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Efna1
Gene Detail
Symbol

Name
ID
Efna1
ephrin A1
MGI:103236
Synonyms
B61, EFL-1, Epl1, Eplg1, Lerk1, LERK-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:89271733-89281142 bp, - strand
From VEGA annotation of GRCm38

  9410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EFNA1
Protein SuperFamily: Ephrin-A
Gene Tree: Efna1

Human
homologs
EFNA1, ephrin-A1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1942
neXtProt AC: NX_P20827

Human Synonyms: B61, ECKLG, EFL1, EPLG1, LERK1, LERK-1, TNFAIP4

Human Chr (Location): 1q21-q22; chr1:155127873-155134910 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased cardiac muscle contractility associated with increased mitral and aortic valve thickness and increased epithelial to mesenchyme transition in outflow tract endocardial cushions.
 
Interactions
Efna1 interacts with 164 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, angiogenesis, ...
Component anchored component of membrane, anchored component of plasma membrane, ...
Function ephrin receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (354)    Tissues (264)    Images (104)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 328
Western blot 5
RT-PCR 14
cDNA source data(61)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase efna1 ; ZFIN efna1a, efna1b    NEW 
Molecular
reagents
All nucleic(69) cDNA(63) Primer pair(4) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028819 (Evidence)
Ensembl Gene Model ENSMUSG00000027954 (Evidence)
Entrez Gene 13636 (Evidence)
UniGene 15675
DFCI TC1578761, TC1635107, TC1628262
DoTS DT.492499, DT.94265089, DT.94265082
NIA Mouse Gene Index U024274
Consensus CDS Project CCDS17501.1, CCDS50961.1
International Mouse Phenotyping Consortium Status Efna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028819 VEGA Gene Model | MGI Sequence Detail 9410 C57BL/6J ±  kb
transcript OTTMUST00000071370 VEGA | MGI Sequence Detail 1480 Not Applicable 
polypeptide OTTMUSP00000036557 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006916 ephrin-A1
References
(Earliest) J:32147 Holzman LB, et al., A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol Cell Biol. 1990 Nov;10(11):5830-8
(Latest) J:214811 Weiss AC, et al., Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014 Sep;141(17):3420-30
All references(82)
Other
accession IDs
MGD-MRK-24110, MGI:2139679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory