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Acly Gene Detail
Summary
  • Symbol
    Acly
  • Name
    ATP citrate lyase
  • Synonyms
    A730098H14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103251
    NCBI Gene: 104112
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:100476353-100528000 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51648 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACLY, ATP citrate lyase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACLY, ATP citrate lyase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACL, ATPCL, CLATP
  • Links
    NCBI Gene ID: 47
    neXtProt AC: NX_P53396
    UniProt: P53396

  • Chr Location
    17q21.2; chr17:41866916-41930542 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 854
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACLY
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006279 VEGA Gene Model | MGI Sequence Detail 51648 C57BL/6J ±  kb
transcript OTTMUST00000048853 VEGA | MGI Sequence Detail 4426 Not Applicable  
polypeptide OTTMUSP00000022507 VEGA | MGI Sequence Detail 1101 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    266 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR005811 ATP-citrate lyase/succinyl-CoA ligase
    IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
    IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site
    IPR014608 ATP-citrate synthase
    IPR032263 ATP-citrate synthase, citrate-binding domain
    IPR013815 ATP-grasp fold, subdomain 1
    IPR002020 Citrate synthase
    IPR016142 Citrate synthase-like, large alpha subdomain
    IPR016143 Citrate synthase-like, small alpha subdomain
    IPR036969 Citrate synthase superfamily
    IPR003781 CoA-binding
    IPR036291 NAD(P)-binding domain superfamily
    IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
    IPR016102 Succinyl-CoA synthetase-like
Molecular
Reagents
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  • All nucleic 24
    cDNA 20
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-24127, MGI:2144554, MGI:2443004
References
more
  • Summaries
    All 66
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory