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Nfib
Gene Detail
 Symbol
Name
ID
Nfib
nuclear factor I/B
MGI:103188
Synonyms 6720429L07Rik, E030026I10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
38.40 cM, cytoband C4-C6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:82290173-82705750 bp, - strand
From VEGA annotation of GRCm38

  415578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: nuclear factor 1
Gene Tree: Nfib

Human
homologs
Human Homolog NFIB, nuclear factor I/B
NCBI Gene ID 4781
neXtProt AC  NX_O00712
Human Synonyms  CTF, HMGIC/NFIB, NF1-B, NF-I/B, NFI-B, NFIB2, NFIB3, NFI-RED
Human Chr (Location)  9p24.1; chr9:14081843-14398983 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(73) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit severe lung defects and open eyelids, and die soon after birth from respiratory failure. Heterozygotes exhibit delayed pulmonary differentiation.
 
Interactions
Nfib interacts with 588 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process anterior commissure morphogenesis, chondrocyte differentiation, ...
Component cerebellar mossy fiber, intracellular, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (325)    Tissues (282)    Images (53)
Theiler Stages: 2, 3, 4, 5, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 23
RNA in situ 284
Northern blot 8
RT-PCR 10
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(3) Other(1)
Microarray probesets(15)
Other database
links
VEGA Gene ModelOTTMUSG00000000395 (Evidence)
Ensembl Gene ModelENSMUSG00000008575 (Evidence)
Entrez Gene18028 (Evidence)
DFCITC1575443, TC1576610, TC1582954, TC1644480, TC1689469, TC1746849
DoTSDT.101205708, DT.101388941, DT.101388950, DT.60103154, DT.87072688, DT.91581211, DT.94305606, DT.94348564, DT.97409767
NIA Mouse Gene IndexU025201, U104819
Consensus CDS ProjectCCDS38790.1, CCDS51213.1
International Mouse Knockout Project StatusNfib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000395 VEGA Gene Model | MGI Sequence Detail 415578 C57BL/6J ±  kb
transcript OTTMUST00000021171 VEGA | MGI Sequence Detail 3294 Not Applicable 
polypeptide OTTMUSP00000009686 VEGA | MGI Sequence Detail 569 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(14) UniProt(11)
Polymorphisms RFLP(1) : SNPs within 2kb(3024 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011174 nuclear factor 1 B-type
References (Earliest) J:34412 Qian F, et al., Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995 Jul 1;28(1):66-73
(Latest) J:206928 Piper M, et al., NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development. J Neurosci. 2014 Feb 19;34(8):2921-30
All references(75)
Other
accession IDs
MGD-MRK-24056, MGI:1924433, MGI:2442665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory