About   Help   FAQ
Arhgef2 Gene Detail
Summary
  • Symbol
    Arhgef2
  • Name
    rho/rac guanine nucleotide exchange factor (GEF) 2
  • Synonyms
    GEFH1, GEF-H1, Lbcl1, Lfc, LFP40, mKIAA0651, P40
  • Feature Type
    protein coding gene
  • IDs
    MGI:103264
    NCBI Gene: 16800
  • Gene Overview
    MyGene.info: ARHGEF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:88605966-88648052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42087 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.90 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF, GEFH1, GEF-H1, LFP40, NEDMHM, P40
  • Links
    NCBI Gene ID: 9181
    neXtProt AC: NX_Q92974
    UniProt: Q92974

  • Chr Location
    1q22; chr1:155946839-155991263 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit impaired response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042225 VEGA Gene Model | MGI Sequence Detail 42087 C57BL/6J ±  kb
    transcript OTTMUST00000110919 VEGA | MGI Sequence Detail 4300 Not Applicable  
    polypeptide OTTMUSP00000061968 VEGA | MGI Sequence Detail 985 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      281 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24143, MGI:2139563
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:27762 Whitehead I, et al., Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J Biol Chem. 1995 Aug 4;270(31):18388-95
    • Latest
      J:242973 Ravindran E, et al., Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation. PLoS Genet. 2017 Apr;13(4):e1006746

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory