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Uimc1
Gene Detail
Symbol

Name
ID
Uimc1
ubiquitin interaction motif containing 1
MGI:103185
Synonyms
9430016E08Rik, D330018D10Rik, D630032M02Rik, Rxrip110
Feature Type
protein coding gene
Genetic Map
Chromosome 13
29.80 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:55027880-55100300 bp, - strand
From VEGA annotation of GRCm38

  72421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9455  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: UIMC1
Gene Tree: Uimc1

Human
homologs
UIMC1, ubiquitin interaction motif containing 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51720
neXtProt AC: NX_Q96RL1

Human Synonyms: RAP80, X2HRIP110

Human Chr (Location): 5q35.2; chr5:176905005-177022571 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Genomic Mutations involving Uimc1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit premature death due to B-cell lymphomas and abnormal DNA repair.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Uimc1 interacts with 239 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component BRCA1-A complex, nucleus
Function histone binding, K63-linked polyubiquitin binding, ...
External Resources: FuncBase
Expression
cDNA source data(83)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase uimc1    NEW 
Molecular
reagents
All nucleic(85) cDNA(85)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000032667 (Evidence)
Ensembl Gene Model ENSMUSG00000025878 (Evidence)
Entrez Gene 20184 (Evidence)
UniGene 259301
DFCI TC1577193, TC1592471, TC1626941
DoTS DT.101194577, DT.91282468, DT.99850512, DT.99850516
NIA Mouse Gene Index U034807
PDB 3A1Q
Consensus CDS Project CCDS36671.1
International Mouse Phenotyping Consortium Status Uimc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032667 VEGA Gene Model | MGI Sequence Detail 72421 C57BL/6J ±  kb
transcript OTTMUST00000081249 VEGA | MGI Sequence Detail 2936 Not Applicable 
polypeptide OTTMUSP00000043431 VEGA | MGI Sequence Detail 727 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(13) UniProt(4)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003903 Ubiquitin interacting motif
Protein Ontology PR:000029844 BRCA1-A complex subunit RAP80
References
(Earliest) J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
(Latest) J:211168 Kakarougkas A, et al., Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Res. 2013 Dec;41(22):10298-311
All references(37)
Other
accession IDs
MGD-MRK-24053, MGI:1924548, MGI:2443168, MGI:2443285

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory