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Nfib Gene Detail
Summary
  • Symbol
    Nfib
  • Name
    nuclear factor I/B
  • Synonyms
    6720429L07Rik, E030026I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103188
    NCBI Gene: 18028
  • Gene Overview
    MyGene.info: NFIB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:82290173-82705750 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      415578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 38.40 cM, cytoband C4-C6
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NFIB, nuclear factor I B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NFIB, nuclear factor I B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTF, HMGIC/NFIB, NF1-B, NF-I/B, NFI-B, NFIB2, NFIB3, NFI-RED
  • Links
    NCBI Gene ID: 4781
    neXtProt AC: NX_O00712
    UniProt: O00712

  • Chr Location
    9p23-p22.3; chr9:14081843-14398983 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 3 alleles in 7 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes severe lung defects and neonatal death from respiratory failure. Homozygotes for a null allele show callosal agenesis and abnormalities in forebrain, basilar pons, hippocampus, and submandibular gland development, as well as lung maturation defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000395 VEGA Gene Model | MGI Sequence Detail 415578 C57BL/6J ±  kb
    transcript OTTMUST00000021171 VEGA | MGI Sequence Detail 3294 Not Applicable  
    polypeptide OTTMUSP00000009686 VEGA | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3005 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000647 CTF transcription factor/nuclear factor 1
      IPR019739 CTF transcription factor/nuclear factor 1, conserved site
      IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
      IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
      IPR003619 MAD homology 1, Dwarfin-type
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 37
      Primer pair 3
      Other 1

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-24056, MGI:1924433, MGI:2442665
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 44
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:34412 Qian F, et al., Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995 Jul 1;28(1):66-73
    • Latest
      J:260444 Hayashi M, et al., Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control. Neuron. 2018 Feb 21;97(4):869-884.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory