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Mcm4 Gene Detail
Summary
  • Symbol
    Mcm4
  • Name
    minichromosome maintenance complex component 4
  • Synonyms
    19G, Cdc21, mCdc21, Mcmd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103199
    NCBI Gene: 17217
  • Gene Overview
    MyGene.info: MCM4
Location & Maps
more
  • Sequence Map
    Chr16:15623897-15637400 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13504 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC21, CDC54, hCdc21, NKCD, NKGCD, P1-CDC21
  • Links
    NCBI Gene ID: 4173
    neXtProt AC: NX_P33991

  • Chr Location
    8q11.2; chr8:47960203-47978160 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MCM4 associations

Human Disease Mouse Models
       Natural Killer Cell and Glucocorticoid Deficiency with DNA Repair Defect; NKGCD   OMIM: 609981
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 4 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Chemically induced (ENU)
    1
  • Gene trapped
    28
  • Spontaneous
    1
  • Targeted
    3
  • Incidental Mutations
Disruption of this allele cause chromosomal instability as assessed by micronucleus levels in erythrocytes. Mice homozygous for a spontaneous allele exhibit early onset T cell acute lymphoblastic leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17217 NCBI Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
transcript NM_008565 RefSeq | MGI Sequence Detail 3589 C57BL/6  
polypeptide P49717 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-24067, MGI:2146413, MGI:2146584
References
more
  • Summaries
    All 58
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:1385 Salles FJ, et al., Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev. 1992 Jul;6(7):1202-12
  • Latest
    J:197548 Pihlajoki M, et al., Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory