Inpp5b MGI Mouse Gene Detail - MGI:103257 - inositol polyphosphate-5-phosphatase B

Symbol

Inpp5b
Name

inositol polyphosphate-5-phosphatase B
Synonyms

75kDa

Feature Type

protein coding gene
IDs

MGI:103257
NCBI Gene: 16330
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:124635643-124695304 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 57.89 cM, cytoband D2
Mapping Data

6 experiments

SNPs within 2kb

415 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103257	protein coding gene	Chr4:124635620-124695304 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028753	protein coding gene	Chr4:126288037-126354997 (+)
A/J	MGP_AJ_G0028712	protein coding gene	Chr4:121338272-121397252 (+)
AKR/J	MGP_AKRJ_G0028665	protein coding gene	Chr4:124643420-124714561 (+)
BALB/cJ	MGP_BALBcJ_G0028735	protein coding gene	Chr4:121913612-121973225 (+)
C3H/HeJ	MGP_C3HHeJ_G0028449	protein coding gene	Chr4:124746610-124811078 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029177	protein coding gene	Chr4:131160570-131220831 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026450	protein coding gene	Chr4:114510095-114572864 (+)
CAST/EiJ	MGP_CASTEiJ_G0027882	protein coding gene	Chr4:122804713-122868132 (+)
CBA/J	MGP_CBAJ_G0028415	protein coding gene	Chr4:134412310-134477281 (+)
DBA/2J	MGP_DBA2J_G0028564	protein coding gene	Chr4:121815390-121875150 (+)
FVB/NJ	MGP_FVBNJ_G0028531	protein coding gene	Chr4:120438153-120500955 (+)
LP/J	MGP_LPJ_G0028665	protein coding gene	Chr4:126592952-126654361 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028557	protein coding gene	Chr4:139413663-139475248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029215	protein coding gene	Chr4:125020604-125084229 (+)
PWK/PhJ	MGP_PWKPhJ_G0027603	protein coding gene	Chr4:118228740-118293624 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027429	protein coding gene	Chr4:120793531-120855832 (+)
WSB/EiJ	MGP_WSBEiJ_G0027962	protein coding gene	Chr4:125094907-125157588 (+)

Human Ortholog

INPP5B, inositol polyphosphate-5-phosphatase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INPP5B, inositol polyphosphate-5-phosphatase B
Synonyms

5PTase
Links

HGNC:6077

NCBI Gene ID: 3633

neXtProt AC: NX_P32019

UniProt: P32019
Chr Location

1p34.3; chr1:37860697-37947057 (-) GRCh38

MGI Vertebrate Homology

Inpp5b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INPP5B
Gene Tree

Inpp5b

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 3 alleles in 4 genetic backgrounds
9 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

2
Gene trapped

11
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Inpp5b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

109
cDNA Data

97
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inpp5b

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All Sequences

69
RefSeq

8
UniProt

5
CCDS

CCDS38876.1

Ensembl

ENSMUSG00000028894 (Evidence)
NCBI Gene

16330

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028894	Ensembl Gene Model \| MGI Sequence Detail	59662	C57BL/6J	± kb
transcript	ENSMUST00000094782	Ensembl \| MGI Sequence Detail	3809	Not Applicable
polypeptide	ENSMUSP00000092375	Ensembl \| MGI Sequence Detail	993	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009048 type II inositol 1,4,5-trisphosphate 5-phosphatase

(term hierarchy)
PDB

2KIG
EC

3.1.3.36
InterPro Domains

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR013783 Immunoglobulin-like fold

IPR046985 Inositol 5-phosphatase

IPR047078 Inositol polyphosphate 5-phosphatase OCRL, RhoGAP

IPR000300 Inositol polyphosphate-related phosphatase

IPR031896 INPP5B, PH domain

IPR048869 OCRL-1/2, ASH domain

IPR037793 OCRL1/INPP5B, INPP5c domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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All nucleic 101

Genomic 1

cDNA 98

Primer pair 2

Microarray probesets 4

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MGD-MRK-24133, MGI:2140565

Summaries

All 57

Developmental Gene Expression 5

Diseases 1

Gene Ontology 8

Phenotypes 20
Earliest

J:17529 Janne PA, et al., Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. Cytogenet Cell Genet. 1994;66(3):164-6
Latest

J:336347 Wang B, et al., OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Rep. 2021 May 13;:e52173

TSS for Inpp5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38909	Chr4:124635637-124635677 (+)	14 bp
Tssr38912	Chr4:124645388-124645397 (+)	9,750 bp
Tssr38913	Chr4:124645401-124645442 (+)	9,779 bp
Tssr38914	Chr4:124685204-124685210 (+)	49,564 bp
Tssr38915	Chr4:124685215-124685245 (+)	49,587 bp
Tssr38916	Chr4:124692641-124692655 (+)	57,005 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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