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Aqp1
Gene Detail
 Symbol
Name
ID
Aqp1
aquaporin 1
MGI:103201
Synonyms CHIP28
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:55336432-55348555 bp, + strand
From VEGA annotation of GRCm38

  12124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Aqp1

Human
homologs
Human Homolog AQP1, aquaporin 1 (Colton blood group)
NCBI Gene ID 358
neXtProt AC  NX_P29972
Human Synonyms  AQP-CHIP, CHIP28, CO
Human Chr (Location)  7p14; chr7:30911800-30925516 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in urine hypoosmality.
 
Interactions
Aqp1 interacts with 236 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (113 annotations)
Process ammonium transmembrane transport, ammonium transport, ...
Component apical part of cell, apical plasma membrane, ...
Function ammonium transmembrane transporter activity, carbon dioxide transmembrane transporter activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (670)    Tissues (176)    Images (66)
Theiler Stages: 2, 3, 4, 5, 14, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 153
RNA in situ 453
Western blot 21
RT-PCR 43
cDNA source data(169)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(182) Genomic(8) cDNA(169) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026098 (Evidence)
Ensembl Gene ModelENSMUSG00000004655 (Evidence)
Entrez Gene11826 (Evidence)
UniGene18625
DFCITC1573430, TC1595971, TC1670101
DoTSDT.101377050, DT.94408293
NIA Mouse Gene IndexU006904
Consensus CDS ProjectCCDS20164.1
International Mouse Knockout Project StatusAqp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026098 VEGA Gene Model | MGI Sequence Detail 12124 C57BL/6J ±  kb
transcript OTTMUST00000064430 VEGA | MGI Sequence Detail 2627 Not Applicable 
polypeptide OTTMUSP00000031991 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023274 Aquaporin 1
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004177 aquaporin-1
References (Earliest) J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29
(Latest) J:202950 Schnermann J, et al., Fluid reabsorption in proximal convoluted tubules of mice with gene deletions of claudin-2 and/or aquaporin1. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1352-64
All references(157)
Other
accession IDs
MGD-MRK-24069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory