
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46243920-46248045 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103288
protein coding gene Chr17:46243920-46248054 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023807
protein coding gene Chr17:47290358-47294512 (-)
A/J MGP_AJ_G0023765
protein coding gene Chr17:46153846-46157980 (-)
AKR/J MGP_AKRJ_G0023736
protein coding gene Chr17:46488827-46492961 (-)
BALB/cJ MGP_BALBcJ_G0023769
protein coding gene Chr17:46056033-46060167 (-)
C3H/HeJ MGP_C3HHeJ_G0023533
protein coding gene Chr17:47219869-47224003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024212
protein coding gene Chr17:49337937-49342071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021662
protein coding gene Chr17:42956742-42961372 (-)
CAST/EiJ MGP_CASTEiJ_G0023014
protein coding gene Chr17:47343958-47348093 (-)
CBA/J MGP_CBAJ_G0023509
protein coding gene Chr17:51101474-51105608 (-)
DBA/2J MGP_DBA2J_G0023635
protein coding gene Chr17:44943389-44947523 (-)
FVB/NJ MGP_FVBNJ_G0023602
protein coding gene Chr17:44547709-44552223 (-)
LP/J MGP_LPJ_G0023716
protein coding gene Chr17:47968058-47972192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023631
protein coding gene Chr17:50669135-50673276 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024257
protein coding gene Chr17:46841828-46845962 (-)
PWK/PhJ MGP_PWKPhJ_G0022759
protein coding gene Chr17:44260995-44265179 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022574
protein coding gene Chr17:43741554-43745722 (-)
WSB/EiJ MGP_WSBEiJ_G0023079
protein coding gene Chr17:47392047-47396181 (-)



Homology
more
  • Human Ortholog
    POLR1C, RNA polymerase I and III subunit C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POLR1C, RNA polymerase I and III subunit C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AC40, HLD11, RPA39, RPA40, RPA5, RPAC1, RPC40, TCS3
  • Links
    NCBI Gene ID: 9533
    neXtProt AC: NX_O15160
    UniProt: O15160

  • Chr Location
    6p21.1; chr6:43517024-43562404 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human POLR1C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20016 NCBI Gene Model | MGI Sequence Detail 4126 C57BL/6J ±  kb
transcript NM_009085 RefSeq | MGI Sequence Detail 1305 C57BL/6  
polypeptide P52432 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012984 DNA-directed RNA polymerases I and III subunit RPAC1
  • InterPro Domains
    IPR001514 DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
    IPR011262 DNA-directed RNA polymerase, insert domain
    IPR036643 DNA-directed RNA polymerase, insert domain superfamily
    IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type
    IPR033901 DNA-directed RNA polymerases I and III subunit AC40
    IPR036603 RNA polymerase, RBP11-like subunit
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-24170, MGI:2146755, MGI:2146784, MGI:2146961
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:21850 Song CZ, et al., High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. J Biol Chem. 1994 Oct 28;269(43):26976-81
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory