Adsl
Gene Detail

Symbol Name ID

Adsl adenylosuccinate lyase MGI:103202

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:80948490-80970947 bp, + strand From VEGA annotation of GRCm38   22458 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fumarate hydratase
Gene Tree: Adsl

Human homologs

Human Homolog		ADSL, adenylosuccinate lyase
NCBI Gene ID		158
neXtProt AC		NX_P30566
Human Synonyms		AMPS, ASASE, ASL
Human Chr (Location)		22q13.2; chr22:40742504-40762577 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADSL

Alleles and phenotypes

All alleles(18) : Targeted(1) Gene trapped(17)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	aerobic respiration, AMP biosynthetic process, ...
Component	cytoplasm, cytosol, ...
Function	catalytic activity, lyase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (227)    Tissues (120)    Images (28)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	227

cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(90) cDNA(87) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035645 (Evidence)
Ensembl Gene Model	ENSMUSG00000022407 (Evidence)
Entrez Gene	11564 (Evidence)
UniGene	38151
DFCI	TC1574066, TC1720105
DoTS	DT.101378792, DT.525958, DT.87066004, DT.94141343
NIA Mouse Gene Index	U016459
EC	4.3.2.2
Consensus CDS Project	CCDS27664.1
International Mouse Knockout Project Status	Adsl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035645	VEGA Gene Model | MGI Sequence Detail	22458	C57BL/6J
transcript	OTTMUST00000091232	VEGA | MGI Sequence Detail	3712	Not Applicable
polypeptide	OTTMUSP00000050230	VEGA | MGI Sequence Detail	484	Not Applicable

All sequences(67) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004769	Adenylosuccinate lyase
InterPro	IPR019468	Adenylosuccinate lyase C-terminal
InterPro	IPR003031	Delta crystallin
InterPro	IPR024083	Fumarase/histidase, N-terminal
InterPro	IPR000362	Fumarate lyase
InterPro	IPR020557	Fumarate lyase, conserved site
InterPro	IPR022761	Fumarate lyase, N-terminal
InterPro	IPR008948	L-Aspartase-like
Protein Ontology	PR:000003794	adenylosuccinate lyase

References

(Earliest) J:48779 Stone RL, et al., A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. Nat Genet. 1992 Apr;1(1):59-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Other accession IDs

MGD-MRK-24070