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Mcm4
Gene Detail
Symbol

Name
ID
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
MGI:103199
Synonyms
19G, Cdc21, mCdc21, Mcmd4
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.09 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:15623897-15637400 bp, - strand
From NCBI annotation of GRCm38

  13504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCM4
Protein SuperFamily: replication licensing factor MCM4
Gene Tree: Mcm4

Human
homologs
MCM4, minichromosome maintenance complex component 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4173
neXtProt AC: NX_P33991

Human Synonyms: CDC21, CDC54, hCdc21, NKCD, NKGCD, P1-CDC21

Human Chr (Location): 8q11.2; chr8:47960203-47978160 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MCM4

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Chemically induced (ENU)(1) Gene trapped(28) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption of this allele cause chromosomal instability as assessed by micronucleus levels in erythrocytes. Mice homozygous for a spontaneous allele exhibit early onset T cell acute lymphoblastic leukemia.
 
Interactions
Mcm4 interacts with 143 markers (Mir1b, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell cycle, DNA replication, ...
Component MCM complex, membrane, ...
Function ATP binding, ATP-dependent DNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (19)    Tissues (19)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mcm4 ; ZFIN mcm4    NEW 
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022673 (Evidence)
Entrez Gene 17217 (Evidence)
DFCI TC1573385, TC1743848
DoTS DT.492985, DT.91589833, DT.94361902, DT.94361956
NIA Mouse Gene Index U036823
EC 3.6.4.12
Consensus CDS Project CCDS27977.1
International Mouse Phenotyping Consortium Status Mcm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17217 NCBI Gene Model | MGI Sequence Detail 13504 C57BL/6J ±  kb
transcript NM_008565 RefSeq | MGI Sequence Detail 3589 C57BL/6 
polypeptide P49717 UniProt | EBI | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR008047 Mini-chromosome maintenance complex protein 4
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR004039 Rubredoxin-type fold
Protein Ontology PR:000010246 DNA replication licensing factor MCM4
Graphical View of Protein Domain Structure
References
(Earliest) J:1385 Salles FJ, et al., Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev. 1992 Jul;6(7):1202-12
(Latest) J:197548 Pihlajoki M, et al., Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67
All references(60)
Other
accession IDs
MGD-MRK-24067, MGI:2146413, MGI:2146584

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory