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Adsl
Gene Detail
 Symbol
Name
ID
Adsl
adenylosuccinate lyase
MGI:103202
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:80948490-80970947 bp, + strand
From VEGA annotation of GRCm38

  22458 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fumarate hydratase
Gene Tree: Adsl

Human
homologs
Human Homolog ADSL, adenylosuccinate lyase
NCBI Gene ID 158
neXtProt AC  NX_P30566
Human Synonyms  AMPS, ASASE, ASL
Human Chr (Location)  22q13.2; chr22:40346500-40366573 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADSL
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Radiation induced(1) Targeted(2)
Genomic Mutations involving Adsl (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Adsl interacts with 240 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process aerobic respiration, AMP biosynthetic process, ...
Component cytosol, mitochondrion
Function catalytic activity, lyase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (227)    Tissues (120)    Images (28)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 227
cDNA source data(87)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) cDNA(88) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035645 (Evidence)
Ensembl Gene ModelENSMUSG00000022407 (Evidence)
Entrez Gene11564 (Evidence)
UniGene38151
DFCITC1574066, TC1720105
DoTSDT.101378792, DT.525958, DT.87066004, DT.94141343
NIA Mouse Gene IndexU016459
EC4.3.2.2
Consensus CDS ProjectCCDS27664.1
International Mouse Knockout Project StatusAdsl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035645 VEGA Gene Model | MGI Sequence Detail 22458 C57BL/6J ±  kb
transcript OTTMUST00000091232 VEGA | MGI Sequence Detail 3712 Not Applicable 
polypeptide OTTMUSP00000050230 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004769 Adenylosuccinate lyase
InterPro IPR019468 Adenylosuccinate lyase C-terminal
InterPro IPR024083 Fumarase/histidase, N-terminal
InterPro IPR000362 Fumarate lyase
InterPro IPR020557 Fumarate lyase, conserved site
InterPro IPR022761 Fumarate lyase, N-terminal
InterPro IPR008948 L-Aspartase-like
Protein Ontology PR:000003794 adenylosuccinate lyase
References (Earliest) J:48779 Stone RL, et al., A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. Nat Genet. 1992 Apr;1(1):59-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGD-MRK-24070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory