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Tfap4
Gene Detail
 Symbol
Name
ID
Tfap4
transcription factor AP4
MGI:103239
Synonyms AP-4, bHLHc41, D930048N17Rik, Tcfap4
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.45 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:4544661-4559720 bp, - strand
From NCBI annotation of GRCm38

  15060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tfap4

Human
homologs
Human Homolog TFAP4, transcription factor AP-4 (activating enhancer binding protein 4)
NCBI Gene ID 7023
neXtProt AC  NX_Q01664
Human Synonyms  AP-4, bHLHc41
Human Chr (Location)  16p13; chr16:4257186-4273000 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(114) : Gene trapped(110) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit partial prenatal lethality and reduced suppression of Cd4 in double negative thymocytes.
 
Interactions
Tfap4 interacts with 181 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cellular response to dexamethasone stimulus, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ...
Component nucleus, transcriptional repressor complex
Function DNA binding, E-box binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (89)    Tissues (62)    Images (9)
Theiler Stages: 2, 3, 4, 5, 16, 17, 19, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 46
Northern blot 18
Western blot 17
RT-PCR 8
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005718 (Evidence)
Entrez Gene83383 (Evidence)
UniGene273210
DFCITC1582864
DoTSDT.40171906
NIA Mouse Gene IndexU036740
Consensus CDS ProjectCCDS27919.1
International Mouse Knockout Project StatusTfap4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83383 NCBI Gene Model | MGI Sequence Detail 15060 C57BL/6J ±  kb
transcript NM_031182 RefSeq | MGI Sequence Detail 2113 C57BL/6 
polypeptide NP_112459 RefSeq | MGI Sequence Detail 338 C57BL/6 

For the selected sequences
All sequences(29) RefSeq(14) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016266 transcription factor AP-4
References (Earliest) J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
(Latest) J:176461 Egawa T, et al., Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14873-8
All references(52)
Other
accession IDs
MGD-MRK-24114, MGI:1932513, MGI:2146466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory