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Eif4ebp1
Gene Detail
 Symbol
Name
ID
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
MGI:103267
Synonyms 4e-bp1, PHAS-I
Feature Type protein coding gene
Genetic Map
Chromosome 8
15.95 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:27260327-27275656 bp, + strand
From NCBI annotation of GRCm38

  15330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: eukaryotic translation initiation factor 4E-binding protein
Gene Tree: Eif4ebp1

Human
homologs
Human Homolog EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1
NCBI Gene ID 1978
neXtProt AC  NX_Q13541
Human Synonyms  4EBP1, 4E-BP1, BP-1, PHAS-I
Human Chr (Location)  8p12; chr8:38030502-38060365 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(49) Targeted(4)
 
Homozygotes for a targeted mutation display hypoglycemia and hypoleptinemia with significantly reduced white fat pads and a notable increase in metabolic rate. Male white adipose tissue exhibits the multilocular appearance of brown adipocytes, and expresses UCP1, a specific marker of brown fat.
 
Interactions
Eif4ebp1 interacts with 116 markers (Mir28b, Mir28c, Mir96, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process G1/S transition of mitotic cell cycle, insulin receptor signaling pathway, ...
Component cytoplasm, nucleus, ...
Function eukaryotic initiation factor 4E binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (60)    Tissues (31)    Images (33)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 60
cDNA source data(90)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(1) cDNA(90)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031490 (Evidence)
Entrez Gene13685 (Evidence)
UniGene6700
DFCITC1575122, TC1761914
DoTSDT.535622, DT.94388500
NIA Mouse Gene IndexU009218
Consensus CDS ProjectCCDS22214.1
International Mouse Knockout Project StatusEif4ebp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13685 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
transcript NM_007918 RefSeq | MGI Sequence Detail 981 C57BL/6 
polypeptide Q60876 UniProt | EBI | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008606 Eukaryotic translation initiation factor 4E binding
Protein Ontology PR:000006994 eukaryotic translation initiation factor 4E-binding protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:27764 Lin TA, et al., Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 4;270(31):18531-8
(Latest) J:212082 Lebrun-Julien F, et al., Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. J Neurosci. 2014 Jun 18;34(25):8432-48
All references(76)
Other
accession IDs
MGD-MRK-24146, MGI:2142450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory