Inpp5b
Gene Detail

Symbol Name ID

Inpp5b inositol polyphosphate-5-phosphatase B MGI:103257

Synonyms

75kDa

Feature Type

protein coding gene

Genetic Map

Chromosome 4

57.89 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:124741850-124801511 bp, + strand From VEGA annotation of GRCm38   59662 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Inpp5b

Human homologs

Human Homolog		INPP5B, inositol polyphosphate-5-phosphatase, 75kDa
NCBI Gene ID		3633
neXtProt AC		NX_P32019
Human Synonyms		5PTase
Human Chr (Location)		1p34; chr1:38326369-38412729 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(6) Gene trapped(18)
 

Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	dephosphorylation, in utero embryonic development, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	hydrolase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (109)    Images (25)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	114
Northern blot	12
RT-PCR	15

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(100) Genomic(1) cDNA(97) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009176 (Evidence)
Ensembl Gene Model	ENSMUSG00000028894 (Evidence)
Entrez Gene	16330 (Evidence)
UniGene	296202
DFCI	TC1576011, TC1593124, TC1773788
DoTS	DT.101382175, DT.101382177, DT.110805768, DT.110805773, DT.491307, DT.94400240
NIA Mouse Gene Index	U004789
EC	3.1.3.36
PDB	2KIG
Consensus CDS Project	CCDS38876.1
International Mouse Knockout Project Status	Inpp5b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009176	VEGA Gene Model | MGI Sequence Detail	59662	C57BL/6J
transcript	OTTMUST00000020749	VEGA | MGI Sequence Detail	3809	Not Applicable
polypeptide	OTTMUSP00000009518	VEGA | MGI Sequence Detail	993	Not Applicable

All sequences(53) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(375 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
InterPro	IPR000300	Inositol polyphosphate-related phosphatase
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000009048	type II inositol-1,4,5-trisphosphate 5-phosphatase

References

(Earliest) J:17529 Janne PA, et al., Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. Cytogenet Cell Genet. 1994;66(3):164-6
(Latest) J:185879 Bothwell SP, et al., Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy. J Am Soc Nephrol. 2011 Mar;22(3):443-8
All references(48)

Other accession IDs

MGD-MRK-24133, MGI:2140565