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Acly
Gene Detail
 Symbol
Name
ID
Acly
ATP citrate lyase
MGI:103251
Synonyms A730098H14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:100476353-100528000 bp, - strand
From VEGA annotation of GRCm38

  51648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:854  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acly

Human
homologs
Human Homolog ACLY, ATP citrate lyase
NCBI Gene ID 47
neXtProt AC  NX_P53396
Human Synonyms  ACL, ATPCL, CLATP
Human Chr (Location)  17q21.2; chr17:41866916-41930542 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(35) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
 
Interactions
Acly interacts with 188 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process acetyl-CoA biosynthetic process, acetyl-CoA metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function ATP binding, ATP citrate synthase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (312)    Tissues (119)    Images (56)
Theiler Stages: 17, 22, 23, 24, 26
Assay TypeResults
RNA in situ 309
Western blot 3
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000006279 (Evidence)
Ensembl Gene ModelENSMUSG00000020917 (Evidence)
Entrez Gene104112 (Evidence)
DFCITC1573874, TC1593128, TC1598719, TC1748953
DoTSDT.102558055, DT.103580498, DT.536115, DT.55134562, DT.91442101, DT.94197479, DT.97332356, DT.97338016, DT.97346544
NIA Mouse Gene IndexU033427
EC2.3.3.8
Consensus CDS ProjectCCDS25425.1, CCDS56807.1
International Mouse Knockout Project StatusAcly
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006279 VEGA Gene Model | MGI Sequence Detail 51648 C57BL/6J ±  kb
transcript OTTMUST00000048853 VEGA | MGI Sequence Detail 4426 Not Applicable 
polypeptide OTTMUSP00000022507 VEGA | MGI Sequence Detail 1101 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(9)
Polymorphisms SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005811 ATP-citrate lyase/succinyl-CoA ligase
InterPro IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
InterPro IPR014608 ATP-citrate synthase
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
InterPro IPR002020 Citrate synthase-like
InterPro IPR016141 Citrate synthase-like, core
InterPro IPR016142 Citrate synthase-like, large alpha subdomain
InterPro IPR016143 Citrate synthase-like, small alpha subdomain
InterPro IPR003781 CoA-binding
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR005810 Succinyl-CoA ligase, alpha subunit
InterPro IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
InterPro IPR016102 Succinyl-CoA synthetase-like
Protein Ontology PR:000003628 ATP-citrate synthase
References (Earliest) J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
(Latest) J:190090 Hasegawa S, et al., Acetoacetyl-CoA synthetase is essential for normal neuronal development. Biochem Biophys Res Commun. 2012 Oct 19;427(2):398-403
All references(49)
Other
accession IDs
MGD-MRK-24127, MGI:2144554, MGI:2443004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory