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Uimc1 Gene Detail
Summary
  • Symbol
    Uimc1
  • Name
    ubiquitin interaction motif containing 1
  • Synonyms
    9430016E08Rik, D330018D10Rik, D630032M02Rik, Rxrip110
  • Feature Type
    protein coding gene
  • IDs
    MGI:103185
    NCBI Gene: 20184
  • Gene Overview
    MyGene.info: UIMC1
Location & Maps
more
  • Sequence Map
    Chr13:55027880-55100300 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72421 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 29.80 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UIMC1, ubiquitin interaction motif containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    UIMC1, ubiquitin interaction motif containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RAP80, X2HRIP110
  • Links
    NCBI Gene ID: 51720
    neXtProt AC: NX_Q96RL1

  • Chr Location
    5q35.2; chr5:176905005-177022571 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    5
  • Genomic Mutations
    2 involving Uimc1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit premature death due to B-cell lymphomas and abnormal DNA repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032667 VEGA Gene Model | MGI Sequence Detail 72421 C57BL/6J ±  kb
transcript OTTMUST00000081249 VEGA | MGI Sequence Detail 2936 Not Applicable  
polypeptide OTTMUSP00000043431 VEGA | MGI Sequence Detail 727 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    230 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029844 BRCA1-A complex subunit RAP80
  • PDB
  • InterPro Domains
    IPR003903 Ubiquitin interacting motif
Molecular
Reagents
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  • All nucleic 85
    cDNA 85

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-24053, MGI:1924548, MGI:2443168, MGI:2443285
References
more
  • Summaries
    All 34
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
  • Latest
    J:211168 Kakarougkas A, et al., Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Res. 2013 Dec;41(22):10298-311

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory