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Adsl Gene Detail
Summary
  • Symbol
    Adsl
  • Name
    adenylosuccinate lyase
  • Feature Type
    protein coding gene
  • IDs
    MGI:103202
    NCBI Gene: 11564
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:80832691-80855147 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    27
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103202
 protein coding gene Chr15:80832691-80855148 (+)
129S1/SvImJ ENSMUSG00200050874
 protein coding gene Chr15:77935348-77938859 (+)
129S1/SvImJ ENSMUSGG00200054960
 protein coding gene Chr15:77946966-77950529 (+)
A/J ENSMUSG00195051185
 protein coding gene Chr15:77882138-77885657 (+)
A/J ENSMUSGG00195055523
 protein coding gene Chr15:77893765-77897328 (+)
AKR/J ENSMUSG00220046207
 protein coding gene Chr15:77925240-77928757 (+)
AKR/J ENSMUSGG00220054311
 protein coding gene Chr15:77936865-77940428 (+)
BALB/cJ ENSMUSG00180050645
 protein coding gene Chr15:77759157-77762672 (+)
BALB/cJ ENSMUSGG00180054980
 protein coding gene Chr15:77770780-77774343 (+)
C3H/HeJ ENSMUSG00175040813
 protein coding gene Chr15:78070196-78073712 (+)
C3H/HeJ ENSMUSGG00175055147
 protein coding gene Chr15:78081820-78085385 (+)
C57BL/6NJ ENSMUSG00215052454
 protein coding gene Chr15:77843903-77847414 (+)
C57BL/6NJ ENSMUSGG00215055819
 protein coding gene Chr15:77855521-77859086 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020044
 protein coding gene Chr15:74971395-74994169 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055072
 protein coding gene Chr15:77856921-77860486 (+)
CBA/J ENSMUSG00210037719
 protein coding gene Chr15:77845296-77848813 (+)
DBA/2J ENSMUSGG00185057949
 protein coding gene Chr15:77879559-77883121 (+)
DBA/2J ENSMUSG00185043471
 protein coding gene Chr15:77867934-77871455 (+)
FVB/NJ ENSMUSGG00205054654
 protein coding gene Chr15:77594261-77597824 (+)
FVB/NJ ENSMUSG00205046763
 protein coding gene Chr15:77582637-77586154 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055888
 protein coding gene Chr15:81196176-81199739 (+)
LP/J ENSMUSG00230052221
 protein coding gene Chr15:81184558-81188069 (+)
NOD/ShiLtJ ENSMUSGG00190055114
 protein coding gene Chr15:77874046-77877609 (+)
NOD/ShiLtJ ENSMUSG00190049080
 protein coding gene Chr15:77862421-77865938 (+)
NZO/HlLtJ ENSMUSGG00225055282
 protein coding gene Chr15:81538058-81541598 (+)
NZO/HlLtJ ENSMUSG00225047790
 protein coding gene Chr15:81521191-81524714 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010048661
 protein coding gene Chr15:79312670-79332217 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ADSL, adenylosuccinate lyase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADSL, adenylosuccinate lyase
  • Synonyms
    AMPS, ASASE, ASL
  • Links
    NCBI Gene ID: 158
    UniProt: P30566

  • Chr Location
    22q13.1; chr22:40346461-40390463 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADSL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous codon changes (ArgAla>GlnVal) in the active domain that mimic the human ortholog result in reduced stability and activity of the encoded enzyme.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    144
  • cDNA Data
    89
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022407 Ensembl Gene Model | MGI Sequence Detail 22457 C57BL/6J ±  kb
    transcript ENSMUST00000023043 Ensembl | MGI Sequence Detail 3711 Not Applicable  
    polypeptide ENSMUSP00000023043 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 90
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24070
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:306717 Atkinson MR, et al., Inhibition of adenylosuccinate synthetase and adenylosuccinate lyase from Ehrlich ascites-tumour cells by 6-thioinosine 5'-phosphate. Biochem J. 1964 Aug;92(2):398-404
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory