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Mcm4 Gene Detail
Summary
  • Symbol
    Mcm4
  • Name
    minichromosome maintenance complex component 4
  • Synonyms
    19G, Cdc21, mCdc21, Mcmd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103199
    NCBI Gene: 17217
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:15441761-15455264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.09 cM, cytoband B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103199
 protein coding gene Chr16:15441761-15455264 (-)
129S1/SvImJ ENSMUSG00200043027
 protein coding gene Chr16:12434274-12447778 (-)
A/J ENSMUSG00195029624
 protein coding gene Chr16:11992745-12006252 (-)
AKR/J ENSMUSG00220045370
 protein coding gene Chr16:12303949-12317456 (-)
BALB/cJ ENSMUSG00180030542
 protein coding gene Chr16:12232728-12246233 (-)
C3H/HeJ ENSMUSG00175037386
 protein coding gene Chr16:12379014-12392519 (-)
C57BL/6NJ ENSMUSG00215038553
 protein coding gene Chr16:12100559-12114063 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020486
 protein coding gene Chr16:12157508-12172788 (-)
CAST/EiJ ENSTCUG00005039562
 protein coding gene Chr16:12277689-12291163 (-)
CBA/J ENSMUSG00210044610
 protein coding gene Chr16:12395938-12409443 (-)
DBA/2J ENSMUSG00185027509
 protein coding gene Chr16:12341442-12354947 (-)
FVB/NJ ENSMUSG00205044176
 protein coding gene Chr16:12347780-12361287 (-)
JF1/MsJ ENSUMUG00000046060
 protein coding gene Chr16:12421560-12434823 (-)
LP/J ENSMUSG00230037780
 protein coding gene Chr16:14919964-14933469 (-)
NOD/ShiLtJ ENSMUSG00190025891
 protein coding gene Chr16:12481390-12494896 (-)
NZO/HlLtJ ENSMUSG00225030208
 protein coding gene Chr16:18165218-18178723 (-)
PWK/PhJ ENSLUMG00010047397
 protein coding gene Chr16:12312592-12325884 (-)
SPRET/EiJ ENSMSPG00010038588
 protein coding gene Chr16:12300284-12314582 (-)
WSB/EiJ ENSIUOG00005032389
 protein coding gene Chr16:12441412-12454902 (-)



Homology
more
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM4, minichromosome maintenance complex component 4
  • Synonyms
    CDC21, CDC54, hCdc21, IMD54, NKCD, NKGCD, P1-CDC21
  • Links
    NCBI Gene ID: 4173
    UniProt: P33991

  • Chr Location
    8q11.21; chr8:47960185-47978165 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MCM4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this allele cause chromosomal instability as assessed by micronucleus levels in erythrocytes. Mice homozygous for a spontaneous allele exhibit early onset T cell acute lymphoblastic leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    24
  • cDNA Data
    19
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17217 NCBI Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
    transcript NM_008565 RefSeq | MGI Sequence Detail 3589 ZRU/MplStud  
    polypeptide P49717 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 20
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24067, MGI:2146413, MGI:2146584
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 13
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:1385 Salles FJ, et al., Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev. 1992 Jul;6(7):1202-12
    • Latest
      J:383439 Munisha M, et al., Chronic replication stress-mediated genomic instability disrupts placenta development in mice. PLoS Genet. 2026 Apr;22(4):e1012111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory