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Meox1 Gene Detail
Summary
  • Symbol
    Meox1
  • Name
    mesenchyme homeobox 1
  • Synonyms
    D330041M02Rik, Mox1, Mox-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103220
    NCBI Gene: 17285
  • Gene Overview
    MyGene.info: MEOX1
Location & Maps
more
  • Sequence Map
    Chr11:101877510-101894374 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16865 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KFS2, MOX1
  • Links
    NCBI Gene ID: 4222
    neXtProt AC: NX_P50221

  • Chr Location
    17q21.31; chr17:43640389-43661954 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MEOX1 associations

Human Disease Mouse Models
       Klippel-Feil Syndrome 2, Autosomal Recessive; KFS2   OMIM: 214300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    16
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    1 involving Meox1
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit hemi-vertebrae, and rib, vertebral, and cranial-vertebral fusions, but are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002088 VEGA Gene Model | MGI Sequence Detail 16865 C57BL/6J ±  kb
transcript OTTMUST00000004226 VEGA | MGI Sequence Detail 2228 Not Applicable  
polypeptide OTTMUSP00000002010 VEGA | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 41
    Genomic 1
    cDNA 26
    Primer pair 5
    Other 9

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12394, MGD-MRK-12396, MGD-MRK-24090, MGI:2144139
References
more
  • Summaries
    All 174
    Developmental Gene Expression 137
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
  • Latest
    J:235727 Kuta A, et al., Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 2016 Jul 1;143(13):2367-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory