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Acly
Gene Detail
Symbol

Name
ID
Acly
ATP citrate lyase
MGI:103251
Synonyms
A730098H14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:100476353-100528000 bp, - strand
From VEGA annotation of GRCm38

  51648 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:854  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACLY
Gene Tree: Acly

Human
homologs
ACLY, ATP citrate lyase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 47
neXtProt AC: NX_P53396

Human Synonyms: ACL, ATPCL, CLATP

Human Chr (Location): 17q21.2; chr17:41866916-41930542 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(2) Transgenic(1)
Genomic Mutations involving Acly (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
 
Interactions
Acly interacts with 188 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process acetyl-CoA biosynthetic process, acetyl-CoA metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function ATP binding, ATP citrate synthase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (312)    Tissues (119)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 309
Western blot 3
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acly ; ZFIN aclya    NEW 
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000006279 (Evidence)
Ensembl Gene Model ENSMUSG00000020917 (Evidence)
Entrez Gene 104112 (Evidence)
DFCI TC1573874, TC1598719, TC1593128, TC1748953
DoTS DT.103580498, DT.102558055, DT.91442101, DT.55134562, DT.536115, DT.97346544, DT.94197479, DT.97338016, DT.97332356
NIA Mouse Gene Index U033427
EC 2.3.3.8
Consensus CDS Project CCDS25425.1, CCDS56807.1
International Mouse Phenotyping Consortium Status Acly
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006279 VEGA Gene Model | MGI Sequence Detail 51648 C57BL/6J ±  kb
transcript OTTMUST00000048853 VEGA | MGI Sequence Detail 4426 Not Applicable 
polypeptide OTTMUSP00000022507 VEGA | MGI Sequence Detail 1101 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005811 ATP-citrate lyase/succinyl-CoA ligase
InterPro IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
InterPro IPR014608 ATP-citrate synthase
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
InterPro IPR002020 Citrate synthase-like
InterPro IPR016141 Citrate synthase-like, core
InterPro IPR016142 Citrate synthase-like, large alpha subdomain
InterPro IPR016143 Citrate synthase-like, small alpha subdomain
InterPro IPR003781 CoA-binding
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR005810 Succinyl-CoA ligase, alpha subunit
InterPro IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
InterPro IPR016102 Succinyl-CoA synthetase-like
Protein Ontology PR:000003628 ATP-citrate synthase
References
(Earliest) J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
(Latest) J:213234 Cho HH, et al., Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet. 2014 Apr;10(4):e1004280
All references(49)
Other
accession IDs
MGD-MRK-24127, MGI:2144554, MGI:2443004

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory