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Acly Gene Detail
Summary
  • Symbol
    Acly
  • Name
    ATP citrate lyase
  • Synonyms
    A730098H14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103251
    NCBI Gene: 104112
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100367179-100418826 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103251
protein coding gene Chr11:100367178-100418826 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019158
protein coding gene Chr11:103237693-103289076 (-)
A/J MGP_AJ_G0019126
protein coding gene Chr11:98926708-98978204 (-)
AKR/J MGP_AKRJ_G0019095
protein coding gene Chr11:101976004-102032418 (-)
BALB/cJ MGP_BALBcJ_G0019100
protein coding gene Chr11:99405610-99457341 (-)
C3H/HeJ MGP_C3HHeJ_G0018909
protein coding gene Chr11:102172502-102223816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019549
protein coding gene Chr11:106448583-106501656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017175
protein coding gene Chr11:96345284-96397268 (-)
CAST/EiJ MGP_CASTEiJ_G0018463
protein coding gene Chr11:103151502-103202530 (-)
CBA/J MGP_CBAJ_G0018878
protein coding gene Chr11:110876622-110930853 (-)
DBA/2J MGP_DBA2J_G0018990
protein coding gene Chr11:98465071-98516394 (-)
FVB/NJ MGP_FVBNJ_G0018980
protein coding gene Chr11:97998138-98050605 (-)
LP/J MGP_LPJ_G0019059
protein coding gene Chr11:103789800-103843609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019011
protein coding gene Chr11:110482216-110535038 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019587
protein coding gene Chr11:102319880-102371276 (-)
PWK/PhJ MGP_PWKPhJ_G0018226
protein coding gene Chr11:99503290-99555165 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018018
protein coding gene Chr11:102040459-102089605 (-)
WSB/EiJ MGP_WSBEiJ_G0018512
protein coding gene Chr11:102302099-102354614 (-)



Homology
more
  • Human Ortholog
    ACLY, ATP citrate lyase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACLY, ATP citrate lyase
  • Synonyms
    ACL, ATPCL, CLATP
  • Links
    NCBI Gene ID: 47
    neXtProt AC: NX_P53396
    UniProt: P53396

  • Chr Location
    17q21.2; chr17:41866917-41930545 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020917 Ensembl Gene Model | MGI Sequence Detail 51648 C57BL/6J ±  kb
transcript ENSMUST00000107389 Ensembl | MGI Sequence Detail 4426 Not Applicable  
polypeptide ENSMUSP00000103012 Ensembl | MGI Sequence Detail 1101 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 20
    Primer pair 6
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-24127, MGI:2144554, MGI:2443004
References
more
  • Summaries
    All 98
    Developmental Gene Expression 22
    Gene Ontology 8
    Phenotypes 34
  • Earliest
    J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
  • Latest
    J:343078 Diniz F, et al., Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance. Nat Commun. 2023 Nov 25;14(1):7733

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory