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Slc19a1
Gene Detail
 Symbol
Name
ID
Slc19a1
solute carrier family 19 (folate transporter), member 1
MGI:103182
Synonyms reduced folate carrier, RFC1, RFC-1
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:77032241-77061002 bp, + strand
From VEGA annotation of GRCm38

  28762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: folate/thiamine transporter
Gene Tree: Slc19a1

Human
homologs
Human Homolog SLC19A1, solute carrier family 19 (folate transporter), member 1
NCBI Gene ID 6573
neXtProt AC  NX_P41440
Human Synonyms  CHMD, FOLT, IFC1, REFC, RFC1
Human Chr (Location)  21q22.3; chr21:45514715-45542471 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) Targeted(10)
Genomic Mutations involving Slc19a1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die due to abnormalities of hematopoietic organs. Mutant mice may be partially rescued with maternal folic acid supplementation, but these mice still present with hematopoietic organ defects and show impaired development of urogenital structures.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Slc19a1 interacts with 146 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process folic acid transport, methotrexate transport, ...
Component basolateral plasma membrane, brush border membrane, ...
Function folic acid binding, folic acid transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (239)    Tissues (192)    Images (25)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 190
RT-PCR 49
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) Genomic(15) cDNA(60) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033598 (Evidence)
Ensembl Gene ModelENSMUSG00000001436 (Evidence)
Entrez Gene20509 (Evidence)
UniGene265060
DFCITC1574724, TC1642137
DoTSDT.101386347, DT.101386348, DT.532203
NIA Mouse Gene IndexU011682
Consensus CDS ProjectCCDS35947.1
International Mouse Knockout Project StatusSlc19a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033598 VEGA Gene Model | MGI Sequence Detail 28762 C57BL/6J ±  kb
transcript OTTMUST00000084636 VEGA | MGI Sequence Detail 2309 Not Applicable 
polypeptide OTTMUSP00000045639 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(20) UniProt(9)
Polymorphisms SNPs within 2kb(238 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR002666 Reduced folate carrier
Protein Ontology PR:000014969 folate transporter 1
References (Earliest) J:32871 Schuetz JD, et al., Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. J Biol Chem. 1988 Jul 15;263(20):9840-7
(Latest) J:203885 Kooistra M, et al., Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos. Biol Reprod. 2013 Sep;89(3):63
All references(67)
Other
accession IDs
MGD-MRK-24050, MGI:2143577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory