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Adad1
Gene Detail
Symbol

Name
ID
Adad1
adenosine deaminase domain containing 1 (testis specific)
MGI:103258
Feature Type
protein coding gene
Genetic Map
Chromosome 3
18.30 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:37063527-37121924 bp, + strand
From VEGA annotation of GRCm38

  58398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7569  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAD1
Gene Tree: Adad1

Human
homologs
ADAD1, adenosine deaminase domain containing 1 (testis-specific)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 132612
neXtProt AC: NX_Q96M93

Human Synonyms: Tenr

Human Chr (Location): 4q27; chr4:122378966-122429815 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Endonuclease-mediated(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a mutated allele have reduced sperm counts and motility, and increased sperm malformation resulting in background dependent sterility.
 
Interactions
Adad1 interacts with 205 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function adenosine deaminase activity, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (40)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
RT-PCR 2
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adad1    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006613 (Evidence)
Ensembl Gene Model ENSMUSG00000027719 (Evidence)
Entrez Gene 21744 (Evidence)
UniGene 8122
DFCI TC1585203
DoTS DT.60110181
NIA Mouse Gene Index U003168
Consensus CDS Project CCDS17315.1
International Mouse Phenotyping Consortium Status Adad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006613 VEGA Gene Model | MGI Sequence Detail 58398 C57BL/6J ±  kb
transcript OTTMUST00000015079 VEGA | MGI Sequence Detail 3101 Not Applicable 
polypeptide OTTMUSP00000006971 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(566 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002466 Adenosine deaminase/editase
InterPro IPR014720 Double-stranded RNA-binding-like domain
Protein Ontology PR:000003708 adenosine deaminase domain-containing protein 1
References
(Earliest) J:26660 Schumacher JM, et al., Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Biol Reprod. 1995 Jun;52(6):1274-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Other
accession IDs
MGD-MRK-24134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory