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Gene Detail
zinc finger and BTB domain containing 16
Synonyms Green's luxoid, PLZF, Zfp145
Feature Type protein coding gene
Genetic Map
Chromosome 9
26.47 cM
Detailed Genetic Map ± 1 cM

Mapping data(22)
Sequence Map
Chr9:48654311-48835945 bp, - strand
From Ensembl annotation of GRCm38

  181635 bp   ±  kb flank

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Mouse Genome Browser
HomoloGene:21214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zbtb16

Human Homolog ZBTB16, zinc finger and BTB domain containing 16
NCBI Gene ID 7704
neXtProt AC  NX_Q05516
Human Synonyms  PLZF, ZNF145
Human Chr (Location)  11q23.1; chr11:114059567-114250676 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZBTB16
alleles, and
All mutations/alleles(9) : Chemically induced (ENU)(2) Chemically induced (other)(1) Spontaneous(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Zbtb16 interacts with 273 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (49 annotations)
Process anterior/posterior pattern specification, cartilage development, ...
Component cytosol, nuclear body, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Literature Summary: (42 records)
Data Summary: Results (228)    Tissues (163)    Images (63)
Theiler Stages: 11, 13, 15, 17, 18, 21, 22, 23, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 218
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(20) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
Ensembl Gene ModelENSMUSG00000066687 (Evidence)
Entrez Gene235320 (Evidence)
DFCITC1601528, TC1653003, TC1689165
DoTSDT.101309779, DT.101360589, DT.40136349, DT.40175915
NIA Mouse Gene IndexU081113
Consensus CDS ProjectCCDS23158.1
International Mouse Knockout Project StatusZbtb16
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181635 C57BL/6J ±  kb
transcript ENSMUST00000093852 Ensembl | MGI Sequence Detail 5100 Not Applicable 
polypeptide ENSMUSP00000091374 Ensembl | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(2007 from dbSNP Build 137)
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017565 zinc finger and BTB domain-containing protein 16
References (Earliest) J:13069 Green MC, Luxoid, a new hereditary leg and foot abnormality in the house mouse. J Hered. 1955;46:91-99
(Latest) J:209131 Saba R, et al., CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014 May 15;389(2):173-81
All references(112)
accession IDs
MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory