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Gene Detail
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
Synonyms D15F32S1h, D7H15F32S1, D7H15F37S1, jdf2, rjs
Feature Type protein coding gene
Genetic Map
Chromosome 7
33.42 cM
Detailed Genetic Map ± 1 cM

Mapping data(9)
Sequence Map
Chr7:56050155-56231794 bp, + strand
From Ensembl annotation of GRCm38

  181640 bp   ±  kb flank

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Mouse Genome Browser
HomoloGene:3430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Herc2

Human Homolog HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2
NCBI Gene ID 8924
neXtProt AC  NX_O95714
Human Synonyms  D15F37S1, jdf2, MRT38, p528, SHEP1
Human Chr (Location)  15q13; chr15:28111037-28322167 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human HERC2
alleles, and
All mutations/alleles(27) : Chemically induced (ENU)(10) Gene trapped(14) Spontaneous(1) Targeted(1) Transgenic(1)
Genomic Mutations involving Herc2 (2)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for null mutations exhibit runting, nervousness, and incoordination. Males are sterile with sperm abnormalities, while females show reduced fertility and impaired maternal ability. Also see alleles at the Oca2 (p) locus for deletions that encompass the Herc2 gene.
Alleles Annotated to Human Diseases(2)   
Herc2 interacts with 330 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (30 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, cytoskeleton, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (14)    Images (23)
Theiler Stages: 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 76
Northern blot 14
RNase protection 13
cDNA source data(133)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(134) Genomic(1) cDNA(133)
Microarray probesets(6)
Other database
Ensembl Gene ModelENSMUSG00000030451 (Evidence)
Entrez Gene15204 (Evidence)
DoTSDT.101399508, DT.529419, DT.87056283, DT.91387505, DT.94247726, DT.97414850
NIA Mouse Gene IndexU008155, U056945
Consensus CDS ProjectCCDS21318.1
International Mouse Knockout Project StatusHerc2
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030451 Ensembl Gene Model | MGI Sequence Detail 181640 C57BL/6J ±  kb
transcript ENSMUST00000076226 Ensembl | MGI Sequence Detail 15342 Not Applicable 
polypeptide ENSMUSP00000075579 Ensembl | MGI Sequence Detail 4836 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(1676 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1680)
InterPro IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
InterPro IPR006624 Beta-propeller repeat TECPR
InterPro IPR021097 CPH domain
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000569 HECT
InterPro IPR010606 Mib-herc2
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR014722 Ribosomal protein L2 domain 2
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000029541 E3 ubiquitin-protein ligase HERC2
References (Earliest) J:13043 Gruneberg H, Genetical studies on the skeleton of the mouse. XII. The development of undulated. J Genet. 1954;52(2):441-455
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(51)
accession IDs
MGD-MRK-24107, MGD-MRK-4005, MGD-MRK-7791, MGD-MRK-7792, MGI:1270154, MGI:93883

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory