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Nfib Gene Detail
Summary
  • Symbol
    Nfib
  • Name
    nuclear factor I/B
  • Synonyms
    6720429L07Rik, E030026I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103188
    NCBI Gene: 18028
Location & Maps
more
  • Sequence Map
    Chr4:82290173-82705750 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      415578 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NFIB, nuclear factor I/B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NFIB, nuclear factor I/B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTF, HMGIC/NFIB, NF1-B, NF-I/B, NFI-B, NFIB2, NFIB3, NFI-RED
  • Links
    NCBI Gene ID: 4781
    neXtProt AC: NX_O00712

  • Chr Location
    9p24.1; chr9:14081843-14398983 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 3 alleles in 7 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    80
  • Chemically induced (other)
    2
  • Gene trapped
    73
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Nfib
  • Incidental Mutations
Homozygous inactivation of this gene causes severe lung defects and neonatal death from respiratory failure. Homozygotes for a null allele show callosal agenesis and abnormalities in forebrain, basilar pons, hippocampus, and submandibular gland development, as well as lung maturation defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000395 VEGA Gene Model | MGI Sequence Detail 415578 C57BL/6J ±  kb
transcript OTTMUST00000021171 VEGA | MGI Sequence Detail 3294 Not Applicable  
polypeptide OTTMUSP00000009686 VEGA | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3024 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • InterPro Domains
    IPR000647 CTF transcription factor/nuclear factor 1
    IPR019739 CTF transcription factor/nuclear factor 1, conserved site
    IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
    IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
    IPR003619 MAD homology 1, Dwarfin-type
Molecular
Reagents
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  • All nucleic 39
    cDNA 35
    Primer pair 3
    Other 1

    Microarray probesets 15
Other
Accession IDs
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MGD-MRK-24056, MGI:1924433, MGI:2442665
References
more
  • Summaries
    All 78
    Developmental Gene Expression 37
    Gene Ontology 14
    Phenotypes 24
  • Earliest
    J:34412 Qian F, et al., Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995 Jul 1;28(1):66-73
  • Latest
    J:225435 Laclef C, et al., The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor. Hum Mol Genet. 2015 Sep 1;24(17):4997-5014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory