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Mmp7
Gene Detail
Symbol

Name
ID
Mmp7
matrix metallopeptidase 7
MGI:103189
Synonyms
MAT, matrilysin
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:7692090-7699585 bp, + strand
From VEGA annotation of GRCm38

  7496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: MMP7
Protein SuperFamily: matrilysin-like proteinase
Gene Tree: Mmp7

Human
homologs
MMP7, matrix metallopeptidase 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4316
neXtProt AC: NX_P09237

Human Synonyms: MMP-7, MPSL1, PUMP-1

Human Chr (Location): 11q22.2; chr11:102520508-102530747 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to induced colitis and corneal wound neovascularization, decreased sensitivity to myocardial infarction and pancreatic duct ligation, impaired tracheal wound healing, and altered tumor susceptibility.
 
Interactions
Mmp7 interacts with 46 markers (Mir1b, Mir15b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process antibacterial peptide biosynthetic process, antibacterial peptide secretion, ...
Component cell surface, extracellular exosome, ...
Function heparin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (66)    Tissues (57)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 66
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MMP7 ; Xenbase mmp7    NEW 
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(16) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033289 (Evidence)
Ensembl Gene Model ENSMUSG00000018623 (Evidence)
Entrez Gene 17393 (Evidence)
UniGene 4825
DFCI TC1585074
DoTS DT.487628
EC 3.4.24.23
Consensus CDS Project CCDS40531.1
International Mouse Phenotyping Consortium Status Mmp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033289 VEGA Gene Model | MGI Sequence Detail 7496 C57BL/6J ±  kb
transcript OTTMUST00000083491 VEGA | MGI Sequence Detail 1068 Not Applicable 
polypeptide OTTMUSP00000044881 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010489 matrilysin
References
(Earliest) J:26885 Wilson CL, et al., The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell. 1995 Jul;6(7):851-69
(Latest) J:221278 Krakowiak MS, et al., Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene. 2015 Apr 2;34(14):1865-71
All references(103)
Other
accession IDs
MGD-MRK-24057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory