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Adad1
Gene Detail
 Symbol
Name
ID
Adad1
adenosine deaminase domain containing 1 (testis specific)
MGI:103258
Feature Type protein coding gene
Genetic Map
Chromosome 3
18.30 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:37063527-37121924 bp, + strand
From VEGA annotation of GRCm38

  58398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Adad1

Human
homologs
Human Homolog ADAD1, adenosine deaminase domain containing 1 (testis-specific)
NCBI Gene ID 132612
neXtProt AC  NX_Q96M93
Human Synonyms  Tenr
Human Chr (Location)  4q27; chr4:122378966-122429802 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a mutated allele have reduced sperm counts and motility, and increased sperm malformation resulting in background dependent sterility.
 
Interactions
Adad1 interacts with 205 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function adenosine deaminase activity, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (48)    Tissues (42)    Images (7)
Theiler Stages: 21, 23, 27
Assay TypeResults
RNA in situ 46
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006613 (Evidence)
Ensembl Gene ModelENSMUSG00000027719 (Evidence)
Entrez Gene21744 (Evidence)
UniGene8122
DFCITC1585203
DoTSDT.60110181
NIA Mouse Gene IndexU003168
Consensus CDS ProjectCCDS17315.1
International Mouse Knockout Project StatusAdad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006613 VEGA Gene Model | MGI Sequence Detail 58398 C57BL/6J ±  kb
transcript OTTMUST00000015079 VEGA | MGI Sequence Detail 3101 Not Applicable 
polypeptide OTTMUSP00000006971 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(20) UniProt(3)
Polymorphisms SNPs within 2kb(566 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002466 Adenosine deaminase/editase
InterPro IPR014720 Double-stranded RNA-binding-like domain
Protein Ontology PR:000003708 adenosine deaminase domain-containing protein 1
References (Earliest) J:26660 Schumacher JM, et al., Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Biol Reprod. 1995 Jun;52(6):1274-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)
Other
accession IDs
MGD-MRK-24134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory