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Zbtb16 Gene Detail
Summary
  • Symbol
    Zbtb16
  • Name
    zinc finger and BTB domain containing 16
  • Synonyms
    Green's luxoid, PLZF, Zfp145
  • Feature Type
    protein coding gene
  • IDs
    MGI:103222
    NCBI Gene: 235320
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:48654297-48836222 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      181926 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.47 cM
  • Mapping Data
    22 experiments
Homology
more
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PLZF, ZNF145
  • Links
    NCBI Gene ID: 7704
    neXtProt AC: NX_Q05516
    UniProt: Q05516

  • Chr Location
    11q23.2; chr11:114059576-114256765 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21214
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZBTB16
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    5 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 9 alleles in 12 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181926 C57BL/6J ±  kb
    transcript ENSMUST00000093852 Ensembl | MGI Sequence Detail 5114 Not Applicable  
    polypeptide ENSMUSP00000091374 Ensembl | MGI Sequence Detail 673 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1979 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 70
      Diseases 2
      Gene Ontology 13
      Phenotypes 58
    • Earliest
      J:13069 Green MC, Luxoid, a new hereditary leg and foot abnormality in the house mouse. J Hered. 1955;46:91-99
    • Latest
      J:264161 Kasler HG, et al., Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells. Elife. 2018 Apr 17;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory