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Mmp7
Gene Detail
 Symbol
Name
ID
Mmp7
matrix metallopeptidase 7
MGI:103189
Synonyms MAT, matrilysin
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:7692090-7699585 bp, + strand
From VEGA annotation of GRCm38

  7496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: matrilysin-like proteinase
Gene Tree: Mmp7

Human
homologs
Human Homolog MMP7, matrix metallopeptidase 7 (matrilysin, uterine)
NCBI Gene ID 4316
neXtProt AC  NX_P09237
Human Synonyms  MMP-7, MPSL1, PUMP-1
Human Chr (Location)  11q21-q22; chr11:102520508-102530747 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to induced colitis and corneal wound neovascularization, decreased sensitivity to myocardial infarction and pancreatic duct ligation, impaired tracheal wound healing, and altered tumor susceptibility.
 
Interactions
Mmp7 interacts with 46 markers (Mir1b, Mir15b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process antibacterial peptide secretion, collagen catabolic process, ...
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (66)    Tissues (55)    Images (5)
Theiler Stages: 17, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RT-PCR 66
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(7) cDNA(16) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033289 (Evidence)
Ensembl Gene ModelENSMUSG00000018623 (Evidence)
Entrez Gene17393 (Evidence)
UniGene4825
DFCITC1585074
DoTSDT.487628
EC3.4.24.23
Consensus CDS ProjectCCDS40531.1
International Mouse Knockout Project StatusMmp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033289 VEGA Gene Model | MGI Sequence Detail 7496 C57BL/6J ±  kb
transcript OTTMUST00000083491 VEGA | MGI Sequence Detail 1068 Not Applicable 
polypeptide OTTMUSP00000044881 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010489 matrilysin
References (Earliest) J:26885 Wilson CL, et al., The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell. 1995 Jul;6(7):851-69
(Latest) J:208739 Gharib SA, et al., Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol. 2013 Mar;48(3):390-6
All references(98)
Other
accession IDs
MGD-MRK-24057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory