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Inpp5b
Gene Detail
 Symbol
Name
ID
Inpp5b
inositol polyphosphate-5-phosphatase B
MGI:103257
Synonyms 75kDa
Feature Type protein coding gene
Genetic Map
Chromosome 4
57.89 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:124741850-124801511 bp, + strand
From VEGA annotation of GRCm38

  59662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Inpp5b

Human
homologs
Human Homolog INPP5B, inositol polyphosphate-5-phosphatase, 75kDa
NCBI Gene ID 3633
neXtProt AC  NX_P32019
Human Synonyms  5PTase
Human Chr (Location)  1p34; chr1:37860697-37947057 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(18) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Inpp5b interacts with 171 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process dephosphorylation, in utero embryonic development, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function hydrolase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (109)    Images (25)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 114
Northern blot 12
RT-PCR 15
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(97) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009176 (Evidence)
Ensembl Gene ModelENSMUSG00000028894 (Evidence)
Entrez Gene16330 (Evidence)
UniGene296202
DFCITC1576011, TC1593124, TC1773788
DoTSDT.101382175, DT.101382177, DT.110805768, DT.110805773, DT.491307, DT.94400240
NIA Mouse Gene IndexU004789
EC3.1.3.36
PDB2KIG
Consensus CDS ProjectCCDS38876.1
International Mouse Knockout Project StatusInpp5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009176 VEGA Gene Model | MGI Sequence Detail 59662 C57BL/6J ±  kb
transcript OTTMUST00000020749 VEGA | MGI Sequence Detail 3809 Not Applicable 
polypeptide OTTMUSP00000009518 VEGA | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(16) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000009048 type II inositol 1,4,5-trisphosphate 5-phosphatase
References (Earliest) J:17529 Janne PA, et al., Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. Cytogenet Cell Genet. 1994;66(3):164-6
(Latest) J:185879 Bothwell SP, et al., Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy. J Am Soc Nephrol. 2011 Mar;22(3):443-8
All references(48)
Other
accession IDs
MGD-MRK-24133, MGI:2140565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory