Tcf19 MGI Mouse Gene Detail - MGI:103180

Symbol

Tcf19
Name

transcription factor 19
Synonyms

5730403J10Rik

Feature Type

protein coding gene
IDs

MGI:103180
NCBI Gene: 106795
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:35823631-35827721 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.69 cM
Mapping Data

2 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103180	protein coding gene	Chr17:35823627-35827730 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023641	protein coding gene	Chr17:35681179-35685273 (-)
A/J	MGP_AJ_G0023596	protein coding gene	Chr17:34583584-34587649 (-)
AKR/J	MGP_AKRJ_G0023566	protein coding gene	Chr17:34986120-34990184 (-)
BALB/cJ	MGP_BALBcJ_G0023601	protein coding gene	Chr17:34710448-34714513 (-)
C3H/HeJ	MGP_C3HHeJ_G0023367	protein coding gene	Chr17:35454440-35458504 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024043	protein coding gene	Chr17:37146093-37150183 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021521	protein coding gene	Chr17:32284669-32288703 (-)
CAST/EiJ	MGP_CASTEiJ_G0022858	protein coding gene	Chr17:35554985-35559052 (-)
CBA/J	MGP_CBAJ_G0023345	protein coding gene	Chr17:38690053-38694117 (-)
DBA/2J	MGP_DBA2J_G0023469	protein coding gene	Chr17:33898196-33902261 (-)
FVB/NJ	MGP_FVBNJ_G0023440	protein coding gene	Chr17:33688261-33692335 (-)
LP/J	MGP_LPJ_G0023549	protein coding gene	Chr17:36067458-36071552 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023461	protein coding gene	Chr17:37497246-37502161 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024086	protein coding gene	Chr17:35323750-35327842 (-)
PWK/PhJ	MGP_PWKPhJ_G0022609	protein coding gene	Chr17:32750270-32754362 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022428	protein coding gene	Chr17:33360483-33364520 (-)
WSB/EiJ	MGP_WSBEiJ_G0022924	protein coding gene	Chr17:35454880-35458944 (-)

Human Ortholog

TCF19, transcription factor 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TCF19, transcription factor 19
Synonyms

SC1, TCF-19
Links

HGNC:11629

NCBI Gene ID: 6941

neXtProt AC: NX_Q9Y242

UniProt: Q9Y242
Chr Location

6p21.33; chr6:31158331-31167159 (+) GRCh38

MGI Vertebrate Homology

Tcf19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TCF19
Gene Tree

Tcf19

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

5
Targeted

5
Genomic Mutations

1 involving Tcf19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

53
cDNA Data

13
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tcf19

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All Sequences

59
RefSeq

8
UniProt

4
CCDS

CCDS50089.1

Ensembl

ENSMUSG00000050410 (Evidence)
NCBI Gene

106795

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050410	Ensembl Gene Model \| MGI Sequence Detail	4091	C57BL/6J	± kb
transcript	ENSMUST00000161012	Ensembl \| MGI Sequence Detail	1665	Not Applicable
polypeptide	ENSMUSP00000125310	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016178 transcription factor 19

(term hierarchy)
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily

IPR042803 Transcription factor 19

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All nucleic 13

cDNA 13

Microarray probesets 4

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MGD-MRK-24048, MGI:1913880, MGI:2147068

Summaries

All 41

Developmental Gene Expression 9

Gene Ontology 2

Phenotypes 11
Earliest

J:51318 Ku DH, et al., A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Cell Growth Differ. 1991 Apr;2(4):179-86
Latest

J:270210 Loo L, et al., Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134

TSS for Tcf19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147840	Chr17:35827677-35827732 (-)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23