Acly
Gene Detail

Symbol Name ID

Acly ATP citrate lyase MGI:103251

Synonyms

A730098H14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:100476353-100528000 bp, - strand From VEGA annotation of GRCm38   51648 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:854  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Acly

Human homologs

Human Homolog		ACLY, ATP citrate lyase
NCBI Gene ID		47
neXtProt AC		NX_P53396
Human Synonyms		ACL, ATPCL, CLATP
Human Chr (Location)		17q21.2; chr17:40023179-40075272 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(37) : Targeted(1) Gene trapped(35) Transgenic(1)
 

Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	acetyl-CoA biosynthetic process, acetyl-CoA metabolic process, ...
Component	cytoplasm, intracellular, ...
Function	ATP binding, ATP citrate synthase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (312)    Tissues (119)    Images (56)
Theiler Stages: 17, 22, 23, 24, 26

Assay Type	Results
RNA in situ	309
Western blot	3

cDNA source data(559)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(562) cDNA(560) Primer pair(1) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000006279 (Evidence)
Ensembl Gene Model	ENSMUSG00000020917 (Evidence)
Entrez Gene	104112 (Evidence)
UniGene	282039
DFCI	TC1573874, TC1593128, TC1598719, TC1748953
DoTS	DT.102558055, DT.103580498, DT.536115, DT.55134562, DT.91442101, DT.94197479, DT.97332356, DT.97338016, DT.97346544
NIA Mouse Gene Index	U033427
EC	2.3.3.8
Consensus CDS Project	CCDS25425.1, CCDS56807.1
International Mouse Knockout Project Status	Acly

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006279	VEGA Gene Model | MGI Sequence Detail	51648	C57BL/6J
transcript	OTTMUST00000048853	VEGA | MGI Sequence Detail	4426	Not Applicable
polypeptide	OTTMUSP00000022507	VEGA | MGI Sequence Detail	1101	Not Applicable

All sequences(74) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(180 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005811	ATP-citrate lyase/succinyl-CoA ligase
InterPro	IPR017440	ATP-citrate lyase/succinyl-CoA ligase, active site
InterPro	IPR014608	ATP-citrate synthase
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR013650	ATP-grasp fold, succinyl-CoA synthetase-type
InterPro	IPR002020	Citrate synthase-like
InterPro	IPR016141	Citrate synthase-like, core
InterPro	IPR016142	Citrate synthase-like, large alpha subdomain
InterPro	IPR016143	Citrate synthase-like, small alpha subdomain
InterPro	IPR003781	CoA-binding
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR005810	Succinyl-CoA ligase, alpha subunit
InterPro	IPR017866	Succinyl-CoA synthetase, beta subunit, conserved site
InterPro	IPR016102	Succinyl-CoA synthetase-like
Protein Ontology	PR:000003628	ATP-citrate synthase

References

(Earliest) J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
(Latest) J:190090 Hasegawa S, et al., Acetoacetyl-CoA synthetase is essential for normal neuronal development. Biochem Biophys Res Commun. 2012 Oct 19;427(2):398-403
All references(50)

Other accession IDs

MGD-MRK-24127, MGI:2144554, MGI:2443004