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Aqp1
Gene Detail
Symbol

Name
ID
Aqp1
aquaporin 1
MGI:103201
Synonyms
CHIP28
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:55336432-55348555 bp, + strand
From VEGA annotation of GRCm38

  12124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: AQP1
Protein SuperFamily: aquaporin
Gene Tree: Aqp1

Human
homologs
AQP1, aquaporin 1 (Colton blood group)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 358
neXtProt AC: NX_P29972

Human Synonyms: AQP-CHIP, CHIP28, CO

Human Chr (Location): 7p14; chr7:30911800-30925516 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in urine hypoosmality.
 
Interactions
Aqp1 interacts with 236 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (53 records)
Data Summary: Results (660)    Tissues (174)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 153
RNA in situ 453
Western blot 21
RT-PCR 33
cDNA source data(169)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AQP1 ; Xenbase aqp1 ; ZFIN aqp1a.1, aqp1a.2    NEW 
Molecular
reagents
All nucleic(183) Genomic(8) cDNA(169) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026098 (Evidence)
Ensembl Gene Model ENSMUSG00000004655 (Evidence)
Entrez Gene 11826 (Evidence)
UniGene 18625
DFCI TC1573430, TC1670101, TC1595971
DoTS DT.94408293, DT.101377050
NIA Mouse Gene Index U006904
Consensus CDS Project CCDS20164.1
International Mouse Phenotyping Consortium Status Aqp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026098 VEGA Gene Model | MGI Sequence Detail 12124 C57BL/6J ±  kb
transcript OTTMUST00000064430 VEGA | MGI Sequence Detail 2627 Not Applicable 
polypeptide OTTMUSP00000031991 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023274 Aquaporin 1
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004177 aquaporin-1
References
(Earliest) J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29
(Latest) J:220085 Kumari SS, et al., Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration. Biochem Biophys Res Commun. 2014 Oct 3;452(4):986-91
All references(165)
Other
accession IDs
MGD-MRK-24069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory