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Tfap4
Gene Detail
Symbol

Name
ID
Tfap4
transcription factor AP4
MGI:103239
Synonyms
AP-4, bHLHc41, D930048N17Rik, Tcfap4
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.45 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:4544661-4559720 bp, - strand
From Ensembl annotation of GRCm38

  15060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFAP4
Gene Tree: Tfap4

Human
homologs
TFAP4, transcription factor AP-4 (activating enhancer binding protein 4)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7023
neXtProt AC: NX_Q01664

Human Synonyms: AP-4, bHLHc41

Human Chr (Location): 16p13; chr16:4257186-4273000 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(114) : Gene trapped(110) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit partial prenatal lethality and reduced suppression of Cd4 in double negative thymocytes.
 
Interactions
Tfap4 interacts with 181 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (89)    Tissues (62)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
Northern blot 18
Western blot 17
RT-PCR 8
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tfap4    NEW 
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000005718 (Evidence)
Entrez Gene 83383 (Evidence)
UniGene 273210
DFCI TC1582864
DoTS DT.40171906
NIA Mouse Gene Index U036740
Consensus CDS Project CCDS27919.1
International Mouse Phenotyping Consortium Status Tfap4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005718 Ensembl Gene Model | MGI Sequence Detail 15060 C57BL/6J ±  kb
transcript ENSMUST00000005862 Ensembl | MGI Sequence Detail 2113 Not Applicable 
polypeptide ENSMUSP00000005862 Ensembl | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(14) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016266 transcription factor AP-4
References
(Earliest) J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
(Latest) J:176461 Egawa T, et al., Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14873-8
All references(50)
Other
accession IDs
MGD-MRK-24114, MGI:1932513, MGI:2146466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory