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Zbtb16
Gene Detail
Symbol

Name
ID
Zbtb16
zinc finger and BTB domain containing 16
MGI:103222
Synonyms
Green's luxoid, PLZF, Zfp145
Feature Type
protein coding gene
Genetic Map
Chromosome 9
26.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr9:48654311-48835945 bp, - strand
From Ensembl annotation of GRCm38

  181635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZBTB16
Gene Tree: Zbtb16

Human
homologs
ZBTB16, zinc finger and BTB domain containing 16
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7704
neXtProt AC: NX_Q05516

Human Synonyms: PLZF, ZNF145

Human Chr (Location): 11q23.1; chr11:114059579-114250676 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZBTB16

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(2) Chemically induced (other)(1) Spontaneous(2) Targeted(4) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
 
Mutations Annotated to Human Diseases (5)    Phenotype Images(1)
Interactions
Zbtb16 interacts with 273 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process anterior/posterior pattern specification, cartilage development, ...
Component cytosol, nuclear body, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (231)    Tissues (163)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 218
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase zbtb16 ; ZFIN zbtb16a, zbtb16b    NEW 
Molecular
reagents
All nucleic(20) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000066687 (Evidence)
Entrez Gene 235320 (Evidence)
DFCI TC1601528, TC1653003, TC1689165
DoTS DT.101309779, DT.101360589, DT.40136349, DT.40175915
NIA Mouse Gene Index U081113
Consensus CDS Project CCDS23158.1
International Mouse Phenotyping Consortium Status Zbtb16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181635 C57BL/6J ±  kb
transcript ENSMUST00000093852 Ensembl | MGI Sequence Detail 5100 Not Applicable 
polypeptide ENSMUSP00000091374 Ensembl | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(2007 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000210 BTB/POZ domain
InterPro IPR011333 POZ domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017565 zinc finger and BTB domain-containing protein 16
References
(Earliest) J:13069 Green MC, Luxoid, a new hereditary leg and foot abnormality in the house mouse. J Hered. 1955;46:91-99
(Latest) J:222608 Lynch L, et al., Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan;16(1):85-95
All references(121)
Other
accession IDs
MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory