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Zbtb16 Gene Detail
Summary
  • Symbol
    Zbtb16
  • Name
    zinc finger and BTB domain containing 16
  • Synonyms
    Green's luxoid, PLZF, Zfp145
  • Feature Type
    protein coding gene
  • IDs
    MGI:103222
    NCBI Gene: 235320
Location & Maps
more
  • Sequence Map
    Chr9:48654311-48835945 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      181635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.47 cM
  • Mapping Data
    22 experiments
Homology
more
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PLZF, ZNF145
  • Links
    NCBI Gene ID: 7704
    neXtProt AC: NX_Q05516

  • Chr Location
    11q23.1; chr11:114059579-114250676 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ZBTB16 associations

Human Disease Mouse Models
       Skeletal Defects, Genital Hypoplasia, and Mental Retardation   OMIM: 612447
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 9 alleles in 12 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Spontaneous
    2
  • Targeted
    4
  • Transgenic
    5
  • Incidental Mutations
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181635 C57BL/6J ±  kb
transcript ENSMUST00000093852 Ensembl | MGI Sequence Detail 5100 Not Applicable  
polypeptide ENSMUSP00000091374 Ensembl | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1979 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851
References
more
  • Summaries
    All 127
    Developmental Gene Expression 55
    Diseases 2
    Gene Ontology 13
    Phenotypes 49
  • Earliest
    J:13069 Green MC, Luxoid, a new hereditary leg and foot abnormality in the house mouse. J Hered. 1955;46:91-99
  • Latest
    J:234504 Shum EY, et al., The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016 Apr 7;165(2):382-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory