About   Help   FAQ
Nfib
Gene Detail
Symbol

Name
ID
Nfib
nuclear factor I/B
MGI:103188
Synonyms
6720429L07Rik, E030026I10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
38.40 cM, cytoband C4-C6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:82290173-82705750 bp, - strand
From VEGA annotation of GRCm38

  415578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NFIB
Protein SuperFamily: nuclear factor 1
Gene Tree: Nfib

Human
homologs
NFIB, nuclear factor I/B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4781
neXtProt AC: NX_O00712

Human Synonyms: CTF, HMGIC/NFIB, NF1-B, NF-I/B, NFI-B, NFIB2, NFIB3, NFI-RED

Human Chr (Location): 9p24.1; chr9:14081843-14398983 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(73) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this gene causes severe lung defects and neonatal death from respiratory failure. Homozygotes for a null allele show callosal agenesis and abnormalities in forebrain, basilar pons, hippocampus, and submandibular gland development, as well as lung maturation defects.
 
Interactions
Nfib interacts with 587 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (35 records)
Data Summary: Results (323)    Tissues (279)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 282
Northern blot 8
RT-PCR 10
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfib    NEW 
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(3) Other(1)
Microarray probesets(15)
Other database
links
VEGA Gene Model OTTMUSG00000000395 (Evidence)
Ensembl Gene Model ENSMUSG00000008575 (Evidence)
Entrez Gene 18028 (Evidence)
DFCI TC1575443, TC1576610, TC1582954, TC1644480, TC1689469, TC1746849
DoTS DT.101205708, DT.101388941, DT.101388950, DT.60103154, DT.87072688, DT.91581211, DT.94305606, DT.94348564, DT.97409767
NIA Mouse Gene Index U025201, U104819
Consensus CDS Project CCDS38790.1, CCDS51213.1
International Mouse Phenotyping Consortium Status Nfib
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000395 VEGA Gene Model | MGI Sequence Detail 415578 C57BL/6J ±  kb
transcript OTTMUST00000021171 VEGA | MGI Sequence Detail 3294 Not Applicable 
polypeptide OTTMUSP00000009686 VEGA | MGI Sequence Detail 569 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(14) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(3024 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011174 nuclear factor 1 B-type
References
(Earliest) J:34412 Qian F, et al., Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995 Jul 1;28(1):66-73
(Latest) J:218202 Mellas RE, et al., NFIB Regulates Embryonic Development of Submandibular Glands. J Dent Res. 2015 Feb;94(2):312-9
All references(80)
Other
accession IDs
MGD-MRK-24056, MGI:1924433, MGI:2442665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory