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Arhgef2 Gene Detail
Summary
  • Symbol
    Arhgef2
  • Name
    rho/rac guanine nucleotide exchange factor (GEF) 2
  • Synonyms
    GEFH1, GEF-H1, Lbcl1, Lfc, LFP40, mKIAA0651, P40
  • Feature Type
    protein coding gene
  • IDs
    MGI:103264
    NCBI Gene: 16800
  • Gene Overview
    MyGene.info: ARHGEF2
Location & Maps
more
  • Sequence Map
    Chr3:88607454-88648052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40599 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.90 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF, GEFH1, GEF-H1, LFP40, P40
  • Links
    NCBI Gene ID: 9181
    neXtProt AC: NX_Q92974

  • Chr Location
    1q21-q22; chr1:155946640-156002635 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    44
  • Chemically induced (other)
    1
  • Gene trapped
    40
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Arhgef2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit impaired response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042225 VEGA Gene Model | MGI Sequence Detail 40599 C57BL/6J ±  kb
transcript OTTMUST00000110919 VEGA | MGI Sequence Detail 4300 Not Applicable  
polypeptide OTTMUSP00000061968 VEGA | MGI Sequence Detail 985 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    281 from dbSNP Build 142
Protein
Information
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  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000004255 rho guanine nucleotide exchange factor 2
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-24143, MGI:2139563
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:27762 Whitehead I, et al., Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J Biol Chem. 1995 Aug 4;270(31):18388-95
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory