Polr1c
Gene Detail

Symbol Name ID

Polr1c polymerase (RNA) I polypeptide C MGI:103288

Synonyms

40kDa, RPA40, Rpo1-1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:46243920-46248054 bp, - strand From VEGA annotation of GRCm38   4135 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3586  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA-directed RNA polymerase 40K chain
Gene Tree: Polr1c

Human homologs

Human Homolog		POLR1C, polymerase (RNA) I polypeptide C, 30kDa
NCBI Gene ID		9533
neXtProt AC		NX_O15160
Human Synonyms		RPA39, RPA40, RPA5, RPAC1, TCS3
Human Chr (Location)		6p21.1; chr6:43484777-43489251 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human POLR1C

Alleles and phenotypes

All alleles(19) : Targeted(2) Gene trapped(17)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	transcription, DNA-dependent
Component	nucleus
Function	DNA binding, DNA-directed RNA polymerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (9)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(98)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(98)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000028872 (Evidence)
Ensembl Gene Model	ENSMUSG00000067148 (Evidence)
Entrez Gene	20016 (Evidence)
UniGene	3458
NIA Mouse Gene Index	U037850
Consensus CDS Project	CCDS37632.1
International Mouse Knockout Project Status	Polr1c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028872	VEGA Gene Model | MGI Sequence Detail	4135	C57BL/6J
transcript	OTTMUST00000071518	VEGA | MGI Sequence Detail	1314	Not Applicable
polypeptide	OTTMUSP00000036652	VEGA | MGI Sequence Detail	346	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001514	DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
InterPro	IPR011261	DNA-directed RNA polymerase, dimerisation
InterPro	IPR011262	DNA-directed RNA polymerase, insert domain
InterPro	IPR009025	DNA-directed RNA polymerase, RBP11-like
InterPro	IPR011263	DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Protein Ontology	PR:000012984	DNA-directed RNA polymerases I and III subunit RPAC1

References

(Earliest) J:21850 Song CZ, et al., High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. J Biol Chem. 1994 Oct 28;269(43):26976-81
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGD-MRK-24170, MGI:2146755, MGI:2146784, MGI:2146961