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Mcm4 Gene Detail
Summary
  • Symbol
    Mcm4
  • Name
    minichromosome maintenance complex component 4
  • Synonyms
    19G, Cdc21, mCdc21, Mcmd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103199
    NCBI Gene: 17217
  • Gene Overview
    MyGene.info: MCM4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:15623897-15637400 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13504 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.09 cM, cytoband B1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC21, CDC54, hCdc21, IMD54, NKCD, NKGCD, P1-CDC21
  • Links
    NCBI Gene ID: 4173
    neXtProt AC: NX_P33991
    UniProt: P33991

  • Chr Location
    8q11.21; chr8:47960203-47978160 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this allele cause chromosomal instability as assessed by micronucleus levels in erythrocytes. Mice homozygous for a spontaneous allele exhibit early onset T cell acute lymphoblastic leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17217 NCBI Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
    transcript NM_008565 RefSeq | MGI Sequence Detail 3589 C57BL/6  
    polypeptide P49717 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      90 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24067, MGI:2146413, MGI:2146584
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:1385 Salles FJ, et al., Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev. 1992 Jul;6(7):1202-12
    • Latest
      J:241732 O'Driscoll M, The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. J Pathol. 2017 Jan;241(2):192-207

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory