About   Help   FAQ
Polr1c Gene Detail
Summary
  • Symbol
    Polr1c
  • Name
    polymerase (RNA) I polypeptide C
  • Synonyms
    40kDa, RPA40, Rpo1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103288
    NCBI Gene: 20016
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46554846-46558971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103288
 protein coding gene Chr17:46554846-46558980 (-)
129S1/SvImJ ENSMUSG00200024437
 protein coding gene Chr17:41756047-41760207 (-)
A/J ENSMUSG00195019455
 protein coding gene Chr17:43258136-43262270 (-)
AKR/J ENSMUSG00220034714
 protein coding gene Chr17:42243569-42247703 (-)
BALB/cJ ENSMUSG00180023432
 protein coding gene Chr17:43008373-43012507 (-)
C3H/HeJ ENSMUSG00175013905
 protein coding gene Chr17:42322282-42326416 (-)
C57BL/6NJ ENSMUSG00215031858
 protein coding gene Chr17:41877555-41881689 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021662
 protein coding gene Chr17:42956742-42961372 (-)
CAST/EiJ ENSTCUG00005024850
 protein coding gene Chr17:43055717-43059852 (-)
CBA/J ENSMUSG00210032680
 protein coding gene Chr17:42072011-42076145 (-)
DBA/2J ENSMUSG00185027966
 protein coding gene Chr17:44977374-44981508 (-)
FVB/NJ ENSMUSG00205051725
 protein coding gene Chr17:42549705-42553865 (-)
JF1/MsJ ENSUMUG00000013771
 protein coding gene Chr17:44589441-44593588 (-)
LP/J ENSMUSG00230038648
 protein coding gene Chr17:45871008-45875142 (-)
NOD/ShiLtJ ENSMUSG00190015001
 protein coding gene Chr17:41953329-41957476 (-)
NZO/HlLtJ ENSMUSG00225042107
 protein coding gene Chr17:48126963-48131097 (-)
PWK/PhJ ENSLUMG00010033811
 protein coding gene Chr17:41826115-41830260 (-)
SPRET/EiJ ENSMSPG00010030209
 protein coding gene Chr17:42050953-42054974 (-)
WSB/EiJ ENSIUOG00005023327
 protein coding gene Chr17:42923588-42927722 (-)



Homology
more
  • Human Ortholog
    POLR1C, RNA polymerase I and III subunit C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR1C, RNA polymerase I and III subunit C
  • Synonyms
    AC40, HLD11, RPA39, RPA40, RPA5, RPAC1, RPC40, TCS3
  • Links
    NCBI Gene ID: 9533
    UniProt: O15160

  • Chr Location
    6p21.1; chr6:43509702-43562419 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human POLR1C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    696
  • Tissues
    98
  • cDNA Data
    101
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20016 NCBI Gene Model | MGI Sequence Detail 4126 C57BL/6J ±  kb
    transcript NM_009085 RefSeq | MGI Sequence Detail 1305 C57BL/6  
    polypeptide P52432 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012984 DNA-directed RNA polymerases I and III subunit RPAC1
      (term hierarchy)
    • InterPro Domains
      IPR001514 DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
      IPR011262 DNA-directed RNA polymerase, insert domain
      IPR036643 DNA-directed RNA polymerase, insert domain superfamily
      IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type
      IPR033901 DNA-directed RNA polymerases I and III subunit AC40
      IPR022842 DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
      IPR036603 RNA polymerase, RBP11-like subunit
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 101

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24170, MGI:2146755, MGI:2146784, MGI:2146961
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:21850 Song CZ, et al., High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. J Biol Chem. 1994 Oct 28;269(43):26976-81
    • Latest
      J:381064 Poverennaya I, et al., Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage. Nat Commun. 2026 Mar 9;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory