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Fgl2
Gene Detail
Symbol

Name
ID
Fgl2
fibrinogen-like protein 2
MGI:103266
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:21372642-21378374 bp, + strand
From VEGA annotation of GRCm38

  5733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGL2
Gene Tree: Fgl2

Human
homologs
FGL2, fibrinogen-like 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10875
neXtProt AC: NX_Q14314

Human Synonyms: pT49, T49

Human Chr (Location): 7q11.23; chr7:77193371-77199833 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolonged survival of heart grafts.
 
Interactions
Fgl2 interacts with 305 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cytolysis
Component extracellular exosome, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (60)    Tissues (22)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 58
RNA in situ 2
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fgl2    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(23) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025650 (Evidence)
Ensembl Gene Model ENSMUSG00000039899 (Evidence)
Entrez Gene 14190 (Evidence)
DFCI TC1578980, TC1722616
DoTS DT.55137452
NIA Mouse Gene Index U005333
Consensus CDS Project CCDS19103.1
International Mouse Phenotyping Consortium Status Fgl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025650 VEGA Gene Model | MGI Sequence Detail 5733 C57BL/6J ±  kb
transcript OTTMUST00000063122 VEGA | MGI Sequence Detail 3788 Not Applicable 
polypeptide OTTMUSP00000031181 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007509 fibroleukin
References
(Earliest) J:29498 Koyama T, et al., Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1609-13
(Latest) J:209951 Joller N, et al., Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17;40(4):569-81
All references(49)
Other
accession IDs
MGD-MRK-24145, MGI:2140850

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory