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Tfap4 Gene Detail
Summary
  • Symbol
    Tfap4
  • Name
    transcription factor AP4
  • Synonyms
    AP-4, bHLHc41, D930048N17Rik, Tcfap4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103239
    NCBI Gene: 83383
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4362525-4377718 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.45 cM, cytoband A1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    304 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103239
 protein coding gene Chr16:4362525-4378625 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022464
 protein coding gene Chr16:1030264-1044857 (-)
A/J MGP_AJ_G0022426
 protein coding gene Chr16:872082-886838 (-)
AKR/J MGP_AKRJ_G0022403
 protein coding gene Chr16:1037681-1054518 (-)
BALB/cJ MGP_BALBcJ_G0022431
 protein coding gene Chr16:1023190-1038259 (-)
C3H/HeJ MGP_C3HHeJ_G0022198
 protein coding gene Chr16:1068093-1084695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022880
 protein coding gene Chr16:1095290-1111617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020401
 protein coding gene Chr16:814352-828878 (-)
CAST/EiJ MGP_CASTEiJ_G0021724
 protein coding gene Chr16:1055637-1073058 (-)
CBA/J MGP_CBAJ_G0022167
 protein coding gene Chr16:1176553-1191305 (-)
DBA/2J MGP_DBA2J_G0022298
 protein coding gene Chr16:979065-994323 (-)
FVB/NJ MGP_FVBNJ_G0022273
 protein coding gene Chr16:961896-976967 (-)
LP/J MGP_LPJ_G0022366
 protein coding gene Chr16:1034211-1048961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022295
 protein coding gene Chr16:1044983-1063112 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022892
 protein coding gene Chr16:1016180-1032238 (-)
PWK/PhJ MGP_PWKPhJ_G0021464
 protein coding gene Chr16:1038553-1053668 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021295
 protein coding gene Chr16:1106361-1120566 (-)
WSB/EiJ MGP_WSBEiJ_G0021773
 protein coding gene Chr16:1033532-1049497 (-)



Homology
more
  • Human Ortholog
    TFAP4, transcription factor AP-4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFAP4, transcription factor AP-4
  • Synonyms
    AP-4, bHLHc41
  • Links
    NCBI Gene ID: 7023
    UniProt: Q01664

  • Chr Location
    16p13.3; chr16:4257186-4273075 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial prenatal lethality and reduced suppression of Cd4 in double negative thymocytes.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    72
  • cDNA Data
    26
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005718 Ensembl Gene Model | MGI Sequence Detail 15194 C57BL/6J ±  kb
    transcript ENSMUST00000005862 Ensembl | MGI Sequence Detail 2247 Not Applicable  
    polypeptide ENSMUSP00000005862 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR052207 Max-like/E-box-binding transcription factors
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    • GlyGen
      Q9JIZ5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24114, MGI:1932513, MGI:2146466
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 11
      Phenotypes 19
    • Earliest
      J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
    • Latest
      J:373572 Murphy MK, et al., The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8(+) T cells. Immunity. 2025 Oct 14;58(10):2472-2488.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/16/2026
    MGI 6.24     		The Jackson Laboratory