About   Help   FAQ
Cyp4b1 Gene Detail
Summary
  • Symbol
    Cyp4b1
  • Name
    cytochrome P450, family 4, subfamily b, polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103225
    NCBI Gene: 13120
  • Gene Overview
    MyGene.info: CYP4B1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115624728-115647705 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103225
protein coding gene Chr4:115624725-115647723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028605
protein coding gene Chr4:116459121-116483029 (-)
A/J MGP_AJ_G0028566
protein coding gene Chr4:112027651-112049213 (-)
AKR/J MGP_AKRJ_G0028515
protein coding gene Chr4:114423990-114460760 (-)
BALB/cJ MGP_BALBcJ_G0028587
protein coding gene Chr4:112639983-112663549 (-)
C3H/HeJ MGP_C3HHeJ_G0028301
protein coding gene Chr4:115970911-116005189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029028
protein coding gene Chr4:120976160-120998279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026312
protein coding gene Chr4:106115707-106138297 (-)
CAST/EiJ MGP_CASTEiJ_G0027736
protein coding gene Chr4:113234378-113253164 (-)
CBA/J MGP_CBAJ_G0028268
protein coding gene Chr4:124233650-124274038 (-)
DBA/2J MGP_DBA2J_G0028416
protein coding gene Chr4:112674683-112698505 (-)
FVB/NJ MGP_FVBNJ_G0028384
protein coding gene Chr4:111173090-111201002 (-)
LP/J MGP_LPJ_G0028516
protein coding gene Chr4:116600089-116732175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028411
protein coding gene Chr4:129305573-129331467 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029065
protein coding gene Chr4:115592762-115621390 (-)
PWK/PhJ MGP_PWKPhJ_G0027461
protein coding gene Chr4:109439840-109468073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027284
protein coding gene Chr4:111823425-111857822 (-)
WSB/EiJ MGP_WSBEiJ_G0027814
protein coding gene Chr4:115431250-115456526 (-)



Homology
more
  • Human Ortholog
    CYP4B1, cytochrome P450 family 4 subfamily B member 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    CYP4B1, cytochrome P450 family 4 subfamily B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYPIVB1, P-450HP
  • Links
    NCBI Gene ID: 1580
    neXtProt AC: NX_P13584
    UniProt: P13584

  • Chr Location
    1p33; chr1:46798995-46819349 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to 4-ipomeanol activation and toxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13120 NCBI Gene Model | MGI Sequence Detail 22978 C57BL/6J ±  kb
    transcript NM_007823 RefSeq | MGI Sequence Detail 1917 C57BL/6  
    polypeptide Q64462 UniProt | EBI | MGI Sequence Detail 511 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 274
      Genomic 1
      cDNA 272
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24096
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:27761 Imaoka S, et al., Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1. Arch Biochem Biophys. 1995 Aug 1;321(1):255-62
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory