About   Help   FAQ
Inpp5b
Gene Detail
Symbol

Name
ID
Inpp5b
inositol polyphosphate-5-phosphatase B
MGI:103257
Synonyms
75kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.89 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:124741850-124801511 bp, + strand
From VEGA annotation of GRCm38

  59662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: INPP5B
Gene Tree: Inpp5b

Human
homologs
INPP5B, inositol polyphosphate-5-phosphatase, 75kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3633
neXtProt AC: NX_P32019

Human Synonyms: 5PTase

Human Chr (Location): 1p34; chr1:37860697-37947084 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(18) Targeted(7) Transgenic(1)
Genomic Mutations involving Inpp5b (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Inpp5b interacts with 171 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (141)    Tissues (109)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 114
Northern blot 12
RT-PCR 15
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase inpp5b    NEW 
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(97) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009176 (Evidence)
Ensembl Gene Model ENSMUSG00000028894 (Evidence)
Entrez Gene 16330 (Evidence)
UniGene 296202
DFCI TC1576011, TC1593124, TC1773788
DoTS DT.101382175, DT.101382177, DT.110805768, DT.110805770, DT.110805773, DT.40158236, DT.491307, DT.94339132, DT.94400240
NIA Mouse Gene Index U004789
EC 3.1.3.36
PDB 2KIG
Consensus CDS Project CCDS38876.1
International Mouse Phenotyping Consortium Status Inpp5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009176 VEGA Gene Model | MGI Sequence Detail 59662 C57BL/6J ±  kb
transcript OTTMUST00000020749 VEGA | MGI Sequence Detail 3809 Not Applicable 
polypeptide OTTMUSP00000009518 VEGA | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(15) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(415 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000009048 type II inositol 1,4,5-trisphosphate 5-phosphatase
References
(Earliest) J:17529 Janne PA, et al., Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. Cytogenet Cell Genet. 1994;66(3):164-6
(Latest) J:185879 Bothwell SP, et al., Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy. J Am Soc Nephrol. 2011 Mar;22(3):443-8
All references(47)
Other
accession IDs
MGD-MRK-24133, MGI:2140565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory