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Eif4ebp1
Gene Detail
Symbol

Name
ID
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
MGI:103267
Synonyms
4e-bp1, PHAS-I
Feature Type
protein coding gene
Genetic Map
Chromosome 8
15.95 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:27260327-27275656 bp, + strand
From NCBI annotation of GRCm38

  15330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: EIF4EBP1
Protein SuperFamily: eukaryotic translation initiation factor 4E-binding protein
Gene Tree: Eif4ebp1

Human
homologs
EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1978
neXtProt AC: NX_Q13541

Human Synonyms: 4EBP1, 4E-BP1, BP-1, PHAS-I

Human Chr (Location): 8p12; chr8:38030502-38060365 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(43) Targeted(4)
 
Homozygotes for a targeted mutation display hypoglycemia and hypoleptinemia with significantly reduced white fat pads and a notable increase in metabolic rate. Male white adipose tissue exhibits the multilocular appearance of brown adipocytes, and expresses UCP1, a specific marker of brown fat.
 
Interactions
Eif4ebp1 interacts with 116 markers (Mir28b, Mir28c, Mir96, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process G1/S transition of mitotic cell cycle, insulin receptor signaling pathway, ...
Component cytoplasm, cytosol, ...
Function eukaryotic initiation factor 4E binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (60)    Tissues (31)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
cDNA source data(90)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN eif4ebp1    NEW 
Molecular
reagents
All nucleic(91) Genomic(1) cDNA(90)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031490 (Evidence)
Entrez Gene 13685 (Evidence)
UniGene 6700
DFCI TC1575122, TC1761914
DoTS DT.535622, DT.94388500
NIA Mouse Gene Index U009218
Consensus CDS Project CCDS22214.1
International Mouse Phenotyping Consortium Status Eif4ebp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13685 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
transcript NM_007918 RefSeq | MGI Sequence Detail 981 C57BL/6 
polypeptide Q60876 UniProt | EBI | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008606 Eukaryotic translation initiation factor 4E binding
Protein Ontology PR:000006994 eukaryotic translation initiation factor 4E-binding protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:27764 Lin TA, et al., Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 4;270(31):18531-8
(Latest) J:217495 Ka M, et al., mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development. 2014 Nov;141(21):4076-86
All references(84)
Other
accession IDs
MGD-MRK-24146, MGI:2142450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory