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Meox1 Gene Detail
Summary
  • Symbol
    Meox1
  • Name
    mesenchyme homeobox 1
  • Synonyms
    D330041M02Rik, Mox1, Mox-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103220
    NCBI Gene: 17285
  • Gene Overview
    MyGene.info: MEOX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101877510-101894354 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103220
protein coding gene Chr11:101877510-101894374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019213
protein coding gene Chr11:104807383-104827204 (-)
A/J MGP_AJ_G0019181
protein coding gene Chr11:100387941-100404807 (-)
AKR/J MGP_AKRJ_G0019150
protein coding gene Chr11:103499549-103516401 (-)
BALB/cJ MGP_BALBcJ_G0019155
protein coding gene Chr11:100870111-100887404 (-)
C3H/HeJ MGP_C3HHeJ_G0018964
protein coding gene Chr11:103702759-103720830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019604
protein coding gene Chr11:108084646-108102347 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017230
protein coding gene Chr11:97808380-97826582 (-)
CAST/EiJ MGP_CASTEiJ_G0018518
protein coding gene Chr11:104655342-104675075 (-)
CBA/J MGP_CBAJ_G0018933
protein coding gene Chr11:112532737-112551417 (-)
DBA/2J MGP_DBA2J_G0019045
protein coding gene Chr11:99910179-99928492 (-)
FVB/NJ MGP_FVBNJ_G0019035
protein coding gene Chr11:99439466-99456555 (-)
LP/J MGP_LPJ_G0019114
protein coding gene Chr11:105328742-105346818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019066
protein coding gene Chr11:112077140-112095173 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019642
protein coding gene Chr11:103850050-103869446 (-)
PWK/PhJ MGP_PWKPhJ_G0018281
protein coding gene Chr11:100964217-100983287 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018073
protein coding gene Chr11:103590340-103609806 (-)
WSB/EiJ MGP_WSBEiJ_G0018567
protein coding gene Chr11:103835560-103855058 (-)



Homology
more
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KFS2, MOX1
  • Links
    NCBI Gene ID: 4222
    neXtProt AC: NX_P50221
    UniProt: P50221

  • Chr Location
    17q21.31; chr17:43640389-43661954 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MEOX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hemi-vertebrae, and rib, vertebral, and cranial-vertebral fusions, but are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17285 NCBI Gene Model | MGI Sequence Detail 16845 C57BL/6J ±  kb
    transcript NM_010791 RefSeq | MGI Sequence Detail 2235 C57BL/6  
    polypeptide P32442 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 28
      Primer pair 7
      Other 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12394, MGD-MRK-12396, MGD-MRK-24090, MGI:2144139
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 146
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
    • Latest
      J:259848 Chal J, et al., Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory