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Polr1c Gene Detail
Summary
  • Symbol
    Polr1c
  • Name
    polymerase (RNA) I polypeptide C
  • Synonyms
    40kDa, RPA40, Rpo1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103288
    NCBI Gene: 20016
  • Gene Overview
    MyGene.info: POLR1C
Location & Maps
more
  • Sequence Map
    Chr17:46243920-46248054 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4135 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    POLR1C, RNA polymerase I subunit C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POLR1C, RNA polymerase I subunit C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AC40, HLD11, RPA39, RPA40, RPA5, RPAC1, RPC40, TCS3
  • Links
    NCBI Gene ID: 9533
    neXtProt AC: NX_O15160

  • Chr Location
    6p21.1; chr6:43517039-43550984 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human POLR1C associations

Human Disease Mouse Models
       Leukodystrophy, Hypomyelinating, 11; HLD11   OMIM: 616494
Treacher Collins Syndrome 3; TCS3   OMIM: 248390
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    19
  • Gene trapped
    17
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028872 VEGA Gene Model | MGI Sequence Detail 4135 C57BL/6J ±  kb
transcript OTTMUST00000071518 VEGA | MGI Sequence Detail 1314 Not Applicable  
polypeptide OTTMUSP00000036652 VEGA | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012984 DNA-directed RNA polymerases I and III subunit RPAC1
  • InterPro Domains
    IPR001514 DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
    IPR011262 DNA-directed RNA polymerase, insert domain
    IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain
    IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Molecular
Reagents
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  • All nucleic 98
    cDNA 98

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-24170, MGI:2146755, MGI:2146784, MGI:2146961
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:21850 Song CZ, et al., High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. J Biol Chem. 1994 Oct 28;269(43):26976-81
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory